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Artificial micro-nano robot and preparation method thereof

A nano-robot and artificial micro-technology, applied in the direction of biochemical equipment and methods, nanotechnology, nanotechnology, etc., can solve problems such as not given, and achieve strong repeatability, simple preparation process, and good biocompatibility Effect

Pending Publication Date: 2020-08-25
LULIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Although the above-mentioned patents all disclose artificial nano-robots and use them to carry drugs, how to effectively use substances in organisms, such as glucose, urea, etc. as a power source, especially to make the power controllable, and without Other marker substances can achieve the targeted movement of nanorobots only through the utilization rate of the power source. The above-mentioned patents do not give relevant reports

Method used

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  • Artificial micro-nano robot and preparation method thereof
  • Artificial micro-nano robot and preparation method thereof
  • Artificial micro-nano robot and preparation method thereof

Examples

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Embodiment 1

[0039] This embodiment provides an artificial micro-nano robot, which includes an asymmetric dimer structure composed of magnetic microspheres and gold nanoparticles, and an active enzyme located on the surface of the gold nanoparticles in the asymmetric dimer structure, wherein the The magnetic microspheres are silicon dioxide particles containing ferric oxide inside, and the particle size of the magnetic microspheres is 200nm-5μm, and the active enzymes include glucose oxidase, catalase or urease one or more of .

[0040] Among them, active enzymes are used to modify artificial micro-nano robots, so that artificial micro-nano robots can use biological media such as glucose and urea in the human body as fuel to drive their own movement, and have good biocompatibility. At the same time, by applying an external magnetic field, the movement direction of artificial micro-nano robots can be controlled artificially, which has broad application prospects in biomedical fields such as...

Embodiment 2

[0042] See figure 1 and figure 2 ,

[0043] figure 1 It is a schematic diagram of the preparation steps 3 and 4 of the artificial micro-nano robot in this embodiment;

[0044] figure 2 It is a transmission electron micrograph of the magnetic nanoparticles prepared in the 2nd step of the embodiment of the present invention;

[0045] image 3 It is a scanning electron micrograph of the artificial micro-nano robot prepared in Example 2 of the present invention.

[0046] This example uses magnetic microspheres, gold nanoparticles, and active enzymes as materials, and uses vacuum plasma sputtering technology and chemical modification technology to integrate magnetic microspheres, gold nanoparticles, and active enzymes to prepare an asymmetric Artificial micro-nano robot with dimer structure. Specifically include the following steps:

[0047] Step 1, preparing the magnetic micro-nano particles:

[0048] a. Add 1.0-10g of FeCl 3 ·6H 2 Dissolve O and 3.0-30g of sodium ace...

Embodiment 3

[0058] The difference between this implementation and Example 2 is that the targeting method of the artificial micro-nano robot is specific targeting guided by an external magnetic field.

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Abstract

The invention discloses an artificial micro-nano robot and a preparation method thereof, and relates to the field of micro-nano robots. By taking active enzymes such as magnetic micro-nano particles,silicon dioxide microspheres, nano-gold particles, glucose oxidase, catalase and urease as materials, the artificial micro-nano robot with an asymmetric dimer structure is prepared by fusing the enzymes with the catalytic activity, the magnetic micro-nano particles, the silicon dioxide microspheres and the nano-gold particles together by utilizing a vacuum plasma sputtering technology and a chemical modification method. The method is high in repeatability and simple in preparation process. The prepared artificial micro-nano robot can rapidly move by decomposing biological media such as glucosein blood and urea in the bladder without generating any substance having toxic and side effects on the body, or by applying an exogenous magnetic field, targeted movement of the artificial micro-nanorobot in the movement direction is achieved, and the artificial micro-nano robot is applied to the biomedical fields of drug targeting delivery, tumor treatment and the like.

Description

technical field [0001] The invention relates to the field of micro-nano robots, in particular to an artificial micro-nano robot and a preparation method thereof. Background technique [0002] Micro-nano robots refer to micro-nano devices that can convert energy in the environment into mechanical motion. Due to their active movement ability and good carrying capacity, micro-nano robots have broad application prospects in the fields of targeted drug delivery, microsurgery, biosensing, environmental restoration, and micro-nano manufacturing. Research hotspots in chemistry and other disciplines. After nearly two decades of unremitting efforts by scientists from various countries, the field of micro-nano robots has made great progress. At this stage, the driving methods of micro-nano robots mainly include two types: one is driven by chemical energy; the other is driven by external physical fields. Driving, such as light energy, electric energy, magnetic energy, ultrasonic energ...

Claims

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Application Information

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IPC IPC(8): C12N11/14C12N9/80C12N9/08C12N9/04C23C14/34B82Y40/00B82Y5/00
CPCC12N11/14C12N9/0006C12N9/0065C12N9/80C12Y101/03004C12Y111/01006C12Y305/01005C23C14/34C23C14/223B82Y40/00B82Y5/00
Inventor 刘猛
Owner LULIANG UNIV
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