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Hippophae rhamnoides polysaccharide, preparation method and application of hippophae rhamnoides polysaccharide in hippophae rhamnoides dry paste

A technology of seabuckthorn polysaccharides and seabuckthorn, which is applied in the direction of pharmaceutical formulations, medical preparations containing active ingredients, plant raw materials, etc., can solve the problem of drug stability and effectiveness that need to be improved, unfavorable storage and transportation of drug dosage control, and easy breeding of microorganisms and other issues, to achieve the effect of improving physiological activity and anti-fatigue effect, preventing and eliminating sports fatigue, and increasing product quality

Active Publication Date: 2020-10-02
西藏甘露藏药股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the seabuckthorn extract extracted in the prior art is troublesome to store, easy to breed microorganisms, and easy to deteriorate, which is not conducive to storage and transportation and the control of the dosage, and the stability and effectiveness of the medicine need to be improved

Method used

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  • Hippophae rhamnoides polysaccharide, preparation method and application of hippophae rhamnoides polysaccharide in hippophae rhamnoides dry paste
  • Hippophae rhamnoides polysaccharide, preparation method and application of hippophae rhamnoides polysaccharide in hippophae rhamnoides dry paste
  • Hippophae rhamnoides polysaccharide, preparation method and application of hippophae rhamnoides polysaccharide in hippophae rhamnoides dry paste

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Effect test

preparation example Construction

[0060] A preparation method of seabuckthorn polysaccharide, comprising:

[0061] Carry out degreasing process to above-mentioned seabuckthorn;

[0062] Carrying out polysaccharide extraction on the seabuckthorn after the above-mentioned degreasing treatment, and the above-mentioned extraction is extracted by ultrasonic combined with enzymatic method;

[0063] Carrying out deproteinization treatment on the extract obtained by extraction, the Sevage reagent for the above deproteinization is n-butanol and trichloroacetic acid; the above deproteinization treatment is carried out under the intervention of 3-hydroxyhexanoic acid and 1,3-dihydroxyacetone; and,

[0064] Alcohol precipitation and drying are carried out on the extract obtained in the deproteinization treatment step to obtain seabuckthorn polysaccharide;

[0065] The above seabuckthorn polysaccharide is a water-soluble polysaccharide. The preparation method uses ultrasound combined with enzyme method to extract seabuck...

Embodiment 1

[0104] A preparation method of seabuckthorn polysaccharide, comprising the following steps:

[0105] (1) Wash the seabuckthorn medicinal material, crush it to pass through a 200-mesh sieve, then add 5 times the weight of petroleum ether for stirring and degreasing, the degreasing time is 8 hours, the temperature is 55°C, and then the petroleum ether is recovered by suction filtration, and then the filter residue is washed with water 3 times, suction filtration, collecting the filter residue for later use;

[0106] (2) Add 25 times the amount of distilled water to the degreased filter residue, and use ultrasound combined with enzymatic method to extract polysaccharides. The specific operating conditions are: the enzymes used in the enzymatic method are papain, pectinase, and cellulase, and the amount of enzyme added is 2.3%, the temperature is 45°C, the pH is 6.0, the ultrasonic power is 150W, and the ultrasonic auxiliary time is 20min. After the ultrasonication is completed, t...

Embodiment 2

[0118] A kind of seabuckthorn dry paste, wherein the preparation process of extract and dry paste is as follows Figure 4 and 5 As shown, the specific preparation steps in this embodiment are as follows:

[0119] (1) After cleaning and slicing 15kg of seabuckthorn herbs, add 105L of water to a 500L sandwich pot for the first decoction. The decoction temperature is 190°C and the decoction time is 100min. Stir once every 20min. After decocting, filter through a 100-mesh sieve to obtain medicinal residue I and medicinal liquid I;

[0120] (2) Add 30L of water to the medicine dregs I, and decoct for the second time. The decoction temperature is 190°C, and the decoction time is 90 minutes. Stir once every 20 minutes. ;

[0121] (3) Add 15L of water to the medicine dregs II, and decoct for the third time. The decoction temperature is 190°C, and the decoction time is 30 minutes. Stir every 20 minutes. , discard the dregs III;

[0122] (4) Mixing medicinal liquid I, medicinal liq...

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Abstract

The invention provides a hippophae rhamnoides polysaccharide, a preparation method thereof and application of the hippophae rhamnoides polysaccharide in hippophae rhamnoides dry paste, and belongs tothe technical field of hippophae rhamnoides polysaccharide and Tibetan medicine extraction. The preparation method of hippophae rhamnoides polysaccharide comprises the following steps: degreasing hippophae rhamnoides; extracting polysaccharide from the treated hippophae rhamnoides by adopting an ultrasonic combined enzyme method; carrying out deproteinization treatment on the obtained extracting solution under the intervention of 3-hydroxyhexanoic acid and 1, 3-dihydroxyacetone; and carrying out alcohol precipitation and drying on an extracting solution obtained by deproteinization treatment to obtain the hippophae rhamnoides polysaccharide, wherein the hippophae rhamnoides polysaccharide is water-soluble polysaccharide. According to the preparation method provided by the invention, the diffusion resistance of the polysaccharide can be reduced, the extraction efficiency and the raw material utilization rate are improved, the polysaccharide loss rate is reduced, the polysaccharide yieldand the protein removal rate are improved, and the physiological activity and the anti-fatigue effect of polysaccharide are improved; the product has the effect of improving the body fatigue resistance; and the prepared hippophae rhamnoides dry paste can replace an extract to be used, and the stability and effectiveness of Tibetan medicinal materials are improved.

Description

technical field [0001] The invention belongs to the technical field of seabuckthorn polysaccharide and Tibetan medicine extraction, and in particular relates to a seabuckthorn polysaccharide, a preparation method and its application in seabuckthorn dry paste. Background technique [0002] Seabuckthorn (scientific name: Hippophae rhamnoides Linn. ), also known as Vinegar Willow and Blackthorn, is a plant of the genus Hippophaeaceae in the family Echinaceae. It is distributed in North China, Northwest, Southwest and other places in China. It is drought-resistant and wind-sand resistant. The content of vitamin C in seabuckthorn fruit is high, known as the "king of vitamin C", and seabuckthorn fruit is rich in nutrients such as polysaccharides, proteins, minerals, vitamins, fatty acids, zeaxanthin, lycopene, flavonoids and phenols. It has high nutritional value and health benefits. Ripe fruit is orange-yellow or brown-red, shrunken, with oily flesh and soft texture. The chemi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08B37/00A61K36/185A61P39/00
CPCA61K36/185A61K2236/331A61K2236/51A61P39/00C08B37/0003C08B37/006
Inventor 格桑罗布色里玛单增平措白玛旦增扎西
Owner 西藏甘露藏药股份有限公司
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