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Bionic boundary lubricant and preparation method thereof

A boundary lubricant, dimethyl technology, applied in the field of biomedical materials, can solve the problems of insufficient friction performance of bionic lubricants

Active Publication Date: 2020-10-27
NANJING UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Chinese patent application CN 104870020 A discloses a method for preparing a biomimetic lubricant, using polyacrylic acid PAA as the main chain, polyethylene glycol PEG as the grafted side chain, wherein the PEG side chain is only used as a simple hydrophilic group, Imparting adequate levels of lubricity to biological tissues, resulting biomimetic lubricants have insufficient tribological properties

Method used

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  • Bionic boundary lubricant and preparation method thereof
  • Bionic boundary lubricant and preparation method thereof
  • Bionic boundary lubricant and preparation method thereof

Examples

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Effect test

Embodiment 1

[0029] (1) Wash and dry the opaque flask, and pass it into N 2 , vent the oxygen in the flask.

[0030] (2) Place the flask on a magnetic stirrer, then add AA (19ml).

[0031] (3) Wait for N 2 After purging for a few minutes, CPA-DB as chain transfer agent (CTA) was prepared as a solution and added to the flask. The specific preparation was as follows: CPA-DB (106mg, 38×10 -2 mmol) dissolved in N 2 into purged methanol (58ml).

[0032] (4)N 2 After purging for a few minutes, A-CPA as free radical initiator (I) is added in the solution prepared in step (3), and A-CPA is prepared as follows: A-CPA (26mg, 9.26×10 -2 mmol) was dissolved in 14ml methanol.

[0033] (5) After the final nitrogen purge, the flask was sealed and placed in a water bath at 60°C with magnetic stirring to initiate polymerization. After 48 hours, the flask was opened and the reaction was quenched by exposing to air and cooling in ice.

[0034] (6) The solution was diluted with 0.01M borate buffer sol...

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Abstract

The invention discloses a bionic boundary lubricant and a preparation method thereof. The preparation method comprises the following steps: taking N, N-dimethyl-N-methylacrylamidopropyl-N, N-dimethyl-N-propane sulfonic acid inner salt as a zwitterionic polyelectrolyte grafting side chain, and 4-(4, 6-dimethoxytriazine-2-yl)-4-methylmorpholine hydrochloride as an initiator, carrying out reversibleaddition - breaking chain transfer and atomic transfer radical polymerization to obtain a high-molecular polymer with the bottle brush structure. In later application, carboxylic acid groups of polyacrylic acid can be combined with amino groups on the surface of cartilage through coupling reaction of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride and N-hydroxysuccinimide to form fixedsites, so that the polyacrylic acid is anchored on the surface of the articular cartilage to play a role in boundary lubrication, frictional wear of the articular cartilage is relieved, and the cartilage repair effect is improved. The protection and treatment effects are achieved on articular cartilage injury and arthritis

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, and relates to a bionic boundary lubricant for protecting articular cartilage and a preparation method thereof. [0002] Background of the invention [0003] Osteoarthritis (OA) is a common disease that reduces the lubrication and drag-reducing ability of the joint surface. It may further lead to joint mobility impairment and eventually joint necrosis, seriously affecting the quality of life of patients. Lubricant is the main lubricating component in synovial fluid. Lubricant, as a high-molecular-weight glycoprotein, can reduce the friction coefficient in boundary mode lubrication [Swann et al. (1972) J.Biol.Chem.247:8069-73; Jay et al. (1998) J. Biomed. Mat. Res. 40:414–8; Chawla et al. (2013) Acta Biomat. 6:3388-94]. Aggrecan, the major macromolecule in cartilage, protects the degradation of the extracellular matrix during the progression of osteoarthritis. The interaction of lub...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F265/02C08F220/58C08F120/06C08F2/38A61L31/06
CPCC08F265/02C08F120/06C08F2/38A61L31/06C08F2438/01C08F2438/03
Inventor 熊党生田朔时志兵
Owner NANJING UNIV OF SCI & TECH
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