Drug composition for preventing and treating cardiotoxicity induced by anthracycline antibiotics and application for drug composition
A technology of cardiotoxicity and anthracyclines, which is applied in the field of pharmaceutical compositions for the prevention and treatment of cardiotoxicity of anthracycline antibiotics, can solve the problems of affecting the malignant tumor activity of adriamycin, use restrictions, and high prices, and achieve prevention and cardiotoxicity, Cardiotoxicity protection, the effect of reducing cardiotoxicity
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Embodiment 1
[0030] Embodiment 1, glycyrrhizin submicroemulsion
[0031] A submicron emulsion of glycyrrhizin, comprising the following components per 100mL submicron emulsion: 0.5g of liquiritinin phospholipid complex, 5.0g of soybean oil, 0.40g of lecithin, 0.40g of poloxamer 188, 0.20g of Tween 80 , 0.024g sodium oleate, 1.0g glycerol and distilled water added to 100mL, wherein the glycyrrhizin-phospholipid complex is used as a prodrug to increase the solubility of glycyrrhizin in soybean oil, and the molar ratio of glycyrrhizin and phospholipids is 1:1.
[0032] The steps for preparing the above-mentioned liquiritinin submicron emulsion are as follows: Weigh 0.5g of liquiritinin-phospholipid complex and add it to 5.0g of soybean oil as the oil phase, and heat in a water bath at 60°C. Weigh 0.40 g of lecithin, 0.40 g of poloxamer 188, 0.20 g of Tween 80, 0.024 g of sodium oleate, and 1.0 g of glycerin in an appropriate amount of distilled water at 60° C. as the water phase. Add the wa...
Embodiment 2
[0033] Embodiment 2, glycyrrhizin submicroemulsion
[0034] A submicron emulsion of glycyrrhizin is prepared from the following oil phase and water phase.
[0035] Oil phase preparation: Dissolve liquiritigenin, egg yolk phospholipid and oleic acid in absolute ethanol, add the ethanol solution to medium chain triglyceride (MCT) and soybean oil mixed oil, and remove ethanol by rotary evaporation to obtain the oil phase.
[0036] Aqueous phase preparation: weigh glycerin and poloxamer 188, add purified water to dissolve to obtain an aqueous phase.
[0037] The obtained water phase and oil phase were heated at 60° C., the water phase was slowly added to the oil phase, and the colostrum was prepared by high-speed shearing (12000 r / min) for 3 minutes. Add water to make up to 100ml, then high-pressure homogenize the colostrum (1000bar, cycle 10 times) to obtain a submicron emulsion solution, and adjust the pH value to 4.5-5.0.
Embodiment 3
[0038] Embodiment 3, glycyrrhizin submicroemulsion
[0039]Take liquiritigenin, add the prescribed amount of propylene glycol, put it in the liquid preparation tank, stir until it is completely dissolved, add 90% of the prescribed amount of water for injection, stir evenly, and adjust the pH value to 5.0 with 0.1mol / L hydrochloric acid solution or sodium hydroxide solution , add water for injection to the full amount, the measured content is qualified, after ultrafiltration with a hollow fiber ultrafiltration membrane with a molecular weight cut-off of 10kDa, the content is tested again to be qualified, filled in ampoules under aseptic conditions, and sterilized by autoclaving at 121°C and 97kPa for 15 minutes. have to.
[0040] Liquiritigenin submicron emulsion samples were diluted with ultrapure water 1:5000, and the particle size and polydispersity index were measured by Zetasizer Nano ZS90 analyzer (Malvern Instruments Co., Worcestershire, UK).
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