Preparation method of cyanuric acid-carbon dot composite nano phosphorescent probe and application thereof

A technology of cyanuric acid and carbon dots, applied in fluorescence/phosphorescence, chemical instruments and methods, luminescent materials, etc., can solve problems such as interference detection, and achieve the effects of mild reaction conditions, good selectivity, and easy availability of raw materials

Active Publication Date: 2020-07-10
SOUTHWEST UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, existing fluorescent sensing platforms have many drawbacks, background fluorescence and scattered light can interfere with detection

Method used

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  • Preparation method of cyanuric acid-carbon dot composite nano phosphorescent probe and application thereof
  • Preparation method of cyanuric acid-carbon dot composite nano phosphorescent probe and application thereof
  • Preparation method of cyanuric acid-carbon dot composite nano phosphorescent probe and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0064] Such as figure 1 Shown, the preparation method of cyanuric acid-carbon dot composite nano-phosphorescence probe comprises the following steps:

[0065] S1. Dissolving 3 g of manganese chloride tetrahydrate in 50 mL of water to obtain a solution of manganese chloride tetrahydrate; adding 43 mL of tetramethylammonium hydroxide and 20 mL of hydrogen peroxide to 137 mL of water to obtain a mixed solution;

[0066] S2. Mix the manganese chloride tetrahydrate solution and the mixed solution, then stir and react at 25°C for 12h, centrifuge after the end, wash the precipitate with water and methanol for 3 times, and dry it in an oven at 50°C for 1h. Obtain manganese dioxide nanosheets;

[0067] S3. Disperse the manganese dioxide nanosheets in water, and ultrasonicate for 30 minutes to make a manganese dioxide nanosheet solution with a concentration of 7 mM; dissolve the water room temperature phosphorescent material in water to make a room temperature phosphorescent material s...

Embodiment 2

[0070] In this example, in addition to replacing the concentration of the manganese dioxide nanosheet solution made in S3 of Example 1 with 400 μM, 600 μM, 1 mM, 2 mM, 3 mM, 4 mM, 5 mM, 6 mM, 8 mM or 9 mM, and adding MES buffer solution The pH value is replaced as except 5, and all the other are identical with embodiment 1.

Embodiment 3

[0072] In this example, except that the pH value of the MES buffer solution in S4 of Example 1 is replaced by 5, and the volume ratio of the manganese dioxide nanosheet solution, the room temperature phosphorescent material suspension and the MES buffer solution is replaced by 2:5:3.4 Except, all the other are identical with embodiment 1.

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Abstract

The invention discloses a preparation method of a cyanuric acid-carbon dot composite nano phosphorescent probe and an application thereof, which belongs to the field of biomaterials. The preparation method comprises the following steps: mixing a manganese chloride tetrahydrate solution with an aqueous solution of tetramethylammonium hydroxide and hydrogen peroxide, carrying out a stirring reaction, centrifuging, washing the precipitate, and drying to obtain manganese dioxide nanosheets; and mixing the ultrasonically treated manganese dioxide nano solution with a room-temperature phosphorescentmaterial suspension, adding a buffer solution, and incubating to obtain the cyanuric acid-carbon dot composite nano phosphorescent probe. The preparation method of the cyanuric acid-carbon dot composite nano phosphorescent probe has the advantages of easily available raw materials, simple process operation, mild reaction conditions, safety, environmental protection and the like; the cyanuric acid-carbon dot composite nano phosphorescent probe provided by the invention has good selectivity, low toxicity, interference resistance and stability in a biomedical detection process, and has great popularization and application values as a biosensor in the biomedical field.

Description

technical field [0001] The invention belongs to the technical field of biomaterials, and in particular relates to a preparation method and application of a cyanuric acid-carbon dot composite nano-phosphorescence probe. Background technique [0002] Afterglow materials, especially room temperature phosphorescence (RTP) materials, due to their unique singlet-triplet process, high signal-to-noise ratio and large Stokes shift, have been widely used in biological imaging and optoelectronic devices in recent years. , sensing, and information security fields have received more and more attention. Afterglow materials mainly include delayed fluorescence (delayed fluorescence, DF) and phosphorescence (phosphorescence, Phos.) materials. [0003] Fluorescent carbon dots (carbon dots, CDs) have received great attention in bioimaging, sensing, therapeutic diagnosis, and biocatalysis due to their low toxicity, excellent photostability, and simple preparation process. However, most resear...

Claims

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Application Information

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IPC IPC(8): C09K11/02C09K11/65G01N21/64
CPCC09K11/025C09K11/65G01N21/6428G01N2021/6432Y02A50/30
Inventor 杨晓明苏倩甘岚澜刘洁
Owner SOUTHWEST UNIVERSITY
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