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Compound indomethacin cataplasms and preparation method thereof

A technology of compound indomethacin gel plaster and ethanol extraction, which is applied in the direction of anti-inflammatory agents, pharmaceutical formulas, non-central analgesics, etc., can solve problems such as restricted use, gastrointestinal reactions, and addiction restrictions, and achieve the goal of overcoming Poor compliance, fast onset and long-lasting effects

Active Publication Date: 2019-10-08
HANGZHOU NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, opioids and non-steroidal anti-inflammatory drugs are the most commonly used analgesics. Due to the strong addiction of opioids, their clinical use is strictly limited; non-steroidal anti-inflammatory drugs are easy to cause digestion Road reaction, which largely limits its use

Method used

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  • Compound indomethacin cataplasms and preparation method thereof
  • Compound indomethacin cataplasms and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Rhubarb, Radix Paeoniae Alba, Angelica, and Pinellia were crushed through a 10-mesh sieve, and 10g of rhubarb, 8g of Radix Paeoniae Alba, 10g of Angelica sinensis, and 12g of Pinellia Pinellia were taken; 15 times the amount of 70% ethanol was added to the medicinal material powder, heated and refluxed for 3 hours, filtered, and concentrated at 78°C The liquid medicine is about 15mL, take 350mg of indomethacin dissolved in 8mL of absolute ethanol and add, mix well; take 3g of azone, 0.5g of aluminum glyoxylate, 0.5g of EDTA-2Na, 7g of sodium polyacrylate NP800, 0.1g of nigerin Add 30g of glycerin to dissolve parkin ethyl ester; take 4g of povidone, 0.1g of tartaric acid, and 0.3g of menthol and add water to make it wet; put the above solutions into a vacuum stirring pot, evacuate to -0.5MPa, and use 500-1500rpm, Stir at 40°C for 10 minutes, pour the paste into the hydrogel coating machine, apply it on the non-woven fabric, add a protective film, put it into the special-s...

Embodiment 2

[0028] Modified Franz diffusion cell. Add phosphate buffer solution into the receiving pool, take the treated isolated mouse skin and cut it into a suitable size, place the cuticle upwards in the diffusion pool, take the cut compound indomethacin gel paste (self-made), indomethacin Gel plaster (self-made) and indomethacin cataplasm (commercially available) were pasted on the surface of the isolated skin, and the diffusion cell was placed in a constant temperature water bath (temperature 37±1°C, speed 200rpm). The receiving solution was taken at 8 time points within 24 hours, and an equal amount of phosphate buffer solution heated to 37°C was added to the diffusion cell.

[0029] The receiving solution obtained at each time point was filtered through a 0.45 μm microporous membrane, and the diluted mobile phase was precisely measured and diluted for HPLC detection. according to Calculate the cumulative permeation Q per unit area at different times (μg cm -2 ), where C n The...

Embodiment 3

[0031] The analgesic effect of the compound indomethacin gel patch was observed by injecting irritating chemicals to writhe the mice: 18 ICR female mice were selected, which were respectively the blank group, the indomethacin group and the compound indomethacin group. Weigh each mouse, record their weight, and then use scissors and a razor to depilate the back of the mouse to avoid cutting the mouse, and then paste the corresponding plaster on the depilated position of the buttock and back (The blank group is pasted with gel plaster with blank matrix, the indomethacin group is pasted with commercially available indomethacin cataplasm, and the compound indomethacin group is pasted with homemade compound indomethacin gel plaster. The size of the gel plaster is all cut to a suitable size. area), continuous administration for one week, 1 hour after the last administration, intraperitoneal injection of acetic acid solution in each mouse to produce peritonitis pain, observe the time ...

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Abstract

The invention belongs to the technical field of Chinese medicine preparations, and particularly relates to compound indomethacin cataplasms and a preparation method thereof. The compound indomethacincataplasms is an indomethacin compound preparation, and is prepared from the components of indomethacin, white peony roots, angelica, pinellia, rhubarb, medicinal auxiliary materials and purified water. The preparation process mainly includes the steps of pretreatment of medical materials, extraction, filtration, concentration, cataplasms preparation, mixing, coating and film covering. The indomethacin compound preparation has the advantages of reducing the adverse reaction of a main medicine, prolonging the medical efficacy time, convenient use and exact curative effect.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine preparations, and in particular relates to a compound indomethacin gel plaster and a preparation method thereof. Background technique [0002] Pain is a common symptom in clinical diseases, such as rheumatoid arthritis pain and sports injuries. At present, opioids and non-steroidal anti-inflammatory drugs are the most commonly used analgesics. Due to the strong addiction of opioids, their clinical use is strictly limited; non-steroidal anti-inflammatory drugs are easy to cause digestion Road reaction, which largely limits its use. In order to obtain a preparation with few side effects and good analgesic effect, a compound plaster combining Chinese and Western medicine is used. [0003] Gel plaster, formerly known as cataplasm, refers to the raw material drug mixed with a suitable hydrophilic matrix (skeleton material, cross-linking agent, cross-linking regulator, tackifier, ...

Claims

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Application Information

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IPC IPC(8): A61K9/70A61K47/32A61K36/8888A61P29/00A61K31/405
CPCA61K9/7023A61K47/32A61K36/71A61K36/65A61K36/232A61K36/8888A61K36/708A61K31/405A61P29/00A61K2236/33A61K2236/51A61K2300/00Y02A50/30
Inventor 王淑玲孙云廷李欣岳扈金东门连汇
Owner HANGZHOU NORMAL UNIVERSITY
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