Hydrophilic lubricating coating for medical device and preparation method of hydrophilic lubricating coating

Abstract

The invention provides a hydrophilic lubricating coating for a medical device and a preparation method of the hydrophilic lubricating coating. The preparation method comprises the following steps: (1)dissolving a monomer, a silane coupling agent and an initiator in water to form a mixed solution, and carrying out free radical polymerization reaction under ultraviolet irradiation to obtain a hydrogel precursor solution for preparing the hydrophilic lubricating coating; wherein the monomer is selected from one or a combination of at least two of acrylic acid, methacrylic acid, sodium acrylate and sodium methacrylate; (2) coating the surface of the medical device with the hydrogel precursor solution obtained in the step (1); and (3) heating and curing the medical device coated with the hydrogel precursor solution obtained in the step (2) to form the hydrophilic lubricating coating. The hydrophilic lubricating coating provided by the invention can form a firm covalent bond with the medical device, so that the surface of the medical device has super-lubricating and hydrophilic characteristics, and the characteristics are stable and long-acting; the preparation method is simple and easyto implement, the coating does not need to be prepared in situ on device, and the technological process is simplified.

Description

technical field [0001] The invention belongs to the technical field of medical equipment, and in particular relates to a hydrophilic lubricating coating for medical equipment and a preparation method thereof. Background technique [0002] Vascular disease is one of the causes of death and disability in humans today. In order to prevent blood vessel blockage, doctors use implanted and interventional medical devices, such as guide wires, catheters, and stents, to treat blocked blood vessels and blood vessel walls. Unblock and dilate. During the operation, special lubricating coating treatment is applied to the device to reduce the friction between the device and the blood vessel, which can effectively reduce the difficulty of the doctor's operation, improve the success rate of the operation, and reduce the pain of the patient. It can prevent restenosis symptoms after stent implantation, thereby promoting the efficacy of medical devices and prolonging their service life. [0...

AI Technical Summary

Problems solved by technology

Although these hydrophilic coatings have improved the lubricity and hydrophilicity on medical devices and consumables, because the coating itself cannot form effective chemical bonds with the substrate, it is difficult to maintain the stability of the coating during long-term service. Generally, there will be problems such as shedding or failure, and the shedding coating material may cause further blockage of blood vessels, resulting in more serious side effects

And CN 104936628A uses polyvalent cationic substances to make sulfated / sulfonated substances and itself and negatively charged substances as coating materials, and it is polymerized in situ to form a hydrophilic polymer coating on the surface of a medical device after surface activation, although The coating can form relatively strong adhesion with the substrate, but its in-situ polymerization method requires ultraviolet light treatment under the condition of isolating oxygen, and the manufacturing process is relatively complicated and the cost is high

[0004] In general, commonly used medical devices and consumables have obvious requirements for their wettability and lubricity during in vivo application, but most of the existing hydrophilic coating materials cannot maintain lubricity for a long time. There are also certain defects in the process, which cannot meet the high-volume and fast production process, and the required cost is relatively high

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