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Nano hemostatic antibacterial composite material for vascular surgery and preparation method thereof

A hemostatic antibacterial and composite material technology, which is applied in the field of hemostatic antibacterial materials for vascular surgery, can solve the problems of unclear mechanism of action, poor hemostatic effect, and single function, and achieve the goal of enriching active sites, improving adhesion, and promoting cross-linking reactions Effect

Active Publication Date: 2020-12-18
ANQING KANGMINGNA PACKAGING
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Traditional hemostatic and antibacterial materials for vascular surgery are mainly composed of gauze and antibacterial drugs, which are simple to prepare and easy to use, but have a single function, poor hemostatic effect, and poor compatibility with wounds, which have gradually become difficult to meet the requirements of practical applications. need
In recent years, in order to improve the hemostatic effect and antibacterial effect of hemostatic antibacterial materials, some progress has been made in the research of natural polymers, synthetic polymers and inorganic nano-hemostatic antibacterial materials, but the performance of a single type of hemostatic antibacterial materials still exists. How to find a more suitable method to effectively compound various hemostatic and antibacterial materials is the current research focus
However, this hemostatic antibacterial dressing only simply compounded various hemostatic and antibacterial substances, and the mechanism of action is not clear. Substances such as N-methylolacrylamide are relatively irritating, which is not conducive to the rapid repair of wounds and has poor biocompatibility

Method used

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  • Nano hemostatic antibacterial composite material for vascular surgery and preparation method thereof
  • Nano hemostatic antibacterial composite material for vascular surgery and preparation method thereof
  • Nano hemostatic antibacterial composite material for vascular surgery and preparation method thereof

Examples

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preparation example Construction

[0031] The invention provides a preparation method of a nano-hemostatic antibacterial composite material for vascular surgery, comprising the following steps:

[0032] S1, dissolving chitosan in hydrochloric acid solution, and adjusting the pH of the solution to 5.0 to 5.5 to obtain a chitosan solution; adding a predetermined amount of ethylenediamine and carbodiimide to the chitosan solution, at 35 After reacting at ~40°C for 5-7 hours, the product is sequentially subjected to dialysis and freeze-drying to obtain amino chitosan;

[0033] S2. Put the aminated chitosan solution obtained in step S1 into the hydrochloric acid solution, and adjust the pH of the solution to 5.0-5.5 to obtain the aminated chitosan solution; dissolve 3,4,5-trihydroxybenzoic acid in ethanol Obtain 3,4,5-trihydroxybenzoic acid solution; then add the 3,4,5-trihydroxybenzoic acid solution into the aminated chitosan solution to obtain a mixed solution, and add it to the mixed solution Adding a predetermi...

Embodiment 1

[0048] This embodiment provides a preparation method of a nano-hemostatic antibacterial composite material for vascular surgery, including the following steps:

[0049] S1. Dissolve 2g of chitosan in 100mL of hydrochloric acid solution with a concentration of 0.1mol / L, and adjust the pH to 5.0, then add ethylenediamine and carbodiimide in turn, and stir the reaction at 37°C for 6h with a magnetic stirrer Finally, put the reaction product into a dialysis bag with a molecular weight cut-off of 3500, and dialyze it in acidic deionized water with pH=5 for 48 hours to remove unreacted ethylenediamine and carbodiimide; then place it at -60°C Freeze-drying for 48h to obtain amino chitosan;

[0050] Wherein, the ratio of ethylenediamine to the amount of carboxyl on the chitosan carbon chain is 25:1; the ratio of carbodiimide to the amount of carboxyl on the chitosan carbon chain is 2:1.

[0051] S2. Continue dissolving the aminated chitosan obtained in step S1 in 100 mL of hydrochlor...

Embodiment 2～5

[0063] Embodiment 2~5 and comparative example 1~2

[0064] Examples 2-5 and Comparative Examples 1-2 respectively provide a preparation method of a nano-hemostatic antibacterial composite material for vascular surgery. Compared with Example 1, the difference is that the ethylenediamine and chitosan in step S1 are changed. The ratio of the amount of carboxyl on the sugar carbon chain or the ratio of the amount of carboxyl in 3,4,5-trihydroxybenzoic acid to the amount of amino in aminated chitosan in step S2, other steps are consistent with Example 1 , which will not be repeated here. Table 2 shows the proportions of specific substances corresponding to steps S1-S2 in each embodiment and comparative example.

[0065] Table 2 The ratio of the amount of substance corresponding to steps S1 to S2 of Examples 2 to 5 and Comparative Examples 1 to 2

[0066]

[0067]

[0068] Wherein, ethylenediamine was not added in Comparative Example 1, and the ratio of the amount of carboxyl ...

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Abstract

The invention discloses a nanometer hemostatic and antibacterial composite material for the vascular surgery department and a preparation method thereof. Chitosan is sequentially subjected to amination and pyrogallol grafting treatment, and then is subjected to blended spinning with polyoxyethylene, and a nanofiber thin film is obtained; and then the nanofiber thin film is soaked into a post-treatment solution containing oxidized cellulose and nanometer zinc oxide, and then the nanometer hemostatic and antibacterial composite material is prepared. Through the above matter, the number of aminogroups on carbon chains of the chitosan can be effectively improved, and the adhesion effect of the chitosan to tissue is improved, so that the prepared nanofiber thin film has abundant active sites and excellent biocompatibility; the oxidized cellulose and the nanofiber thin film can also be cross-linked to form a three-dimensional structure, and the nanometer zinc oxide is uniformly wrapped in the three-dimensional structure, the hemostatic performance and the antibacterial performance of the nanometer hemostatic and antibacterial composite material are further improved, meanwhile, the mechanical performance of the material is improved, and high application value is achieved.

Description

technical field [0001] The invention relates to the technical field of hemostatic and antibacterial materials for vascular surgery, in particular to a nano-hemostatic and antibacterial composite material for vascular surgery and a preparation method thereof. Background technique [0002] Vascular surgery is a branch of surgery, mainly aimed at the prevention, diagnosis and treatment of peripheral vascular diseases other than cerebrovascular and cardiovascular diseases. The treatment methods mainly include drug therapy, physical therapy, surgical treatment and interventional therapy. During the treatment of vascular surgery, it is usually necessary to use hemostatic antibacterial materials to stop bleeding and protect the patient's wound, so as to promote the repair of the wound and ensure the health of the patient. Because the hemostatic and antibacterial properties of the hemostatic and antibacterial materials used will directly affect the recovery of patients' wounds, and ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): D06M15/05D06M11/44D06M13/432D01F8/18D01F8/16D04H1/728D04H3/02D01D5/00A61L15/42A61L15/46A61L15/18A61L15/28A61L15/26D06M101/02
CPCA61L15/18A61L15/26A61L15/28A61L15/42A61L15/425A61L15/46A61L2300/102A61L2300/404A61L2300/418A61L2400/04D01D5/003D01F8/16D01F8/18D04H1/728D04H3/02D06M11/44D06M13/432D06M15/05D06M16/00D06M2101/02C08L5/08C08L1/04C08L71/02
Inventor 刘成刚
Owner ANQING KANGMINGNA PACKAGING
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