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Ionic resin-based catalyst and method for catalytically synthesizing benzoic acid by using same

A technology of ionic resin and anionic resin, which is applied in the direction of chemical instruments and methods, preparation of organic compounds, physical/chemical process catalysts, etc., can solve problems such as low recovery rate, clean and environmentally friendly, high recovery rate, and easy to cause allergies

Active Publication Date: 2020-10-20
安徽禾宸化学科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

CN2016108096529 discloses a method for producing m-dimethylaminobenzoic acid. The method adopts m-nitrobenzoic acid as a raw material and uses palladium carbon as a catalyst, but the price is expensive and the recovery is difficult, and it is not suitable for the production of aminomethylbenzoic acid. Assembly line industrial production
The existing synthetic method of p-aminomethylbenzoic acid is to use urotropine as a catalyst, by substituting benzyl with p-carboxyl group, adding ammonia water dropwise, after the reaction, excess ammonia water is steamed, and the product is obtained by cooling and suction filtration, but urotropine and other catalysts It belongs to dangerous chemical pipe products, and it is highly dangerous, flammable, easy to cause allergies, low recovery rate, and high cost
Currently on the market, there is no clean and environmentally friendly, high recovery rate, mild reaction conditions and low cost aminotoluic acid synthesis process and corresponding catalysts. Those skilled in the art urgently need to develop a kind of ionic resin-based catalyst and its catalytic synthesis of ammonia. A method for benzoic acid to meet existing usage needs and market demands

Method used

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  • Ionic resin-based catalyst and method for catalytically synthesizing benzoic acid by using same

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Effect test

Embodiment 1

[0022] The method for catalyzing the synthesis of aminobenzoic acid using an ion resin-based catalyst comprises the following steps: (1) in an enamel reactor, at a certain reaction temperature, 1 part of an ion resin-based catalyst and 5 parts of water are added to the reactor, and p-bromine is added 1 part of methyl benzoic acid, after fully stirring for 1.5 hours, add 2 parts of ammonia water dropwise at a constant speed, gradually dissolve p-bromomethyl benzoic acid during the dropping process, stir until the raw materials are completely reacted after dropping, filter out the ion resin catalyst, and pass through Recovery and application, and then the mother liquor is concentrated under reduced pressure to distill ammonia, concentrated to pH 8, cooled and filtered to obtain the crude product of p-aminomethylbenzoic acid, the yield of the crude product is 70%, the mother liquor is recovered and applied, and the yield of the mother liquor is recovered and applied 90% (2) In the...

Embodiment 2

[0027] The method for catalyzing the synthesis of aminobenzoic acid using the above-mentioned ionic resin-based catalyst comprises the following steps: (1) in an enamel reactor, at a certain reaction temperature, 0.9 parts of an ionic resin-based catalyst and 4.5 parts of water are added to the reactor, and 0.9 part of p-chloromethylbenzoic acid, after fully stirring for 1 hour, add 2 parts of ammonia water dropwise at a uniform speed, gradually dissolve the p-chloromethylbenzoic acid during the dropping process, stir until the raw materials react completely, filter out the ionic resin catalyst, And after recycling, the mother liquor was concentrated under reduced pressure to distill ammonia, concentrated to pH 8, let it cool and filtered, and obtained the crude product of p-aminomethylbenzoic acid with a yield of 63.1%. %; (2) In the refining tank, heat the obtained p-aminomethylbenzoic acid crude product to 4 times the wet weight of distilled water to 75°C, add activated carb...

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Abstract

The invention discloses an ionic resin-based catalyst and a method for catalytically synthesizing benzoic acid by using the same, and belongs to the technical field of chemical engineering. The ionicresin-based catalyst is prepared from interpenetrating polymer network microspheres composed of polychlorinated ether and polystyrene components; the catalyst is used for catalyzing and synthesizing amino-benzoic acid; compared with traditional catalysts such as urotropine, the catalyst has the advantages that the catalyst is wide in raw material source, mild in reaction, pure in product and highin yield, the catalyst is easy to recycle, the catalytic synthesis method can be used as a preferred synthesis method for synthesizing an important organic intermediate amino-benzoic acid, and the method has wide industrial application prospects and economic and practical values.

Description

technical field [0001] The invention belongs to the technical field of chemical industry, in particular to an ion resin-based catalyst and a method for catalytically synthesizing aminobenzoic acid thereof. Background technique [0002] Aminobenzoic acid, also known as p-aminomethylbenzoic acid or hemostatic aromatic acid, is mainly used as an organic synthesis intermediate, hemostatic drug, and fibrinolysis inhibitor. It is suitable for various diseases caused by the high activity of fibrinolytic enzymes. Similar to aminocaproic acid, but with better performance and wider application, it is suitable for abnormal bleeding in surgery, obstetrics and gynecology, lung disease hemoptysis, endocrine bleeding, and eczema and other diseases with strong hemorrhage, and hemostasis for common chronic bleeding The effect is particularly remarkable and has broad market application prospects. CN2016108096529 discloses a method for producing m-dimethylaminobenzoic acid. The method adopts ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J31/08C07C227/08C07C229/38C08F212/08C08F212/36C08F283/06C08F222/08
CPCB01J31/08C07C227/08C08F212/08C08F283/06B01J2231/4283C07C229/38C08F212/36C08F222/08Y02P20/584
Inventor 沈照亮夏雷
Owner 安徽禾宸化学科技有限公司
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