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Composite micron material, skin filling agent as well as preparation methods and application of composite micron material and skin filling agent

A technology of dermal fillers and composite microspheres, applied in pharmaceutical formulations, pharmaceutical sciences, prostheses, etc., can solve the problems of short validity period, particle adhesion, poor stability of mixed gel, etc.

Pending Publication Date: 2020-06-19
CHANGCHUN SINOBIOMATERIALS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, studies have found that PLLA particles cannot exist stably for a long time in an aqueous environment, and microsphere structure collapse or particle adhesion may occur when stored for more than one month. It can be seen that the hybrid gel has disadvantages such as poor stability and short validity period.

Method used

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  • Composite micron material, skin filling agent as well as preparation methods and application of composite micron material and skin filling agent
  • Composite micron material, skin filling agent as well as preparation methods and application of composite micron material and skin filling agent
  • Composite micron material, skin filling agent as well as preparation methods and application of composite micron material and skin filling agent

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0083] 1) Preparation of polylysine-polylactic acid block copolymer microspheres

[0084] Dissolve 18 grams of polylysine-polylactic acid block copolymer in 270 milliliters of chloroform, add 3600 milliliters of mass concentration to 0.5% polyvinyl alcohol aqueous solution, and emulsify for 10 minutes at an emulsifier speed of 3000 rpm , a suspension of microspheres was obtained after removal of chloroform. The suspension was washed with water and dried to obtain 17.2 g of white microsphere powder with a yield of 95.6%. Its SEM picture see figure 1 , slightly elliptical microspheres can be seen from the figure, and the particle size of the microspheres is 2-32 μm. The contact angle of the test microsphere is 69° and the water absorption rate is 28.5%, which are listed in Table 1. Compared with the contact angle of 126° and the water absorption rate of 4.4% of the simple polylactic acid microspheres, its water absorption and water absorption rate are obviously improved .

...

Embodiment 2

[0092] Dissolve 18g of polylysine amino acid-polycaprolactone block copolymer in 360mL of dichloromethane, add 2700mL of mass concentration to 2% gelatin aqueous solution, stir rapidly at 1400 rpm for 2 hours, remove the dichloromethane to obtain Aqueous suspension of microspheres. The aqueous suspension was washed with water and dried to obtain 16.5 g of white powder with a yield of 91.7%. Its SEM picture see figure 2 , it can be seen from the figure that the microspheres with regular shape core-shell structure, the particle size is 2-52μm, the contact angle is 86° and the water absorption rate is 14.3%, which are listed in Table 1. Compared with pure polycaprolactone microsphere Compared with the contact angle of 124° and the water absorption rate of 4.6%, the water absorption and water absorption rate are significantly improved.

[0093] The preparation method of polylysine-polycaprolactone block copolymer is: with reference to the method of patent CN 102827367B, take by...

Embodiment 3

[0098] To the mass concentration of 1000mL is 1% gelatin aqueous solution, add the 100mL chloroform solution of 5g poly-benzyl glutamate and polylactic acid mixture, wherein the mol ratio of poly-lactic acid and poly-benzyl glutamate is 8:1, in Emulsify for 15 minutes at an emulsification speed of 2500 rpm, and remove the chloroform to obtain an aqueous suspension of microspheres. The aqueous suspension was washed with water and dried to obtain 4.75 g of white powder with a yield of 95%. Its SEM picture see image 3 , It can be seen from the figure that the composite microspheres of polybenzyl glutamate and polylactic acid with a core-shell structure have a particle size of 5-45 μm. Its contact angle of 82° and water absorption rate of 15.2% are tested, which are listed in Table 1. Compared with the contact angle of 126° and water absorption rate of 4.4% of pure polylactic acid microspheres, its water absorption and water absorption rate are significantly improved.

[0099] ...

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Abstract

The invention discloses a composite micro material, a skin filling agent as well as preparation methods and application of the composite micron material and the skin filling agent. The composite micron material comprises the preparation raw materials selected from at least one of a polyamino acid ester and aliphatic polyester blend, a polyamino acid-aliphatic polyester block copolymer and a polyamino acid-aliphatic polyester graft copolymer. The composite microsphere can be used for preparing the filling agent for treating and improving skin winkles, sag and scars, wherein the skin filling agent comprises the following raw materials: the composite micron material and medicinal auxiliary materials in a mass ratio being (0.01-2): (0.05-0.9). The skin filling agent of the composite microspheres or particles can effectively play a role in repairing wrinkles and sag and has good application prospects.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and in particular relates to a composite micron material, a dermal filler and a preparation method and application thereof. Background technique [0002] Polyester materials, such as polylactic acid and polycaprolactone, have good biocompatibility, anticoagulation, non-toxicity and low immunity, so they are widely used in the fields of biomedicine and tissue engineering. Research in the past 30 years has shown that polyester materials and their monomers have good tissue compatibility, polyester materials can be hydrolytically degraded in physiological environments, and low molecular weight fragments can be swallowed by macrophages and degraded in cells . Among them, polylactic acid and polycaprolactone are used as raw materials for dermal fillers, and many products containing polylactic acid and / or polycaprolactone have been used for filling of skin wrinkles and depressions. Its main forms a...

Claims

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Application Information

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IPC IPC(8): A61L27/18A61L27/50
CPCA61L27/18A61L27/50A61L2400/06C08L67/04C08L77/12C08L87/005
Inventor 王晓梅崔立国石旭东崔毅庄秀丽
Owner CHANGCHUN SINOBIOMATERIALS
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