Multifunctional composite anti-adhesion material and preparation method thereof

Abstract

The invention provides a multifunctional composite anti-adhesion material and a preparation method thereof. The multifunctional composite anti-adhesion material is composed of an anti-adhesion layer and a hemostatic layer, wherein the anti-adhesion layer is an anti-adhesion membrane prepared from carboxymethyl chitosan; and the hemostatic layer is hemostatic sponge obtained by cross-linking and mixing quaternary ammonium salt chitin / quaternary ammonium salt chitosan and gelatin through genipin and performing freeze-drying. The multifunctional composite anti-adhesion material provided by the invention is a medical material for resisting adhesion after a surgical operation and also has the excellent characteristics of hemostasis, antibiosis, healing promotion, in-vivo degradation, biocompatibility and the like; the hemostatic layer is naturally degraded earlier than peritoneum healing and the anti-adhesion layer, so that the situation that the curative effect is reduced or even adhesionis aggravated is avoided, and the curative effect of the anti-adhesion material is ensured; and meanwhile, the multifunctional composite anti-adhesion material has a composite form and a separation form, so that a surgeon can select and use the multifunctional composite anti-adhesion material conveniently according to actual conditions in the operation.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and in particular relates to a multifunctional composite anti-adhesion material and a preparation method thereof. Background technique [0002] Adhesion is a common complication after surgery. Clinical statistics show that more than 50% of patients undergoing abdominal surgery will have abdominal adhesions. The occurrence of adhesions will further lead to complications such as chronic pelvic abdominal pain, adhesive ileus, infertility, etc. It is very painful, and in severe cases, it may even require reoperation to remove adhesions. The anti-adhesion methods currently adopted clinically include placing physical barriers after surgery, minimally invasive surgery to reduce damage, and application of drugs to reduce fibrin deposition. However, abdominal tissue and peritoneal damage caused by minimally invasive surgery are still unavoidable. There is a risk of hemorrhage in drug treatment, and ch...

AI Technical Summary

Problems solved by technology

The anti-adhesion methods currently adopted clinically include placing physical barriers after surgery, minimally invasive surgery to reduce damage, and application of drugs to reduce fibrin deposition. However, abdominal tissue and peritoneal damage caused by minimally invasive surgery are still unavoidable. There is a risk of hemorrhage in drug treatment, and choosing appropriate materials to cover the wound is the focus of current anti-adhesion research

The problem facing the widely used medical anti-adhesion products today is that while the anti-adhesion materials activate the fibrinolytic system to promote the decomposition of fibrinogen, they also increase the risk of surgical wound bleeding. Therefore, the anti-adhesion products represented by INTERCEED anti-adhesion film Jr GW B, Shomento S. Adhesion prevention in patients with multiple cesarean deliveries [J]. American Journal of Obstetrics & Gynecology, 2011, 205 (6-supp-S): 0-0.

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