Sensor with a gold nanoparticle and quantum dot composite structure, system and method

A gold nanoparticle and composite structure technology, applied in the field of optical sensing, can solve the problems of high cost, poor signal and poor repeatability

Active Publication Date: 2020-11-03
SHANDONG UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In order to solve the problems of poor signal, poor repeatability and high cost caused by the nanostructure defects of traditional nanometal sensors, the present invention proposes a sensor with a composite structure of gold nanoparticles and quantum dots and its sensor system and method, which have high sensitivity, detection Large limit, no need to mark and no pollution, no damage to the test sample, high repetition rate, real-time rapid monitoring and many other advantages, making it used in many detection fields such as physical chemistry and biomedicine

Method used

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  • Sensor with a gold nanoparticle and quantum dot composite structure, system and method
  • Sensor with a gold nanoparticle and quantum dot composite structure, system and method
  • Sensor with a gold nanoparticle and quantum dot composite structure, system and method

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Embodiment 1

[0076] Such as figure 1 As shown, the preparation method of the refractive index sensor system of this embodiment includes the following steps:

[0077] 1) Prepare a sensor system with a composite structure of gold nanoparticles and quantum dots:

[0078] a) Select a glass sheet or a quartz sheet, a transparent substrate with a size of 10mm×10mm×1mm, such as figure 1 As shown in 101, place in isopropanol, acetone, and ultrapure water for 5 minutes for ultrasonic cleaning, blow dry with inert gas nitrogen, and place in the coating chamber of low-vacuum sputtering equipment, and determine the sputtering distance 4 -5cm, that is, the distance between the substrate and the target, cover the top cover to ensure that the entire system is well sealed, set the sputtering time to 10s, vacuumize the pressure of the coating chamber to below 2Pa, and twist the needle valve to pass argon to make the coating The vacuum degree of the chamber is maintained at 3-4Pa, the discharge current is...

Embodiment 2

[0102] In this example, necrotic cells are detected, and necrotic cells can release a biomolecule, which happens to have a specific target molecule that can bind to this biomolecule, so that the blood passes through this device, and the biomolecule binds to the specific target molecule Finally, if the detected voltage changes, it can be considered that there are necrotic cells in the blood.

[0103] The composite structure of gold nanoparticles and quantum dots obtained in Example 1 was placed in an oxygen plasma cleaning machine for 15 seconds, the functional groups of the composite structure of gold nanoparticles and quantum dots on the front side of the transparent substrate were opened, and it was soaked in biological Molecular buffer for 8 hours, the buffer containing specific biomolecules uses a mixture of NaCl with a pH value of 7 and deionized water to couple the surface of the composite structure of gold nanoparticles and quantum dots to biomolecules to form biological...

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Abstract

The invention discloses a sensor with a gold nanoparticle and quantum dot composite structure, a system and a method. Based on the local surface plasma resonance characteristics of the gold nanoparticles under total internal reflection, the microfluid technology is combined, the gold nanoparticles are directly combined with the transparent substrate, the binding force is strong, the thickness is accurate and controllable, the continuity is good, no pollution is caused, in addition, the optical property of the gold film is excellent, and the sensitivity and the accuracy are very good. Quantum dots are inserted into gaps among gold nanoparticles to obtain a gold nanoparticle quantum dot composite structure, the surface plasma resonance effect of the gold nanoparticles is enhanced, the sensoris more sensitive to changes of parameters such as the refractive index and the thickness of the composite structure and media nearby the composite structure, and research substances attached to thesurface of the structure can be detected more easily. The sensor has the advantages of high sensitivity, high stability, no marking, no damage, high accuracy, real-time rapid detection, wide application range and the like; the sensor has a great development prospect and a wide potential application value.

Description

technical field [0001] The invention relates to optical sensing technology, in particular to a sensor with a composite structure of gold nanoparticles and quantum dots, and a sensor system and method thereof. Background technique [0002] Surface plasmon resonance is an intrinsic property of gold nanoparticles, and the dielectric constant of the surrounding environment as well as the size and shape of the metal all affect its oscillation frequency. In addition, the special color, photothermal effect, and special electromagnetic field enhancement effect produced by the unique surface plasmon resonance effect of the gold nanoparticles that make up the film make it widely used in the fields of physics, chemistry, materials, biology and medicine. important applications. At present, most of the refractive index sensors are still in theoretical research, and few people have proposed real achievable practical structures, and most of the sensors are combined with optical fibers. Al...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/21G01N21/55
CPCG01N21/21G01N21/55G01N2021/216G01N2021/555
Inventor 邢飞李宗文韩雪吴田鸽姬广民田敬坤
Owner SHANDONG UNIV OF TECH
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