Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Controllable degradable high-strength magnesium-based composite stent composite coating and preparation method thereof

A technology for composite stents and magnesium alloy stents, which is applied in the field of controllable degradation of high-strength magnesium-based composite stent coatings and its preparation, and can solve problems such as structural and performance stability degradation, inability to provide stable support, and failure of implanted stents , to achieve good hydrophilicity, high strength and good corrosion resistance

Active Publication Date: 2022-07-01
ZHENGZHOU UNIV
View PDF14 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Bio-magnesium alloys are ideal for vascular stent materials due to their good mechanical properties, biocompatibility and complete degradability. However, magnesium and its alloys degrade too quickly in the physiological environment of the human body, and too fast degradation will lead to implant failure. The premature failure of implanted stents leads to a sharp decline in the stability of its structure and performance, and it cannot provide stable support in the process of vascular tissue repair and reconstruction in lesion parts, which largely limits its clinical application.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Controllable degradable high-strength magnesium-based composite stent composite coating and preparation method thereof
  • Controllable degradable high-strength magnesium-based composite stent composite coating and preparation method thereof
  • Controllable degradable high-strength magnesium-based composite stent composite coating and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] The invention provides a method for preparing a controllable degradation high-strength magnesium-based composite stent composite coating, which comprises the following steps:

[0034] (1) Prefabrication of degradable magnesium alloy stent matrix: The magnesium alloy microtubes are laser-cut into vascular stents, and the vascular stents are electrochemically polished in a perchloric acid alcohol solution with a concentration of 4.25% by mass; Na 2 CO 3 , C 12 H 25 SO 4 Ultrasonic chemical degreasing was carried out in a strong alkaline mixed solution of Na and OP-10 for 3 min at a temperature of 60 °C; in 85% H 3 PO4 and NH 3 The surface oxide layer is removed in the mixed solution of HF to obtain a passivation surface with stable potential;

[0035](2) Treatment of the degradable magnesium alloy stent matrix: The degradable magnesium alloy stent matrix processed in step (1) was placed in Na 4 P 2 O 7 ·10H 2 O, ZnSO4 7H 2 O solution system, then add the corros...

Embodiment 2

[0041] The experimental conditions and operation process of steps (1) and (2) in this example are the same as those in Example 1, and the current density of single-pulse electrodeposition in step (3) is changed to 7A / dm 2 , the specific implementation steps are in the NaOH, ZnO solution system, adding KNaC 4 H 4 O 6 ·4H 2 O is used as impurity remover, pure zinc plate is used as anode, magnesium alloy substrate is used as cathode, 260 type platinum electrode is used as auxiliary electrode, protective zinc layer is prepared in single pulse mode, pulse frequency is 1000HZ, duty cycle is 10%, deposition temperature The temperature was 55°C, and the deposition time was 20 min. After the preparation was completed, it was rinsed with deionized water for 1 min, and dried with cold air at 25°C. Its AFM test such as figure 1 As shown in (a), the coating grains are fine and the roughness value Ra is 38.5nm; figure 2 As shown in (b), the wetting angle of the water contact angle tes...

Embodiment 3

[0043] The experimental conditions and operation process of steps (1) and (2) in this example are the same as those in Example 1, and the single-pulse electrodeposition in step (3) is changed to DC electrodeposition mode. The specific implementation steps are in the NaOH and ZnO solution system, Add KNaC 4 H 4 O 6 ·4H 2 O is used as impurity remover, pure zinc plate is used as anode, magnesium alloy substrate is used as cathode, 260-type platinum electrode is used as auxiliary electrode, and the protective zinc layer is prepared in DC mode. The deposition temperature is 55℃ and the current density is 3A / dm 2 , the deposition time is 20min, after the preparation is completed, rinse with deionized water for 1min to remove the residual solution on the surface, and dry it with cold air at 25°C.

[0044] After the preparation is completed according to the described steps, it can be observed by scanning electron microscope, such as Image 6 As shown in (a), the zinc layer on the...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
thicknessaaaaaaaaaa
adhesivityaaaaaaaaaa
surface roughnessaaaaaaaaaa
Login to View More

Abstract

The invention provides a controllable degradable high-strength magnesium-based composite stent composite coating and a preparation method thereof, including a degradable magnesium alloy stent matrix, and the outer layer of the degradable magnesium alloy stent matrix is ​​made of biocompatible high-strength zinc Protective coating, the average thickness of the high-strength zinc protective coating is 5 μm-40 μm, the surface roughness Ra < 40 nm, and the water contact angle < 50°. Finally, the high-strength protective zinc layer is prepared by the electrodeposition process. The zinc protective coating prepared by the method of the invention has a small structure, is uniform and dense, and is well combined with the matrix, which can significantly improve the mechanical strength and corrosion resistance of the magnesium alloy stent; The cytocompatibility and hemocompatibility of magnesium alloy vascular stents are very favorable.

Description

technical field [0001] The invention belongs to the technical field of magnesium alloy surface treatment, and in particular relates to a controllable degradation high-strength magnesium-based composite stent composite coating and a preparation method thereof. Background technique [0002] Coronary stent placement has become the most important means of interventional treatment of coronary heart disease. The new generation of biodegradable stents is favored by people because it can be degraded and absorbed by the human body, which can avoid chronic complications caused by non-degradable stents. damage, while facilitating secondary implantation. Therefore, degradable stents become an ideal substitute for permanent stents, and the research on bioabsorbable stents has broad medical application prospects. Biomagnesium alloys are an ideal choice for vascular stent materials because of their good mechanical properties, biocompatibility and complete degradability. However, magnesium...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61L31/02A61L31/08A61L31/14C25D5/42C25D7/00C25D3/22
CPCA61L31/022A61L31/088A61L31/14C25D5/42C25D7/00C25D3/22A61L2400/12
Inventor 朱世杰杨会玲石梦佳关绍康王利国奚廷斐王俊
Owner ZHENGZHOU UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com