Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Mass spectrum ionization device

A technology of mass spectrometry and protection devices, applied in the field of ionization sources

Pending Publication Date: 2020-10-23
江苏汭博医疗科技有限公司
View PDF2 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In order to solve many problems of the existing atmospheric pressure ion source, the present invention provides an ion source device that uses soft x-rays to complete sample ionization. Through short-wave radiation in a specific wavelength range, a high-energy plasma atmosphere is formed in the surrounding space environment, and the surrounding space can be directly ionized. The air background and the sample are fully ionized, ensuring complete ionization without discrimination for complex sample components without pretreatment or matrix assistance, providing a more convenient ionization solution for mass spectrometers

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Mass spectrum ionization device
  • Mass spectrum ionization device
  • Mass spectrum ionization device

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] A mass spectrometry ionization device, its implementation is as figure 1 Shown. In the figure, 101 is a soft X-ray radiation source, which is used to generate x-rays to cover high-energy regions; 102 is a radiation source protection device, 103 is a liquid introduction interface, 104 is an excited high-energy state environment area generated by a radiation source, and 105 is a back-end mass spectrometer At the atmospheric pressure interface position, 106 is the vacuum chamber of the mass spectrometer, 107 is various ion guides, and 108 is a mass analyzer, which can be but not limited to quadrupole, ion trap, time-of-flight tube, etc. The back end of the mass spectrometer ionization device is connected to the vacuum chamber of the mass spectrometer, which specifically includes necessary structures such as various levels of ion guide, mass analyzer, and ion detector. The liquid sample enters the cavity from 103 through manual injection or peristaltic pump, and completes a ...

Embodiment 2

[0028] A mass spectrometry ionization device, its implementation is as figure 2 , 3 , 4 shown. The main part in the figure is the same as the first embodiment. The difference from the first embodiment is that in order to improve the performance of the ion source, a part of the supplementary structure is added. figure 2 Added the introduction port of 109 auxiliary sample radiation ionization assistant, used to introduce methanol, ethanol, water vapor, hydrogen sulfide, methane, helium, nitrogen and other auxiliary sample radiation ionization assistants to improve ionization efficiency or suppress background chemical noise Interference function; image 3 A 110 vacuum pump is added to extract the vacuum, and the internal pressure value is controlled at 0.1Pa~1e4Pa, which can further help suppress the background chemical noise interference and help the environment to be filled with auxiliary sample radiation ionization aids as much as possible; Figure 4 A 111 ion lens or other ion...

Embodiment 3

[0030] A mass spectrometry ionization device, its implementation is as Figure 5 Shown. In the figure, 201 is a soft X-ray radiation source, which is used to generate x-rays to cover high-energy areas; 202 is a radiation source protection device, 203 is a liquid or solid sample placement table, 204 is an excited high-energy state environment area generated by a radiation source, and 205 is a rear The position of the atmospheric pressure interface of the end mass spectrometer, 206 is the vacuum chamber of the mass spectrometer, 207 is various ion guides, and 208 is a mass analyzer, which can be but not limited to quadrupoles, ion traps, time-of-flight tubes, etc. The back end of the mass spectrometer ionization device is connected to the vacuum chamber of the mass spectrometer, which specifically includes necessary structures such as various levels of ion guide, mass analyzer, and ion detector. The back end is connected to the vacuum chamber of the mass spectrometer, which speci...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a mass spectrum ionization device. The mass spectrum ionization device consists of a radiation light source, a protective outer shell and a sample tube or table, wherein the radiation light source is arranged on the protective outer shell; short-wave radiation generated by the radiation light source faces the interior of the protective outer shell; the structural appearanceof the protective outer shell is not limited; the radiation light source and protection device integral structure, and the sample tube or table are positioned on one side of a vacuum interface; and an opening position in a protection device is in butt joint with a sampling position of a vacuum interface. According to the mass spectrum ionization device, the adopted short-wave radiation source issmall in size, simple in structure, adjustable in wave band, low in stray light and high in energy, the sample has sufficient ionization energy, the problems of desolvation and ion sampling efficiencydo not exist, the sensitivity is high, and the result reproducibility is good.

Description

Technical field [0001] The invention belongs to the technical field of ionization sources, and specifically is an ion source device that uses soft X-rays to complete ionization of samples. Background technique [0002] The ion source is the core component of the mass spectrometer. It ionizes the injected neutral substances into ions. It is the first step in the realization of mass spectrometry analysis and plays a very important role in the field of mass spectrometry technology. There are many types of ion sources, including vacuum ionization sources and atmospheric pressure ionization sources. Vacuum ionization sources such as fast atom bombardment ionization source (FAB), electron bombardment ionization source (EI), chemical ionization source (CI), etc., these ionization sources need to work under certain vacuum conditions, while atmospheric pressure ionization sources can The ion source that works in the atmosphere is the electrospray ionization source (ESI). As a relatively ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): H01J49/16H01J49/26
CPCH01J49/162H01J49/26
Inventor 丁正知徐雪峰何强
Owner 江苏汭博医疗科技有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products