Pharmaceutical composition and application thereof

A technology of composition and medicine, which is applied in the field of preparation of drugs for the treatment of type 2 diabetes, can solve problems such as the treatment of type 2 diabetes, and achieve complex preparation effects

Active Publication Date: 2021-04-20
CHINA PHARM UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] At present, there is no report on the related effects of Zengye Decoction components and its composition on type 2 diabetes, and there is no report on the treatment of type 2 diabetes on the composition composed of the above active ingredients

Method used

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  • Pharmaceutical composition and application thereof
  • Pharmaceutical composition and application thereof
  • Pharmaceutical composition and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033]Example 1 Preparation of six pharmaceutical compositions of verbascoside, harpaside, harpagoside, cinnamic acid, p-coumaric acid, and ferulic acid

[0034] 1. Materials: Reference substance: Acteoside (acteoside), harpagide (harpagide), harpagoside (harpagoside) was purchased from Sichuan Weikeqi Biotechnology Co., Ltd. (purity ≥ 98%), cinnamic acid (cinnamic acid) , p-coumaric acid (p-coumaric acid), ferulic acid (ferulic acid) were purchased from Chengdu Puruifa Technology Development Co., Ltd., and the purity of the reference substance was above 98%. Scrophulariaceae, Shengdi, Ophiopogon japonicus (Nanjing Traditional Chinese Medicine Outpatient Department), Methanol (Shanghai Xingke High-Purity Solvent Co., Ltd.), Acetonitrile (Germany Merck Company), Formic Acid (Aladdin Biochemical Technology Co., Ltd.), Pure Water (Watsons Drinking Water Co., Ltd.), n-butanol (Sinopharm Chemical Reagent Co.Ltd).

[0035] 2. Instruments: Milli-Q ultrapure water instrument (Millipo...

Embodiment 2

[0045] Example 2 Effects of harbaside, harpagoside, verbascoside, cinnamic acid, ferulic acid, and p-coumaric acid composition on type 2 diabetic rats

[0046] 1. Materials: high-fat feed (Jiangsu Synergy Pharmaceutical Bioengineering Co., Ltd.), streptozotocin (STZ, Germany BIOFoxx company), rat INS assay kit (Shanghai Kejian Biological Co., Ltd.) glucose (α- D-Glucose, Aladdin Company), Metformin Hydrochloride Tablets (Sino-US Shanghai Bristol-Myers Squibb Pharmaceutical Co., Ltd.), glycogen content, glycosylated serum protein (GSP), total cholesterol (T-CHO), triglyceride (TG), low density Lipoprotein (LDL-C) assay kits were purchased from Nanjing Jiancheng Bioengineering Institute. Test drug is the pharmaceutical composition solution prepared in Example 1.

[0047] 2. Instruments: microplate reader (Bio-Tek, USA), cryogenic centrifuge (Thermo), blood glucose meter (Roche Diagnostics Co., Ltd., Germany), PHS-3BWpH meter (Shanghai Bant Instrument Co., Ltd.).

[0048] 3. Dr...

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Abstract

The invention relates to a pharmaceutical composition and application thereof. The pharmaceutical composition mainly comprises harpagide, harpagoside, verbascoside, cinnamic acid, ferulic acid and p-coumaric acid. The pharmaceutical composition disclosed by the invention can reduce fasting blood glucose and glycated serum protein levels and improve the blood glucose regulation capability; the dyslipidemia is regulated, and the blood lipid metabolism is improved; the insufficiency of insulin secretion is relieved; and the insulin resistance level is improved, the body insulin sensitivity is increased, and the effect of protecting islet cells is achieved. Therefore, the pharmaceutical composition disclosed by the invention has a relatively good effect of improving the type 2 diabetes mellitus and can be used for preparing a medicine for treating the type 2 diabetes mellitus.

Description

technical field [0001] The invention relates to a pharmaceutical composition, in particular to a pharmaceutical composition and its application in the preparation of medicines for treating type 2 diabetes. Background technique [0002] Type 2 diabetes mellitus (T2DM) is the most common type of diabetes, which accounts for more than 90% of all diabetic patients. It is a metabolic syndrome with a very complex pathophysiological basis. Sensitivity is reduced. [0003] At present, the clinically used drugs for the treatment of T2DM mainly include biguanides, glinides, thiazolidinones, sulfonylureas, α-glucosidase inhibitors, glucagon-like peptide-1 analogues, DPP-4 Inhibitors, insulin and other chemical drugs are often accompanied by different types and degrees of side effects; and as the number of diabetic patients increases year by year, the medical expenses for diabetes treatment increase year by year. Therefore, the development of new safer and less toxic side effects Drug...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61P3/10A61P3/06A61K31/7034A61K31/192
Inventor 戚进李鑫琦张静雯常山泉
Owner CHINA PHARM UNIV
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