Submucosal injection solution composition for endoscope and preparation method
A composition and solution technology, which is applied in drug delivery, medical formulation, surgery, etc., can solve the problems of poor biocompatibility, high reagent concentration, and difficulty in injection, so as to reduce postoperative bleeding, excellent effect, and easy to use. The effect of the injection
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Embodiment 1
[0037] (1) Add 1000ml of water for injection, 0.864g of sodium dihydrogen phosphate, 0.475g of disodium hydrogen phosphate, 9.0g of sodium chloride, and 0.05g of indigo in the preparation container. After the solution is completely dissolved, use the sterilized 0.45μm solution. The filter element is filtered under high pressure, and then placed in a high-pressure steam sterilizer, sterilized at 121°C for 30 minutes, to obtain phosphate buffer;
[0038] (2) After the above solution is cooled, add 2.8 g of hyaluronic acid and 3.2 g of carboxymethyl chitosan into a phosphate buffer solution in a mixing tank, seal and stir until the solution is completely dissolved;
[0039] (3) Filling is carried out under aseptic conditions to obtain submucosal injection solution composition products for endoscopes.
Embodiment 2
[0041] (1) Add 1000 ml of water for injection, 0.578 g of sodium dihydrogen phosphate, 0.215 g of disodium hydrogen phosphate, 3.2 g of sodium chloride, and 0.005 g of trypan blue to the preparation container. After the solution is completely dissolved, use the sterilized solution The 0.45μm filter element is filtered under high pressure, and then placed in a high-pressure steam sterilizer, sterilized at 121°C for 30 minutes to obtain phosphate buffer;
[0042] (2) After the above solution is cooled, add 4.0 g of hyaluronic acid and 1.8 g of carboxymethyl chitosan into a phosphate buffer solution in a mixing tank, seal and stir until the solution is completely dissolved;
[0043] (3) Filling is carried out under aseptic conditions to obtain submucosal injection solution composition products for endoscopes.
Embodiment 3
[0045] (1) Add 1000 ml of water for injection, 0.618 g of sodium dihydrogen phosphate, 0.215 g of disodium hydrogen phosphate, 7.50 g of sodium chloride, and 0.01 g of methylene blue into the preparation container. After the solution is completely dissolved, use a sterilized 0.45 μm solution. The filter element is filtered under high pressure, and then placed in a high-pressure steam sterilizer, sterilized at 121°C for 30 minutes to obtain phosphate buffer;
[0046] (2) After the above solution is cooled, add 1.3 g of hyaluronic acid and 2.7 g of carboxymethyl chitosan into a phosphate buffer solution in a mixing tank under a 100% clean environment, and seal and stir until the solution is completely dissolved;
[0047] (3) Filling is carried out under aseptic conditions to obtain submucosal injection solution composition products for endoscopes.
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