Chitosan composite microsphere and chitosan composite drug-loaded microsphere, and preparation methods and application thereof
A technology of composite microspheres and drug-carrying microspheres is applied in the directions of pharmaceutical formulations, antibacterial drugs, medical preparations with inactive ingredients, etc. It can solve problems such as prolonging the release time of tetracycline hydrochloride, improve bioavailability, and facilitate industrialization. Production, reducing the effect of burst release
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Embodiment 1
[0031] The embodiment of the present application provides a kind of preparation method of chitosan composite microsphere, such as figure 1 shown, including the following steps:
[0032] S1. Dissolve chitosan powder in acetic acid solution, then add attapulgite, stir evenly, then add oil phase and formaldehyde, and continue stirring to solidify;
[0033] S2. After adding a cross-linking agent for reaction, the chitosan composite microspheres are obtained after filtration.
[0034] Concrete S1 comprises: take by weighing 1.2g chitosan powder and add to there-necked flask, pour into 25ml volume fraction and be 2% acetic acid solution, after stirring, add the attapulgite that quality is 30% of chitosan powder quality, in Stir at 40°C and 400r / min for 60min; then add liquid paraffin and Span 80 as the oil phase, stir for 60min, then add 2.5ml of formaldehyde and raise the temperature to 60°C and stir for 60min;
[0035] The specific S2 includes: adding 2ml of cross-linking agent ...
Embodiment 2
[0044] The embodiment of the present application provides a kind of preparation method of chitosan composite microsphere, such as figure 1 shown, including the following steps:
[0045] S1. Dissolve chitosan powder in acetic acid solution, then add attapulgite, stir evenly, then add oil phase and formaldehyde, and continue stirring to solidify;
[0046] S2. After adding a cross-linking agent for reaction, the chitosan composite microspheres are obtained after filtration.
[0047] Concrete S1 includes: taking by weighing 1.2g chitosan powder and adding to a three-necked flask, pouring into 25ml of acetic acid solution with a volume fraction of 2%, after stirring, adding attapulgite with a mass of 20% of chitosan powder quality, Stir for 60 minutes at 50°C with a rotation speed of 500r / min; then add liquid paraffin and Span 80 as the oil phase, stir for 90 minutes, then add 2ml of formaldehyde and raise the temperature to 60°C and stir for 60 minutes to solidify;
[0048] The ...
Embodiment 3
[0054] The embodiment of the present application provides a kind of preparation method of chitosan composite microsphere, such as figure 1 shown, including the following steps:
[0055] S1. Dissolve chitosan powder in acetic acid solution, then add attapulgite, stir evenly, then add oil phase and formaldehyde, and continue stirring to solidify;
[0056] S2. After adding a cross-linking agent for reaction, the chitosan composite microspheres are obtained after filtration.
[0057] Concrete S1 comprises: take by weighing 1.2g chitosan powder and add to there-necked flask, pour into 25ml volume fraction and be 2% acetic acid solution, after stirring, add the attapulgite that quality is 15% of chitosan powder quality, in Stir for 45min at 40°C with a rotation speed of 600r / min; then add liquid paraffin and Span 80 as the oil phase, stir for 45min, then add 2ml of formaldehyde and raise the temperature to 60°C and stir for 40min;
[0058] The specific S2 includes: adding 2ml of c...
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Abstract
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