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Injection type degradable high-mineralization-activity composite bone cement and preparation method thereof

A bone cement and injection technology, which is applied in the field of medical biomaterials, can solve the problems of low mineralization activity, material loosening, implantation failure, etc., and achieve the effect of strong cell adhesion, shortened time, and improved injectability

Inactive Publication Date: 2020-12-22
CHENGDU UNIVERSITY OF TECHNOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, it has poor degradability and lack of effective osseointegration performance, so its smooth surface has poor bonding strength with surrounding bone tissue, resulting in later loosening of the material, which eventually leads to implant failure.
A Chinese patent of an injectable bioactive bone cement and its preparation method and application (application number 201310708164.5) is composed of hydroxyapatite powder, high molecular weight PMMA powder, benzoyl oxide, contrast agent and hydroquinone as the main body Composition, although injectable, but moderately degradable and low mineralizing activity
Chinese Patent A Rapidly Degradable Injectable Bone Cement and Its Application (201811113125.X) Increases biological activity by adding calcium sulfate and bioactive glass to calcium phosphate bone cement, but its biomineralization activity is not as good as that of amorphous calcium phosphate / Calcium Citrate
Chinese patent CN201811130769.X focuses on the setting time and physical properties of bone cement, ignoring the biomineralization activity of bone cement, resulting in low medical mineralization activity of bone cement

Method used

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  • Injection type degradable high-mineralization-activity composite bone cement and preparation method thereof
  • Injection type degradable high-mineralization-activity composite bone cement and preparation method thereof
  • Injection type degradable high-mineralization-activity composite bone cement and preparation method thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] After weighing 60 mesh and 10g of a powder, weigh b powder chitosan (CS) to 0g, mix and grind a composite powder and b chitosan evenly; weigh 0.86g polyvinyl alcohol (molecular weight 50000) and put Pour into 100ml of deionized water, heat at 90°C and stir until the polyvinyl alcohol is completely dissolved into liquid c, then use a pipette to absorb 3.00ml of the dissolved c solution and add it to the evenly ground a / b powder, mix and stir evenly to form a paste shape, the paste can be shaped and used arbitrarily. XRD of composite bone cement as figure 1 As shown, the surface SEM as figure 2 As shown, the SEM of mineralized deposits as image 3 shown.

Embodiment 2

[0023] After weighing 90 mesh and 10g of a powder, weigh b powder chitosan (CS) to 0.9g, mix and grind a composite powder and b chitosan evenly; weigh 0.86g polyvinyl alcohol (molecular weight 70000) Put it into 100ml of deionized water, heat at 95°C and stir until the polyvinyl alcohol is completely dissolved into liquid c, then use a pipette gun to absorb 3.00ml of the dissolved c solution and add it to the evenly ground a / b powder, mix and stir evenly It is in the form of a paste, which can be shaped and used arbitrarily.

Embodiment 3

[0025] After weighing 90 mesh and 10g of a powder, weigh b powder chitosan (CS) to 1.00g, mix and grind a composite powder and b chitosan evenly; weigh 1.88g polyvinyl alcohol (molecular weight 80000) Put it into 100ml of deionized water, heat at 95°C and stir until the polyvinyl alcohol is completely dissolved into liquid c, then use a pipette gun to absorb 3.20ml of the dissolved c solution and add it to the uniformly ground a / b powder, mix and stir evenly It is in the form of a paste, which can be shaped and used arbitrarily. The SEM of the obtained composite bone cement is as follows: image 3 shown.

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Abstract

The invention belongs to the field of medical bone repair materials, and particularly relates to injection type degradable high-mineralization-activity composite bone cement and a preparation method thereof. The composite bone cement has double biomineralization activities of calcium citrate and amorphous calcium phosphate, and due to excellent bioactivity, surface and interface bonding between ahost bone and an implant is promoted, so that a place capable of crawling, climbing and growing is provided for growth and proliferation of osteoblasts; thus, newly-generated natural bone tissue in aspecific shape is formed in the area where bone cement is implanted originally, and the bone defect part is repaired in time. Due to the biomacromolecule auxiliary effect of CS and PVA, the collapse resistance is improved, the compressive strength is excellent, the injectable performance is excellent, the requirement of bone cement research at present is met, injectable degradation and improvementand optimization balance of biological activity and physical performance are achieved, and more selections are provided for a bone cement material system.

Description

technical field [0001] The invention belongs to the field of medical biomaterials, and in particular relates to an injection-type degradable high mineralization activity composite bone cement and a preparation method thereof. Background technique [0002] Injectable bone filling materials have important application value in orthopedic surgery, especially minimally invasive surgery. At present, injectable bone filling materials have been used in orthopedic surgery fields such as filling of bone defects, joint prosthesis fixation, and percutaneous vertebroplasty. Polymethyl methacrylate (PMMA) system injectable bone filling material is currently the most widely used injectable bone filling material, even the only clinically used injectable bone filling material in percutaneous vertebroplasty and other treatments . However, it has poor degradability and lack of effective osseointegration performance, so its smooth surface has poor bonding strength with the surrounding bone ti...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/58A61L27/48A61L27/54
CPCA61L27/58A61L27/48A61L27/54A61L2400/06A61L2300/102A61L2300/21A61L2300/604
Inventor 李峻峰杨亚楠张馨银悦王皓王立邹琴赖雪飞
Owner CHENGDU UNIVERSITY OF TECHNOLOGY