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Composition for preventing and treating striae gravidarum

A composition and a technology for stretch marks, which are applied in the directions of skin care preparations, medical preparations containing active ingredients, cosmetics, etc., can solve problems such as poor safety and poor efficacy, and achieve human safety, prevention and improvement of stretch marks, and effects. obvious effect

Active Publication Date: 2020-04-10
BLOOMAGE BIOTECHNOLOGY CORP LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] Aiming at the problems of poor curative effect and poor safety of current products for preventing and treating stretch marks, the present invention provides a kind of The composition for preventing and treating stretch marks of ketone has simple ingredients, is easy to prepare, has good miscibility with other ingredients, and is safe and non-toxic

Method used

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  • Composition for preventing and treating striae gravidarum
  • Composition for preventing and treating striae gravidarum
  • Composition for preventing and treating striae gravidarum

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Example 1 Effect of Transdermal Ingredients on the Transdermal Absorption Rate of Mannocuronate Silanol

[0021] 1. Composition Solution Preparation

[0022] Weigh different components according to the formula in Table 1, stir and mix to obtain the composition, and then add water until the concentration of mannuronic ester silanol in the solution is 0.04%.

[0023] Table 1 Different dosages of mannuronic ester silanol and transdermal components

[0024] .

[0025] 2. Transdermal absorption rate

[0026] with 8% Na 2 S solution removes the hair on the back of Kunming rats, cleans the skin surface with distilled water, observes that the skin is not damaged after 24 hours, and then kills the mice by taking off the neck, removes the skin on the back of the mice, removes the subcutaneous tissue and fat, and puts the skin in normal saline Store at 4°C for later use.

[0027] Using Franz diffusion cell (diffusion area 1.0cm 2 , the volume of the receiving pool is 8.5cm...

Embodiment 2

[0044] The safety evaluation of embodiment 2 composition

[0045] 1. Teratogenic risk assessment

[0046] According to the mass ratio of 2:1:1, the mannuronate silanol, acetylglucosamine and ectoine were weighed and mixed uniformly to prepare the composition.

[0047] Select a batch of well-developed juvenile male and female mice and mate in the same cage. When there is a vaginal plug at the vaginal opening of the female rat, it is considered as day 0 of conception. Then select 24 pregnant rats and divide them into two groups: 12 rats in the blank group with normal diet; 12 rats in the test group, from the 6th day to the 19th day of pregnancy, the test group weighs the body weight of the female rats every day, and according to 0.01g / 100g For body weight doses, the composition was dissolved in 1 mL of water and administered to mice by gavage. On the 30th day of pregnancy, the female mice of the two groups were sacrificed, the uteri were taken out, and the fetuses were examin...

Embodiment 3

[0059] Example 3 Preparation of cosmetics containing the composition

[0060] 1. Lotion

[0061] According to the composition in Table 6, the mannuronate silanol, acetylglucosamine and ectoine were weighed and mixed uniformly to prepare compositions 11-15.

[0062] Table 6 Composition Formulation 1

[0063]

[0064] Get the lotion as follows:

[0065] Phase A: Caprylic / Capric Triglyceride 7%, Sweet Almond Oil 3%, Jojoba Oil 1%, C 14-22 Alcohol 1.5%, C 12-20 Alkyl Glucoside 0.5%, Glyceryl Stearate 0.5%, PEG-100 Glyceryl Stearate 0.5%;

[0066] Phase B: 5% glycerin, 3% butanediol, 0.1% methylhexylglycerin, add mannocured silanol, acetylglucosamine, ectoine, and the rest of water;

[0067] Phase C: 0.5% phenoxyethanol.

[0068] (1) Weigh caprylic / capric triglyceride 7g, sweet almond oil 3g, jojoba oil 1g, C 14-22 Alcohol 1.5g, C 12-20 Alkyl glucoside 0.5g, glyceryl stearate 0.5g, PEG-100 glyceryl stearate 0.5g, heat to 80°C, stir evenly, keep warm for 15min, obtain oil...

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Abstract

The invention provides a composition for preventing and treating striae gravidarum. The composition comprises the following raw materials: mannosyl ester silanol and transdermal components, wherein the transdermal components are acetylchitosamine and ectopin; the mass ratio of the mannosyl ester silanol to the transdermal components is (4-40): (2-51); and the mass ratio of the usage amount of theacetylchitosan amine to the usage amount of the ectoine is (3-5): (1-3). The composition is a topical composition and can be prepared into forms of water, milk, cream, essence, gel, peritoneum and thelike. The composition for preventing and treating the striae gravidarum provided by the invention has the following advantages: the transdermal absorption rate of the mannosyl ester silanol can be effectively improved by virtue of the acetylchitosamine and the ectoin; the striae gravidarum can be comprehensively prevented and improved by virtue of a synergistic effect generated by the composition; meanwhile, the composition is non-irritant to the human body, and is safe and free of toxic and side effects. The composition provided by the invention is simple in component type and easy to prepare, and can be easily mixed with components into cosmetics.

Description

technical field [0001] The invention belongs to the field of cosmetics and relates to a composition for preventing and treating stretch marks. Background technique [0002] Stretch marks are a type of stretch marks. Stretch marks are red, white or purple stripes that occur when the human body breaks skin fibers during pregnancy, fitness, and sudden weight gain. It also includes fat lines, sports cracks. In addition to the abdomen, the body parts with a large range of motion include the inner and outer thighs, knees, buttocks, lumbosacral and other parts. Under normal circumstances, the elastic fibers of the skin and the rectus abdominis maintain a certain degree of elasticity, and can freely expand and contract within a certain limit. When a woman is pregnant for more than 3 months, the enlarged uterus protrudes from the pelvic cavity and develops into the abdominal cavity, the abdomen begins to swell, and the elastic fibers of the skin and abdominal muscles begin to elon...

Claims

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Application Information

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IPC IPC(8): A61K8/60A61K8/58A61K8/49A61Q19/00
CPCA61K8/60A61K8/585A61K8/4953A61Q19/00A61K2800/592
Inventor 鲍玉王玉玲李霞陈衍玲王琳琳王梦瑶徐松堂王启明范馨仪郭文逸魏健耿凤郭学平
Owner BLOOMAGE BIOTECHNOLOGY CORP LTD
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