Thrombin-loaded microsphere-expanded sponge composite hemostatic material and preparation method and application thereof

Abstract

A thrombin-loaded microsphere-expanded sponge composite hemostatic material and a preparation method and application thereof are disclosed. According to the prepared thrombin-loaded microsphere-expanded sponge composite hemostatic material, thrombin with hemostatic activity is loaded in microspheres, and the thrombin-loaded microspheres are loaded on the sponge with good swelling rate and swellingproperty. Through synergistic exertion of advantages of three ingredients, the expanded sponge with a good swelling rate can rapidly absorb moisture in blood so as to concentrate blood coagulation factors and accelerate hemostasis; the expanded sponge can generate physical compression on damaged tissues and promote hemostasis; thrombin is loaded through the microspheres, so that thrombin can be prevented from leaking and entering blood vessels to cause vascular embolism, and thrombin activity can be retained; and thrombin loaded with hemostatic active ingredients can activate a blood coagulation path to accelerate hemostasis. In addition, the microsphere-sponge composite hemostatic material has good biocompatibility, raw material sources are abundant, and the cost is controllable. Therefore, the microsphere-sponge composite hemostatic material has good clinical application prospects.

Description

technical field [0001] The invention specifically relates to the technical field of medical devices, in particular to a composite hemostatic material loaded with thrombin microspheres-swellable sponge and its preparation method and application. Background technique [0002] Uncontrollable bleeding is one of the main causes of death in battlefield trauma, traffic accidents, and surgical operations. Traditional hemostatic materials such as gauze, bandages, and cotton balls can only stop bleeding by pure physical pressure. Capillary bleeding in wounds; new hemostatic materials such as hydrogel, microspheres, and sponges have greatly improved their ability to absorb water in blood, and can achieve hemostasis by concentrating coagulation factors or blocking wounds, compared with traditional hemostatic materials. There is a certain improvement, but for the case of a large amount of bleeding, there is still a risk that the hemostatic material will be washed away by the blood, and t...

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Problems solved by technology

This method directly contacts thrombin with a cross-linking agent, and there is a risk of thrombin inactivation resulting in a decrease in the hemostatic effect; patent 200480007509.3 immobilizes thrombin on a bioabsorbable synthetic nonwoven fabric, and the bioabsorbable synthetic nonwoven fabric Polyglycolic acid, polylactic acid, and copolymers of glycolic acid and lactic acid are all hydrophobic materials, which have the disadvantages of being difficult to adhere to the wound surface and exerting the effect of thrombin

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