Veterinary enrofloxacin flavor tablet and preparation method thereof

A technology of enrofloxacin and tablets, which is applied in the field of veterinary enrofloxacin flavored tablets and its preparation, can solve the problems of unsuitability for large-scale production of veterinary drugs, economic losses in pig breeding industry, high process costs, etc.

Active Publication Date: 2020-08-14
HUAZHONG AGRI UNIV
View PDF11 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although there are many reports about enrofloxacin taste-masking formulations, their practicability is not very satisfactory
For example, the preparation of odorless enrofloxacin in the invention patent publication number CN 103239422 requires freeze-drying, which is expensive and not suitable for large-scale production of veterinary drugs
Invention Patent Publication No. CN107412189A mentions that cyclodextrin inclusion technology and coating technology are used...

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Veterinary enrofloxacin flavor tablet and preparation method thereof
  • Veterinary enrofloxacin flavor tablet and preparation method thereof
  • Veterinary enrofloxacin flavor tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0132] The screening of solid dispersion carrier material in the enrofloxacin flavor tablet of embodiment 1 veterinary

[0133] Weigh 2.4g of the solid dispersion material as described in Table 1 and melt at 100°C, then add a small amount of enrofloxacin powder of known mass several times under continuous stirring, and stir for 30 minutes after adding until the carrier material solution Can no longer dissolve more enrofloxacin (and reach saturation), write down the mass of enrofloxacin added at this time, and calculate the maximum solubility of enrofloxacin in the solid dispersion material. See Table 1 for the maximum solubility of enrofloxacin in selected solid dispersion carrier materials (100°C, 30min). In order to ensure the stability of the prepared enrofloxacin flavor tablet and the high drug content of the product, cetyl palmitate was selected as the solid dispersion material in the formula.

[0134] Solubility of table 1 enrofloxacin in carrier material

[0135]

Embodiment 2

[0136] Example 2 Enrofloxacin flavored tablets for veterinary use are used for preparation process optimization of tablet granules

[0137] A kind of prescription (see Table 2) that is used for tableting granule in the veterinary enrofloxacin flavor tablet of the present invention.

[0138] Table 2 Recipe of Tablet Granules

[0139]

[0140]

[0141] Prepare as follows:

[0142] 1) 40 g of cetyl palmitate was heated and dissolved, then 7 g of enrofloxacin was added, and stirred to dissolve enrofloxacin in the molten cetyl palmitate to obtain solution 1;

[0143] 2) Pour solution 1 onto a cold stainless steel plate, cool and solidify for 30 minutes to obtain a solid dispersion of enrofloxacin, and pulverize the resulting solid dispersion with a pulverizer to obtain a solid dispersion of enrofloxacin with a particle size of 200 μm-800 μm body powder;

[0144] 3) After weighing 30 g of microcrystalline cellulose and 20 g of malic acid and mixing them evenly with the powd...

Embodiment 3

[0147] Example 3 Screening of prescription 1 of enrofloxacin flavor tablet for veterinary use

[0148] The design of prescription 1 of the veterinary enrofloxacin flavor tablet of the present invention is shown in Table 3.

[0149] Table 3 Composition 1 of enrofloxacin flavor tablet for veterinary use

[0150]

[0151] Prepare as follows:

[0152] 1) Heat and dissolve 40 g of cetyl palmitate, add 5 g of enrofloxacin, and stir to completely dissolve enrofloxacin in the molten cetyl palmitate to obtain solution 1.

[0153] 2) Pour solution 1 onto a cold stainless steel plate, cool and solidify for 30 minutes to obtain a solid dispersion of enrofloxacin, and pulverize the resulting solid dispersion with a pulverizer to obtain a solid dispersion of enrofloxacin with a particle size of 200 μm-600 μm body powder.

[0154] 3) After weighing 30g of microcrystalline cellulose and 21.5g of sucrose and mixing them evenly with the powder in step 2), add the 10% (3g→30mL) polyvinylpy...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
Particle sizeaaaaaaaaaa
Particle sizeaaaaaaaaaa
Login to view more

Abstract

The invention belongs to the field of veterinary drug preparation, and relates to a veterinary enrofloxacin flavor tablet and a preparation method thereof. The veterinary enrofloxacin flavor tablet isproduced by combining a solid dispersion and a wet granulation tabletting technology. The veterinary enrofloxacin flavor tablet comprises the following components in percentage by weight: 2.5-15.0% of enrofloxacin, 5.0-60.0% of a solid dispersion material, 1.0-5.0% of an adhesive, 20.0-35.0% of a diluent, 10.0-30.0% of a flavoring agent and 0.2-2.0% of a lubricant. The solid dispersion is used for masking the taste, so that the drug solubility and the defects of wet granulation tabletting can be improved, the defects that the enrofloxacin is small in solubility in a neutral environment of theintestinal tract and the tablet is slow to dissolve out are overcome, the palatability of pigs to the enrofloxacin is effectively improved, and the phenomenon of food refusal caused by the bitter taste of the enrofloxacin is avoided. Compared with a premix and a granule, the administration is more accurate. The tablet disclosed by the invention can be used for preventing and treating digestive tract diseases such as pet bacterial enteritis, mycoplasma pneumonia, swine salmonellosis and proliferative enteritis.

Description

technical field [0001] The invention belongs to the technical field of preparation of veterinary drug preparations, and in particular relates to a veterinary enrofloxacin flavor tablet and a preparation method thereof. Background technique [0002] Enrofloxacin, as a new fluoroquinolone drug for animals, is widely used in veterinary clinics for Klebsiella, Treatment of infections caused by Escherichia coli, Haemophilus parasuis, Salmonella, Mycoplasma, Chlamydia, Pasteurella multocida, Pasteurella hemolyticus, Staphylococcus aureus and other bacteria. Currently, enrofloxacin dosage forms on the domestic market include enrofloxacin soluble powder, enrofloxacin powder, enrofloxacin suspension, enrofloxacin tablets, and enrofloxacin injection. Among them, enrofloxacin soluble powder and enrofloxacin suspension are only for livestock and poultry, enrofloxacin powder is only for aquatic products, and enrofloxacin tablets are for pets and poultry. Because enrofloxacin has a very...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61K9/20A61K47/14A61K47/38A61K47/26A61K47/32A61K31/496A61P31/04A61P1/00
CPCA61K9/2013A61K9/2018A61K9/2027A61K9/2054A61K9/2095A61K31/496A61P1/00A61P31/04
Inventor 黄玲利谢书宇周凯翔米坤潘源虎瞿玮刘振利谢长清
Owner HUAZHONG AGRI UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products