Compound borneol antibacterial agent

A technology of antibacterial agent and borneol, applied in the field of pharmaceutical preparations, can solve the problems such as no reports of external use of methyl salicylate, and achieve the effects of relieving wound infection, better effect, and remarkable bacteriostatic and bactericidal effects.

Active Publication Date: 2019-09-13
JIANGXI ACAD OF FORESTRY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] So far, there have been no relevant reports on topical antibacterial preparations compounded with methyl salicylate, borneol, limonene, bornyl acetate, and bornhol

Method used

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  • Compound borneol antibacterial agent
  • Compound borneol antibacterial agent
  • Compound borneol antibacterial agent

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Embodiment one formula and formulation preparation

[0019] Preparation 1 compound borneol antibacterial ointment

[0020] formula:

[0021] Main ingredients: borneol acetate 8.5g, limonene 0.4g, borneol 1g, methyl salicylate 0.1g;

[0022] Base: 90g vaseline, 10g lanolin;

[0023] Ointment formulation preparation process:

[0024] (1) Weigh the main ingredients of the formula ratio respectively, and grind the borneol in it finely;

[0025] (2) Each weighs Vaseline and lanolin, which are half the amount of the formula, and grinds the Vaseline and lanolin to obtain an ointment base;

[0026] (3) Add bornyl acetate to the ointment base in an equal and increasing manner, grind well, and then add borneol, limonene, and methyl salicylate to the ointment base in sequence, and grind well;

[0027] (4) Continue to add the remaining vaseline and lanolin to it, grind it well to get the compound borneol antibacterial ointment, seal it and store it in a cool place or refrigera...

Embodiment 2

[0044] Embodiment two in vitro antibacterial experiment

[0045] 1 Experimental strain

[0046] Staphylococcus aureus (Staphylococusaureus, ATCC6538),

[0047] Candida albicans (Candida albicans, ATCC10231),

[0048] Escherichia coli (Migula) Castellani et Chulmers, ATCC8099);

[0049] 2 Drugs and reagents

[0050] Sodium chloride (analytical grade AR), tryptone, yeast extract, agar powder, PBS buffer

[0051] Culture medium: beef extract soup liquid medium: self-made - preparation of beef extract soup liquid medium (bacteria culture medium): weigh 2.0g of beef extract, 2.0g of peptone, and 1.0g of sodium chloride, put them into a beaker, add After a small amount of distilled water is heated and melted, add distilled water to 200ml, then adjust the pH value to 7.4-7.6 with 20g / dl sodium hydroxide solution, filter with filter paper, pack it in a Erlenmeyer flask, and sterilize at 103.4kPa for 20 minutes.

[0052] Liquid Sabouraud medium (SD) (fungus medium): purchased from...

example 1

[0066] Example 1 Anti-Staphylococcus aureus experiment

[0067] There are 12 test tubes in each row, numbered 1-12, a total of 7 rows of test tubes, and the drug solution is diluted by the double dilution method of the drug solution in the test tube, that is, the broth dilution method. 10mg / ml borneol stock solution, 10mg / ml borneol acetate stock solution, 10mg / ml compound borneol antibacterial agent stock solution, 10mg / ml penicillin sodium stock solution, 10mg / ml methyl salicylate stock solution, 10mg After the stock solution of limonene / ml and the stock solution of 10mg / ml compound beclomethasone camphor cream were diluted with beef extract soup liquid medium respectively, the concentration was 1280 μg / ml, and then respectively added the above-mentioned Dilute 2ml of culture solution containing different antibacterial liquids, then, mix well in No. 2 test tube, then suck out 2ml of liquid into No. 3 test tube, mix well in No. 3 test tube, then suck out 2ml of liquid into No...

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Abstract

The invention provides a compound borneol antibacterial agent, and belongs to the technical field medicine preparations. The antibacterial agent includes, mass percentage, 85-90% of bornyl acetate, 2.5-5% of limonene, 5-10% of borneol, and 1-1.5% of methyl salicylate. The provided antibacterial agent is significant in bacteriostatic and bactericidal effects, can be used for inhibiting and killingstaphylococcus aureus, candida albicans and Escherichia coli, and has antibacterial broad spectrum and extensive applicability; and the antibacterial agent can treat infectious skin diseases caused byvarious fungi or bacteria, alleviate wound infection, has no nontoxicity and no irritation on skins and is safe and effective.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, in particular to a compound borneol antibacterial agent. Background technique [0002] Borneol, also known as borneol, includes three isomers of D-borneol, L-borneol and Isoborneol. As a representative drug of aromatherapy, borneol plays an important independent and adjuvant role. At present, there have been many research reports on the antibacterial properties of borneol at home and abroad. In the in vitro antibacterial experiments on 14 common pathogenic strains, it was found that borneol was effective against Staphylococcus aureus, drug-resistant Staphylococcus aureus and Staphylococcus albus. Obvious bacteriostatic effect, bacteriostatic effect at lower concentration, bactericidal effect at high concentration, bacteriostatic effect increases with action time, weakens with decrease of drug concentration (Unlu M, Daferera D, Donmez E, Polissiou M, Tepe B, Sokmen A. Composi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/015A61K31/22A61K31/618A61K31/045A61P17/00A61P31/10A61P31/04
CPCA61K31/015A61K31/045A61K31/22A61K31/618A61P17/00A61P31/04A61P31/10A61K2300/00Y02A50/30
Inventor 熊振宇徐旭杨海宽
Owner JIANGXI ACAD OF FORESTRY
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