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3D printing composite stent as well as preparation method and application thereof

A composite scaffold and 3D printing technology, applied in the fields of materials science and medicine, to achieve the effect of improving the quality of bone repair, excellent elasticity and toughness, and good compatibility

Pending Publication Date: 2020-11-20
EAST CHINA UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

On the other hand, in the preparation of bone repair scaffolds with complex shapes to meet the needs of personalized defect repair, the current calcium-phosphorus-based scaffolds still face challenges in various aspects such as material forming ability and dimensional accuracy control.

Method used

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  • 3D printing composite stent as well as preparation method and application thereof
  • 3D printing composite stent as well as preparation method and application thereof
  • 3D printing composite stent as well as preparation method and application thereof

Examples

Experimental program
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preparation example Construction

[0083] The preparation method of the 3D printing composite support provided by the present invention, the preparation method comprises the following steps:

[0084] (i) Provide PEGylated polyglyceryl sebacate prepolymer (PEGS prepolymer), β-tricalcium phosphate (β-TCP) nanoparticles, hexamethylene isocyanate (HDI), 2-ethylhexanoic acid Tin II and solvents;

[0085] (ii) Dissolving the PEGS prepolymer in a solvent, adding stannous 2-ethylhexanoate (Tin II), HDI and β-TCP nanoparticles in sequence and stirring evenly to obtain a bioink;

[0086] (iii) The above-mentioned bio-ink is quickly transferred into the three-dimensional printing barrel, and the three-dimensional scaffold is printed, and then transferred to a vacuum dryer for further cross-linking and curing,

[0087] Wherein, the solvent is selected from the following group: one or more of N,N-dimethylformamide, N,N-dimethylacetamide, tetrahydrofuran, dimethyl sulfoxide, and dioxane Mixed solvents.

[0088] Wherein, t...

Embodiment 1

[0106] This embodiment relates to the synthesis and purification of PEGS and the mechanism diagram of 3D printing scaffold

[0107] Synthetic route such as figure 1 As shown in A, it specifically includes the following steps:

[0108] (a) Weigh 20.23g of sebacic acid and 20.00g of PEG (the number average molecular weight is 1000g / mol) in an argon atmosphere, melt and react at 130°C for 2 hours;

[0109] (b) continue to react the product of step (a) at 130° C. under vacuum conditions for 24 hours to obtain a linear prepolymer of sebacic acid and PEG;

[0110] (c) Add 7.36 g of glycerol and 8.09 g of sebacic acid to the product of step (b), and continue the reaction at 130° C. under vacuum for 48 hours. In this reaction, the molar content of PEG relative to glycerol was 20%, and the molar ratio of hydroxyl and carboxyl groups in the total reaction was 1:1.

[0111] (d) Purify the prepolymer by ethanol dissolution-ultrapure water dialysis to remove unreacted monomers and small...

Embodiment 2

[0114] This example relates to the synthesis of β-TCP nanoparticles

[0115] Prepare β-TCP nanoparticles by wet chemical precipitation method, the specific steps are:

[0116] (a) Under continuous stirring, 0.6mol / L Ca(NO 3 ) 2 ·H 2 O solution was added dropwise to 0.4mol / L (NH 4 ) 2 HPO 4 solution;

[0117] (b) During the reaction, monitor the pH change of the solution in step (a) with a pH meter, and add a certain amount of NH 3 ·H 2 O to keep the pH range controlled at 7.1-7.5;

[0118] (c) continue stirring for 1 hour after the dropwise addition, and leave the product of step (b) at room temperature overnight;

[0119] (d) The precipitate was obtained by suction filtration using a Buchner funnel, washed three times with ultrapure water and twice with ethanol, and dried at 80° C. for 48 hours.

[0120] (e) Place the dried product of step (d) in a muffle furnace and calcinate at 800° C. for 2 hours at a heating rate of 5° C. / min to finally obtain nano-sized β-TCP p...

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Abstract

The invention discloses a 3D printing organic-inorganic composite self-forming stent and a preparation method and application thereof. According to the composite stent, the components of natural bonetissues are simulated, beta-tricalcium phosphate is used as an inorganic matrix, a high-elastomer, degradable and biocompatible polymer PEGS is used as an organic phase, HDI is used as a cross-linkingagent, stannous 2-ethylhexanoate is used as a catalyst, low-temperature self-crosslinking active biological ink is constructed, and by means of a three-dimensional printing additive technology, accurate, rapid and spontaneous forming of a defect stent with a complex shape is achieved. The rheological property, the printing property, the mechanical property, the cell behavior and the osteogenesisactivity of the bone repair stent can be regulated and optimized through the content of beta-TCP, PEGS and HDI. The precise-shape PEGS / beta-TCP stent can be highly matched with a bone defect part, thebone repair process is promoted, the bone repair quality is improved, and the 3D printing organic-inorganic composite self-forming stent is a bone repair stent having a clinical application prospect.

Description

technical field [0001] The invention relates to the fields of material science and medicine, in particular to a preparation method and application of a low-temperature self-forming PEGS / β-TCP composite scaffold based on three-dimensional printing technology. It is especially used as a scaffold material for the repair of craniofacial defects with complex structures. Background technique [0002] In recent years, the number of bone defects caused by car accidents, diseases, natural disasters, accidents and other reasons has increased year by year. Not only are there a large number of cases of bone defects in clinical practice, but it is also difficult to solve these large-area defects and complex defect repair problems. Especially for the repair of craniomaxillofacial bone tissue with complex structure is a major clinical challenge. On the one hand, artificial bone substitute materials are currently the main treatment method in addition to autologous bone and allogeneic bone ...

Claims

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Application Information

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IPC IPC(8): A61L27/12A61L27/18A61L27/50A61L27/56A61L27/58B33Y70/10B33Y80/00
CPCA61L27/18A61L27/12A61L27/50A61L27/58A61L27/56B33Y70/00B33Y80/00A61L2430/02C08L75/04
Inventor 刘昌胜袁媛张昌入王炎祥
Owner EAST CHINA UNIV OF SCI & TECH
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