Hydrophilic lubricating coating for medical device and preparation method of hydrophilic lubricating coating

A technology for medical equipment and lubricating coating, applied in the field of medical equipment, can solve the problems of complex manufacturing process, side effects, vascular blockage, etc., and achieve the effects of simple and easy preparation method, good biocompatibility, and improvement of rejection reaction.

Active Publication Date: 2020-02-21
苏州凝智新材料发展有限公司
View PDF14 Cites 13 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although these hydrophilic coatings have improved the lubricity and hydrophilicity on medical devices and consumables, because the coating itself cannot form effective chemical bonds with the substrate, it is difficult to maintain the stability of the coating during long-term service. Generally, there will be problems such as shedding or failure, and the shedding coating material may cause further blockage of blood vessels, resulting in more serious side effects
And CN 104936628A uses polyvalent cationic substances to make sulfated/sulfonated substances and itself and negatively charged substances as coating materials, and it is polymerized in situ to form a hydrophilic polymer coating on the surface of a

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Hydrophilic lubricating coating for medical device and preparation method of hydrophilic lubricating coating
  • Hydrophilic lubricating coating for medical device and preparation method of hydrophilic lubricating coating
  • Hydrophilic lubricating coating for medical device and preparation method of hydrophilic lubricating coating

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0065] This embodiment provides a hydrophilic lubricating coating for the surface of a stainless steel guide wire, the preparation method of which is as follows:

[0066] (1) Clean the surface of the stainless steel guide wire with acetone, ethanol and water in sequence, and dry it for later use; soak the cleaned stainless steel guide wire in a hydrochloric acid solution with a mass concentration of 50%, and place it in an ultrasonic cleaner for 20 minutes , take it out and dry it for later use;

[0067] (2) Put the cleaned stainless steel guide wire obtained in step (1) into an oxygen plasma cleaner for surface activation treatment for 20 minutes, take it out and put it into deionized water for subsequent use;

[0068] (3) Prepare an aqueous solution of sodium methacrylate (model: Sigma-Aldrich 408212) with a mass concentration of 10%, adjust the pH to 3.5 with an aqueous hydrochloric acid solution with a molar concentration of 0.1mol / L; add 6 μL of 3- (Trimethoxysilyl) prop...

Embodiment 2

[0072] The present embodiment provides a kind of hydrophilic lubricating coating that is used for polyether block polyamide (Pebax) macromolecule guidewire surface, and its preparation method is as follows:

[0073] (1) Clean the surface of the Pebax guide wire with acetone, ethanol and water in sequence, and dry it for later use;

[0074] (2) Put the cleaned Pebax guide wire obtained in step (1) into an oxygen plasma cleaning machine for surface activation treatment for 20 minutes, take it out and put it in deionized water for subsequent use;

[0075] (3) Prepare an aqueous solution of methacrylic acid (model: Sigma-Aldrich 155721) with a mass concentration of 30%, adjust the pH to 3.5 with an aqueous sodium hydroxide solution with a molar concentration of 0.1mol / L; add 9 μL of 3 - (trimethoxysilyl) propyl methacrylate (model: Sigma-Aldrich440159) as a silane coupling agent, its final mass concentration is 0.94%, stir well and wait for its hydrolysis fully; add 2 μL The etha...

Embodiment 3

[0079] The present embodiment provides a kind of hydrophilic lubricating coating that is used for thermoplastic polyurethane elastomer (TPU) surface, and its preparation method is as follows:

[0080] (1) Clean the TPU surface successively with acetone, ethanol and water, and dry it for later use;

[0081] (2) Put the cleaned TPU obtained in step (1) into an oxygen plasma cleaning machine for surface activation treatment, the time is 20min, take it out and put it into deionized water for subsequent use;

[0082] (3) Prepare an aqueous solution of sodium acrylate (model: Sigma-Aldrich 408220) with a mass concentration of 25%, and adjust the pH to 3.5 with a hydrochloric acid solution with a molar concentration of 0.1mol / l; Oxysilyl) propyl methacrylate (model: Sigma-Aldrich 440159) is used as a silane coupling agent, and its final mass concentration is 0.94%. After stirring evenly, it is fully hydrolyzed; 0.1mol / L ethanol solution of 2-hydroxy-4'-(2-hydroxyethoxy)-2-methylprop...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
Thicknessaaaaaaaaaa
Lengthaaaaaaaaaa
Login to view more

Abstract

The invention provides a hydrophilic lubricating coating for a medical device and a preparation method of the hydrophilic lubricating coating. The preparation method comprises the following steps: (1)dissolving a monomer, a silane coupling agent and an initiator in water to form a mixed solution, and carrying out free radical polymerization reaction under ultraviolet irradiation to obtain a hydrogel precursor solution for preparing the hydrophilic lubricating coating; wherein the monomer is selected from one or a combination of at least two of acrylic acid, methacrylic acid, sodium acrylate and sodium methacrylate; (2) coating the surface of the medical device with the hydrogel precursor solution obtained in the step (1); and (3) heating and curing the medical device coated with the hydrogel precursor solution obtained in the step (2) to form the hydrophilic lubricating coating. The hydrophilic lubricating coating provided by the invention can form a firm covalent bond with the medical device, so that the surface of the medical device has super-lubricating and hydrophilic characteristics, and the characteristics are stable and long-acting; the preparation method is simple and easyto implement, the coating does not need to be prepared in situ on device, and the technological process is simplified.

Description

technical field [0001] The invention belongs to the technical field of medical equipment, and in particular relates to a hydrophilic lubricating coating for medical equipment and a preparation method thereof. Background technique [0002] Vascular disease is one of the causes of death and disability in humans today. In order to prevent blood vessel blockage, doctors use implanted and interventional medical devices, such as guide wires, catheters, and stents, to treat blocked blood vessels and blood vessel walls. Unblock and dilate. During the operation, special lubricating coating treatment is applied to the device to reduce the friction between the device and the blood vessel, which can effectively reduce the difficulty of the doctor's operation, improve the success rate of the operation, and reduce the pain of the patient. It can prevent restenosis symptoms after stent implantation, thereby promoting the efficacy of medical devices and prolonging their service life. [0...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): C09D133/02C08F220/06C08F230/08C08J7/12C08J7/056A61L31/10A61L31/14C08L75/04C08L77/00
CPCA61L31/10A61L31/14A61L31/145A61L2400/10A61L2420/02C08F220/06C08J7/123C08J2375/04C08J2377/00C09D143/04C08F230/08C08L43/04
Inventor 程思博锁志刚夏崟杨灿辉念国栋姚晰
Owner 苏州凝智新材料发展有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap