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Process for preparing D-glucosamine hydrochloride from biomass

A technology of glucosamine hydrochloride and biomass, which is applied in the preparation of amino sugars, sugar derivatives, sugar derivatives, etc., to achieve the effects of improving the utilization rate of raw materials, increasing the yield, and promoting hydrolysis

Active Publication Date: 2021-03-30
SHANDONG RUNDE BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In view of the above problems, the present invention provides a technique for preparing D-glucosamine hydrochloride from biomass, which effectively reduces the need to use a large amount of D-glucosamine in the traditional process of using biomass such as shrimp shells and crab shells Problems caused by strong acids and alkalis

Method used

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  • Process for preparing D-glucosamine hydrochloride from biomass

Examples

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Comparison scheme
Effect test

Embodiment 1

[0028] A kind of technique that utilizes biomass to prepare D-glucosamine hydrochloride comprises the steps:

[0029] (1) Wash the shrimp shells with clean water, then dry them at 50°C until there is no obvious residual moisture on the surface of the shrimp shells, then mix the shrimp shells with hydrochloric acid with a mass concentration of 15% to decalcify the shrimp shells, and wait until there is no residual moisture in the shrimp shells. Add excess sodium carbonate (mass concentration is 25%) after the air bubbles are exposed, then the reaction system is heated to 80 ℃ for further degreasing and deproteinization of the shrimp shells, and the shrimp shells are filtered out and the residues on the surface are removed by washing the shrimp shells with clear water, and then at 50 Dry the shrimp shells at ℃ to obtain chitin for later use.

[0030] (2) The chitin, ammonium chloride, ethanol and water obtained in step (1) are used to form a reaction system together, and the rea...

Embodiment 2

[0034] A kind of technique that utilizes biomass to prepare D-glucosamine hydrochloride comprises the steps:

[0035] (1) Wash the shrimp shells with clean water, then dry them at 55°C until there is no obvious residual moisture on the surface of the shrimp shells, and then mix the shrimp shells with hydrochloric acid with a mass concentration of 15% to decalcify the shrimp shells. Add excess sodium carbonate (mass concentration is 35%) after the air bubbles are exposed, then the reaction system is heated to 75 ℃ for further degreasing and deproteinization of the shrimp shells, and the shrimp shells are filtered out and the residues on the surface are removed by washing the shrimp shells with clear water, and then at 55 Dry the shrimp shells at ℃ to obtain chitin for later use.

[0036] (2) The chitin, ammonium chloride, ethanol and water obtained in step (1) are used to form a reaction system together, and the reaction system is placed in a high-pressure reactor with a polyte...

Embodiment 3

[0040] A kind of technique that utilizes biomass to prepare D-glucosamine hydrochloride comprises the steps:

[0041] (1) Wash the shrimp shells with clean water, then dry them at 60°C until there is no obvious residual moisture on the surface of the shrimp shells, and then mix the shrimp shells with hydrochloric acid with a mass concentration of 20% to decalcify the shrimp shells. Add excess sodium carbonate (mass concentration is 30%) after the air bubbles are exposed, then the reaction system is heated to 70°C for further degreasing and deproteinization of the shrimp shells, and the shrimp shells are filtered out and the residues on the surface are removed by washing the shrimp shells with clear water, then at 60 Dry the shrimp shells at ℃ to obtain chitin for later use.

[0042] (2) The chitin, ammonium chloride, methanol and water obtained in step (1) are used to form a reaction system together, and the reaction system is placed in a high-pressure reactor with a polytetra...

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Abstract

The invention relates to the technical field of glucosamine preparation, in particular to a process for preparing D-glucosamine hydrochloride from biomass. The process comprises the following steps: (1) cleaning shrimp shells and / or crab shells, drying, adding hydrochloric acid to decalcify, adding excessive sodium carbonate, heating to react, and washing and drying the shrimp shells and / or crab shells to obtain crustacean shells; (2) reacting chitin, ammonium chloride, volatile organic alcohol and water at high temperature and high pressure to obtain hydrolysate; and (3) mixing the hydrolysate obtained in the step (2) with activated carbon, mixing the decolorized hydrolysate with excessive sodium hydroxide, then carrying out heating reaction, and then adjusting the pH value of the reaction solution by adopting hydrochloric acid to obtain a glucosamine hydrochloride solution; and (4) drying the glucosamine hydrochloride solution to obtain the glucosamine hydrochloride. The process effectively reduces the problems caused by a large amount of strong acids and strong alkalis required in the traditional process of preparing D-glucosamine from shrimp shells, crab shells and other biomasses.

Description

technical field [0001] The invention relates to the technical field of glucosamine preparation, in particular to a process for preparing D-glucosamine hydrochloride from biomass. Background technique [0002] D-glucosamine (C 6 h 13 NO 5 ), which can overstimulate the biochemical synthesis of mucopolysaccharides and increase the calcium intake of bones, and improve the metabolic function and nutrition of bone and cartilage tissues. Therefore, D-glucosamine has been widely used in the treatment and prevention of osteoarthritis. In addition, due to the poor stability of D-glucosamine in the air, it is generally stored and used in the form of D-glucosamine hydrochloride in actual production. [0003] The D-type in nature mainly exists in the form of N-acetylglucosamine in chitin, mucus polysaccharides, glycoproteins, glycolipids, and the murein of bacterial cell walls. Therefore, shrimp shells and crab shells are often used As a raw material for preparing D-glucosamine, chi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07H1/00C07H1/06C07H5/06
CPCC07H1/00C07H1/06C07H5/06
Inventor 许可卢健行张新平张建华韩宁柏帅吴祥舟
Owner SHANDONG RUNDE BIOTECH CO LTD
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