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Amoxicillin and clavulanate potassium capsule and preparation method thereof

A technology of amoxicillin clavulanate potassium and amoxicillin, which is applied in the field of medicine, can solve the problems of poor stability of clavulanate potassium, reduced drug efficacy, difficulty in taking, etc., and can shorten the onset time, improve the taste, and prolong the storage. effect of time

Active Publication Date: 2021-04-27
APELOA PHARM CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The present invention aims to overcome the existing amoxicillin-clavulanate-potassium compound preparation, because the stability of clavulanate-potassium is relatively poor, it is easy to decompose when meeting water, and the clavulanate-potassium in the existing dosage form is exposed in the air, It is easy to absorb moisture in the air and decompose, thereby reducing the efficacy of the drug; and when the existing dosage form is taken, the drug directly contacts the oral cavity, and the taste is not good, which will cause difficulty in taking it. A kind of amoxicillin clavulanate potassium capsule is provided and the preparation method thereof, the amoxicillin-clavulanate potassium compound preparation is made into a capsule form, which can effectively prevent the active ingredient from decomposing during placement, so that the drug effect can be maintained for a long time; and the active ingredient in the capsule can be effectively dissolved in the intestinal tract , to ensure consistent release of active ingredients

Method used

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  • Amoxicillin and clavulanate potassium capsule and preparation method thereof
  • Amoxicillin and clavulanate potassium capsule and preparation method thereof
  • Amoxicillin and clavulanate potassium capsule and preparation method thereof

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Embodiment 1

[0037] A potassium amoxicillin-clavulanate capsule comprises main materials and auxiliary materials filled in hollow capsules. The main ingredients include: 125mg of amoxicillin and 31.25mg of potassium clavulanate; the excipients include: 60mg of microcrystalline cellulose, 8mg of silicon dioxide, 8mg of talc, and 2mg of magnesium stearate.

[0038] The preparation method of above-mentioned Potassium Amoxicillin-Clavulanate Capsules, comprises the steps:

[0039] (1) passing the main ingredients amoxicillin and potassium clavulanate through a 40-mesh sieve for subsequent use;

[0040] (2) After drying the auxiliary materials microcrystalline cellulose, silicon dioxide, talc powder and magnesium stearate respectively, pass through a 40-mesh sieve for subsequent use;

[0041] (3) Weigh 125.0g of amoxicillin, 33.125g of potassium clavulanate, 60.0g of microcrystalline cellulose, 8.0g of silicon dioxide, 8.0g of talcum powder, and 2.0g of magnesium stearate and mix them uniforml...

Embodiment 2

[0049] A potassium amoxicillin-clavulanate capsule comprises main materials and auxiliary materials filled in hollow capsules. Main ingredients include: 120mg amoxicillin and 31mg potassium clavulanate; excipients include: 55mg microcrystalline cellulose, 5mg silicon dioxide, 5mg talc, 1mg magnesium stearate.

[0050] The preparation method of above-mentioned Potassium Amoxicillin-Clavulanate Capsules, comprises the steps:

[0051] (1) passing the main ingredients amoxicillin and potassium clavulanate through a 40-mesh sieve for subsequent use;

[0052] (2) After drying the auxiliary materials microcrystalline cellulose, silicon dioxide, talc powder and magnesium stearate respectively, pass through a 40-mesh sieve for subsequent use;

[0053] (3) Weigh 120.0 g of amoxicillin, 32.55 g of potassium clavulanate, 55.0 g of microcrystalline cellulose, 5.0 g of silicon dioxide, 5.0 g of talcum powder, and 1.0 g of magnesium stearate and mix uniformly to obtain a filler;

[0054] (...

Embodiment 3

[0061] A potassium amoxicillin-clavulanate capsule comprises main materials and auxiliary materials filled in hollow capsules. The main ingredients include: 130mg of amoxicillin and 31.5mg of potassium clavulanate; the excipients include: 65mg of microcrystalline cellulose, 10mg of silicon dioxide, 10mg of talc, and 3mg of magnesium stearate.

[0062] The preparation method of above-mentioned Potassium Amoxicillin-Clavulanate Capsules, comprises the steps:

[0063] (1) passing the main ingredients amoxicillin and potassium clavulanate through a 40-mesh sieve for subsequent use;

[0064] (2) After drying the auxiliary materials microcrystalline cellulose, silicon dioxide, talc powder and magnesium stearate respectively, pass through a 40-mesh sieve for subsequent use;

[0065] (3) Weigh 130.0g of amoxicillin, 33.7g of potassium clavulanate, 65.0g of microcrystalline cellulose, 10.0g of silicon dioxide, 10.0g of talcum powder, and 3.0g of magnesium stearate and mix them uniform...

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Abstract

The invention discloses an amoxicillin and clavulanate potassium capsule. The amoxicillin and clavulanate potassium capsule comprises a main material and an auxiliary material, wherein the main material and the auxiliary material fills a hollow capsule prepared from hydroxypropyl methyl cellulose derivatives; the main material comprises the following components in parts by weight: 120-130 parts of amoxicillin and 31-31.5 parts of clavulanate potassium; and the auxiliary material comprises the following components in parts by weight: 55-65 parts of microcrystalline cellulose, 5-10 parts of silicon dioxide, 5-10 parts of talcum powder and 1-3 parts of magnesium stearate. The amoxicillin and clavulanate potassium compound preparation is prepared into a capsule form, so that active ingredients can be effectively prevented from being decomposed in the placing process, and the drug effect can be kept for a long time; and the active ingredients in the capsule can be effectively dissolved out in the intestinal tract, so that the release consistency of the active ingredients is ensured.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a potassium amoxicillin-clavulanate capsule and a preparation method thereof. Background technique [0002] Amoxicillin is a broad-spectrum antibiotic that produces a bactericidal effect by inhibiting the synthesis of bacterial cell walls. It is currently widely used in the treatment of respiratory tract, urinary tract, biliary tract infections and typhoid fever caused by sensitive bacteria. However, after long-term application, some bacteria develop resistance to amoxicillin due to the production of β-lactamase that can hydrolyze it. Although clavulanic acid itself has weak antibacterial activity, it has a strong broad-spectrum β-lactamase inhibitory effect, which can protect β-lactam antibiotics from being hydrolyzed and inactivated, thereby strengthening their antibacterial effect. After the two are compatible to make a compound preparation, the presence of clavulanic acid prevents am...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/48A61K31/424A61K31/43A61K47/38A61K47/04A61K47/02A61P31/04C08B13/00
CPCA61K31/43A61K31/424A61K9/4866A61K9/485A61K9/4891A61K9/4816A61P31/04C08B13/00A61K2300/00
Inventor 沈勇李世彩罗川王朝胜
Owner APELOA PHARM CO LTD