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Bi-component cross-linked composite material applied to urinary surgery and preparation method of bi-component cross-linked composite material

A composite material and urological technology, applied in the field of medicine, can solve the problems of wound pain stimulation, difficult to remove or replace, and inelasticity, so as to improve biocompatibility, reduce or eliminate swelling, and prevent interstitial adhesion. Even the effect

Active Publication Date: 2020-11-13
杭州仪文生物医药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the obvious defects of the high molecular polymer organic solution itself, it cannot be used for tissue wound care after urological external genital plastic surgery: (1) the formed high molecular film has a strong adhesive force and it is difficult to tear it off or remove it. Replacement; (2) The formed polymer film cannot provide a physical barrier for the wound surface due to its small thickness and inelasticity to prevent foreign matter from stimulating the tissue wound surface; (3) cannot provide a moist healing environment; (4) The polymer film The organic solution contains a large amount of organic solvent, which has a strong pain stimulating effect on the wound surface

Method used

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  • Bi-component cross-linked composite material applied to urinary surgery and preparation method of bi-component cross-linked composite material
  • Bi-component cross-linked composite material applied to urinary surgery and preparation method of bi-component cross-linked composite material
  • Bi-component cross-linked composite material applied to urinary surgery and preparation method of bi-component cross-linked composite material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0061] Obtaining of branched polylysine terminated by amino active group (first component raw material):

[0062] 1. G2-8NH 2 Branched polylysine has 8 branched chains, and each branched chain end contains an amino active group. The molecular structure is as follows figure 1 As shown, algebra: G2 (second generation), purchased from Weihai Chenyuan Molecular New Material Co., Ltd.

[0063] 2. G3-16NH 2 Branched polylysine, with 16 branched chains, each branched chain end contains an amino active group, the molecular structure is as follows figure 2 As shown, algebra: G3 (third generation), purchased from Weihai Chenyuan Molecular New Material Co., Ltd.

Embodiment 2

[0065] Preparation of branched polylysine terminated by maleimide active group (first component raw material)

[0066] 1. Preparation of G2-8EMCA branched polylysine:

[0067] Preparation of main raw materials: G2-8NH 2 Branched polylysine, succinimidyl 6-(maleimido)hexanoate (CAS No.: 55750-63-5).

[0068] Preparation principle: first, in anhydrous organic solvent, using G2-8NH 2 The amino group at the end of the branched polylysine branch is prone to nucleophilic substitution reaction with the succinimide ester of 6-(maleimido) hexanoic acid succinimide ester, and then in G2-8NH 2 Maleimide groups were introduced into branched polylysine.

[0069] Preparation Process:

[0070](1) 60 mass parts of 6-(maleimido) hexanoic acid succinimide ester is dissolved in 500 mass parts of dichloromethane to form a solution;

[0071] (2) 50 mass parts of G2-8NH 2 Branched polylysine is dissolved in 500 parts by mass of N,N-dimethylformamide / dichloromethane (volume ratio 2:3) to form ...

Embodiment 3

[0087] Preparation of branched polylysine terminated by succinimide ester active group (first component raw material)

[0088] 1. Preparation of G2-8NHS branched polylysine:

[0089] Prepare main raw material: G2-8NH of embodiment 2 2 Branched polylysine, chloroacetic acid, N-hydroxysuccinimide (CAS No.: 6066-82-6).

[0090] Preparation principle: using G2-8NH 2 -NH on branched polylysine 2 Nucleophilic substitution reaction occurs with excess chloroacetic acid to form G2-8COOH branched polylysine, and -COOH on G2-8COOH branched polylysine reacts with catalyst 1-ethyl-(3-dimethylamino Propyl) carbodiimide hydrochloride (EDC.HCl) reacts with N-hydroxysuccinimide, and then introduces succinimide ester groups on the G2-8COOH branched polylysine.

[0091] Preparation Process:

[0092] (1) 60 mass parts of G2-8NH 2 The branched polylysine is dissolved in 600 parts by mass of sodium hydroxide solution with a mass concentration of 40% to 60%, and precooled, and the precooling t...

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Abstract

The invention provides a bi-component cross-linked composite material applied to urinary surgery. The cross-linked composite material comprises a first component and a second component, wherein the first component comprises an active group-terminated branched polylysine bonded sodium carboxymethyl cellulose recombinant high-molecular compound and an active group-terminated branched polylysine bonded three-arm polyethylene glycol carboxylic acid; or an active group-terminated branched polylysine bonded sodium carboxymethyl cellulose recombinant high-molecular compound and an active group-terminated branched polylysine bonded three-arm polyethylene glycol recombinant high-molecular compound; wherein the first component is provided with a branched chain, the tail end of the branched chain contains an active group, and the second component is an active group modified polydextrose biocompatible polysaccharide cross-linking agent and an active group modified low-molecular-weight carboxymethyl cellulose biocompatible polysaccharide cross-linking agent. The bi-component cross-linked composite material applied to the urinary surgery can seal a postoperative wound surface of the urinary surgery, block external stimulation and bacteria, stop seepage, prevent adhesion and the like, and greatly promote healing.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a two-component cross-linked composite material used in urology and a preparation method thereof. Background technique [0002] In the process of external genital plastic surgery in urology (such as circumcision, vulva plastic surgery, etc.), it often involves excision or segmentation of primary tissue, separation or excision of hyperplastic tissue adhesion, electrocoagulation, and wound suture, etc., and new tissue wounds are generated during the surgical process. Clinically, this type of surgery has a high incidence of postoperative adverse reactions, including tissue adhesion, viral and bacterial infection, strong foreign body irritation, inflammation, swelling, long healing period, and unsightly healing of tissue wounds. This kind of operation is different from other surgical operations, and has high requirements on the repair effect and aesthetics of the new tis...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L26/00
CPCA61L26/008A61L26/0019A61L26/0023A61L26/0076C08L87/00
Inventor 吴建华姚江平
Owner 杭州仪文生物医药有限公司
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