High-air-permeability degradable drug-loaded skin wound dressing and preparation method thereof

Abstract

The invention discloses a high-air-permeability degradable drug-loaded skin wound dressing and a preparation method thereof. The dressing comprises a dressing inner layer, a dressing outer layer and a repairing colloid layer, wherein the repairing colloid layer is located between the dressing inner layer and the dressing outer layer; the dressing inner layer is obtained by performing electrostatic spinning on an inner layer spinning solution; and the dressing outer layer is obtained by performing electrostatic spinning on an outer layer spinning solution. The used material of the dressing are safe and non-toxic, the biodegradation rate is high, the pollution to the environment is avoided, and environmental pollution caused by medical waste can be effectively relieved. The dressing is simple in preparation process, mild in reaction condition and high in safety, is very suitable for industrial production, and has high economic value and environmental protection value.

Description

technical field [0001] The invention relates to the technical field of wound dressings, in particular to a highly air-permeable and degradable drug-loaded skin wound dressing and a preparation method thereof. Background technique [0002] The skin is the largest organ of the human body. It can maintain the stability of the internal environment of the human body, prevent the invasion of microorganisms, protect the safety of important tissues such as blood vessels and nerves in the human body, and is of great significance to the normal progress of human physiological activities. However, human skin will inevitably suffer some damage in daily life and labor. After a certain period of cultivation, the wound will heal itself, but the process of wound healing is complicated and slow. If it is not well maintained, it is easy to cause inflammation, gangrene, etc. question. Reducing wound exudate, preventing wound bacterial infection, maintaining a stable wound microenvironment, and...

AI Technical Summary

Problems solved by technology

Although the most commonly used wound dressings such as gauze and cotton towels can absorb wound exudate to a certain extent and prevent wound infection, they have poor antibacterial performance and insufficient hemostatic ability. The dressing is easy to stick to the wound and difficult to replace. And other problems, it is easy to aggravate the pain of the patient, cause secondary injury to the wound, prolong the wound healing time, and it is difficult to meet the needs of the patient; and some synthetic fiber dressings have poor air permeability, poor ability to absorb exudate, and are easy to breed bacteria. limit its development

[0004] Electrospun fibers have a high aspect ratio and a large specific surface area, high surface porosity, good air permeability, and are very suitable for making wound dressings; when people use nanofibers to prepare wound dressings, in order to improve their wound Repair efficiency, often adding drugs or drug-loaded microspheres that can promote wound healing to the nanofibers; the method of directly mixing the drugs with the spinning solution not only tends to reduce the medicinal effect of the drugs, but also affects the mechanical properties of the nanofibers However, the nanofibers made by directly mixing the drug-loaded microspheres with the spinning solution still have problems such as poor compatibility between the drug-loaded microspheres and the nanofibers, resulting in low mechanical strength of the nanofibers, easy breakage, and insufficient air permeability.

Thousands of tons of wound dressings are consumed in our country every year. These discarded wound dressings are usually landfilled or stacked in the open air after use. Whether they are landfilled or stacked in the open air, they will cause great pressure on our environment and deplete land resources. waste

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