Probiotic composition for relieving anxiety or depression and application thereof

A technology of probiotics and compositions, applied in the field of biomedicine, can solve the problems of underestimating the effect of probiotics, not in-depth research on the synergistic effect of probiotic strains and probiotic strains, and the beneficial effect of human intestinal flora is not significant, so as to improve anxiety and anxiety. Depression-like behavior, great social significance and economic value, effect of increasing numbers

Active Publication Date: 2020-10-02
WUHAN KANGFUDE BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006]However, most of the probiotic products currently on the market are only aimed at supplementing probiotics, and there is no in-depth study on the function of probiotic strains and human sub-health status and probiotics The synergistic effect between strains, or probiotics are only used as digestion aids or

Method used

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  • Probiotic composition for relieving anxiety or depression and application thereof
  • Probiotic composition for relieving anxiety or depression and application thereof
  • Probiotic composition for relieving anxiety or depression and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Example 1: Screening for the promoting effect of prebiotics on K-KLJ compound probiotics

[0032] In this example, the K-KLJ probiotic combination was screened for growth-promoting prebiotics, so as to obtain a prebiotic combination that promotes probiotics. MRS medium (beef extract 10.0g, yeast extract 5.0g, peptone 10.0g, glucose 20.0g, K 2 HPO 4 2.0g, sodium acetate 5.0g, MgSO 4 ·7H 2 O 0.2g, MnSO 4 4H 2 (00.05g, Tween 80 1.0g, triammonium citrate 2.0g, agar 15.0g, add distilled water to 1000ml) as basal medium, add candidate prebiotics or prebiotic combination to final concentration respectively to be 10%. Insert K-KLJ composite probiotic lyophilized powder (20% of plantaractobacillus lyophilized powder, 20% of Lactobacillus casei lyophilized powder, 15% of Lactobacillus reuteri lyophilized powder; Bacillus freeze-dried powder 15%, Bifidobacterium longum freeze-dried powder 5%, Bifidobacterium animalis freeze-dried powder 5%, Lactobacillus acidophilus freeze-...

Embodiment 2

[0036] Embodiment 2: solid drink for alleviating depression / anxiety

[0037] This example provides a probiotic solid beverage capable of maintaining intestinal health and improving depression / or anxiety. The composition of each auxiliary material is shown in Table 2. After the raw materials are accurately weighed, gradient mixing is carried out, and the final packaging is 10g / bag. After testing (refer to GB4789.35-2016 method description), the number of live probiotic bacteria in the solid beverage is 1.8-8.5×10 8 CFU / g.

[0038] Table 2. Solid beverages for depression / anxiety relief

[0039]

[0040]

[0041]

Embodiment 3

[0042] Example 3: Yogurt for alleviating depression / anxiety

[0043] This example provides a functional probiotic fermented yoghurt capable of maintaining intestinal health and improving depression / or anxiety. γ-Aminobutyric acid 200mg, sterilized at 95°C for 5min, then cooled to 40°C, inoculated with 0.18g of K-KLJ compound probiotic starter (20% freeze-dried powder of Streptococcus thermophilus, 15% freeze-dried powder of Lactobacillus bulgaricus, plant Lactobacillus freeze-dried powder 15%, Lactobacillus casei freeze-dried powder 25%, Bifidobacterium longum freeze-dried powder 10%, Lactobacillus acidophilus freeze-dried powder 5%, Lactobacillus helveticus freeze-dried powder 10%), after sealing Put it in a yogurt machine to ferment for 7-12 hours at 40°C, and then put it in a refrigerator at 4°C for 12 hours. After testing (refer to GB4789.35-2016 method description), the number of viable probiotic bacteria in the solid beverage is 2.7×10 8 CFU / g.

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Abstract

The invention discloses a probiotic composition for relieving anxiety or depression and an application thereof. The probiotic composition comprises prebiotics, a K-KLJ probiotic combination and functional substances. The K-KLJ probiotic composition contains at least one of lactobacillus plantarum, lactobacillus reuteri, lactobacillus casei, and lactobacillus helveticus, or also contains at least one of lactobacillus rhamnosus, lactobacillus acidophilus, bifidobacterium animalis and bifidobacterium longum. The probiotic composition of the present invention can significantly increase quantity ofbeneficial intestinal flora, improve intestinal discomfort, and reduce chronic inflammation, thereby reducing unhealthy emotion, and preventing emotional diseases such as depression and anxiety. Moreover, according to the invention, the combination of probiotic strains, the prebiotics, the probiotic strains and the functional substances have effect of significant synergistic enhancement.

Description

technical field [0001] The invention belongs to the field of biomedicine, and specifically relates to a probiotic composition for alleviating anxiety or depression by regulating intestinal flora and application thereof. Background technique [0002] The human intestine provides a good habitat for microorganisms, and the number of microorganisms in the adult intestine is as high as 10 14 , close to 10 times the number of human somatic cells; the mass reaches 1.2kg, which is close to the mass of human liver; the number of genes contained in it is about 100 times that of the human body itself, and it has metabolic functions that the human body does not have. As the largest and most complex micro-ecological system in the human body, intestinal microorganisms and their metabolites can not only regulate human health, but also play an important role as a bridge between diet and host, and are very important components of the human health system . [0003] The intestine is not only...

Claims

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Application Information

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IPC IPC(8): A23L2/38A23L2/39A23L33/135A23L33/21A23C9/13A61K35/747A61P25/22A61P25/24A61K35/745
CPCA23L2/38A23L2/39A23L33/135A23L33/21A23C9/1307A61K35/747A61K35/745A61P25/22A61P25/24A23V2002/00A23V2400/125A23V2400/147A23V2400/113A23V2400/173A23V2400/175A23V2400/515A23V2400/533A23V2400/169A23V2200/3202A23V2200/3204A23V2200/31A23V2250/5062A23V2250/284A23V2250/622A23V2250/632A23V2250/0646A23V2250/038A23V2250/1882A61K2300/00
Inventor 刘海峰刘红皮婷婷李青山
Owner WUHAN KANGFUDE BIOTECH CO LTD
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