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High-adhesion composite hydrogel with synergism between strong hydrogen bonds and cation-pi interaction, and preparation method thereof

A composite hydrogel and cation technology, which is applied in the fields of pharmaceutical formulation, coating, and medical science, can solve the problems of complex operation, common method of high adhesion of difficult hydrogel, etc., and achieve simple preparation process, excellent adhesion With the effect of simple performance and process conditions

Active Publication Date: 2021-05-25
HUBEI UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Gong research group [Takahashi R, Shimano K, Gong J P, et al. Tough particle-based double network hydrogels for functional solid surface coatings [J]. Advanced Materials Interfaces, 2018, 5 (23): 1801018.] designed a functional For solid surface-coated particle double network hydrogel (P-DN), the first network poly 2-acrylamide-2-methylpropanesulfonic acid (PAMPS) is dried and crushed into particles, and then soaked into the second network Monomer acrylamide (AAm) solution, prepolymerized solution coated onto a non-porous solid surface containing polyvinyl acetate (PVAc) and initiator, passed through PVAc in solid substrate and PAAm in P-DN hydrogel The covalent interaction between the polymer chains forms a strong adhesion. When the interface between the gel and the substrate is destroyed, the first layer of network particles acts as a "sacrificial bond" to dissipate part of the energy, and the P-DN hydrogel exhibits high performance. Adhesion performance (more than 1000J m -2 ), this method is complicated to operate, and it is difficult to become a general method for high adhesion of hydrogels

Method used

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  • High-adhesion composite hydrogel with synergism between strong hydrogen bonds and cation-pi interaction, and preparation method thereof
  • High-adhesion composite hydrogel with synergism between strong hydrogen bonds and cation-pi interaction, and preparation method thereof
  • High-adhesion composite hydrogel with synergism between strong hydrogen bonds and cation-pi interaction, and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Step 1): Weigh DAC, VDT, MBAA, and KA and dissolve them in 10 mL of dimethyl sulfoxide, and stir in a water bath at 70°C for 30 min under light-shielding conditions to obtain a uniform mixed solution, so that in the obtained mixed solution, DAC The concentration is 315 mg / mL, the VDT is 151 mg / mL, the molar weight of MBAA accounts for 0.5% of the total molar amount of the monomers, and the molar amount of KA accounts for 0.25% of the total molar amounts of the monomers.

[0024] Step 2): inject the mixed solution obtained in step 1) into a glass mold under light-shielding conditions, and place it under an ultraviolet light for 12 hours to obtain a strong hydrogen bond and cation π synergistic high-adhesion composite hydrogel film.

[0025] The hydrogel material obtained in this embodiment and the glass press figure 2 For the lap joint shown, the adhesion force is 6.2N and the adhesion strength is 15.4kPa as measured by the adhesion shear strength test using an electron...

Embodiment 2

[0027] Step 1): Weigh DAC, VDT, MBAA, and KA and dissolve them in 10 mL of dimethyl sulfoxide, and stir in a water bath at 70°C for 30 min under light-shielding conditions to obtain a uniform mixed solution, so that in the obtained mixed solution, DAC The concentration is 291 mg / mL, the VDT is 156 mg / mL, the molar weight of MBAA accounts for 0.1% of the total molar amount of the monomers, and the molar amount of KA accounts for 0.25% of the total molar amounts of the monomers.

[0028] Step 2): inject the mixed solution obtained in step 1) into a glass mold under light-shielding conditions, and place it under an ultraviolet light for 12 hours to obtain a strong hydrogen bond and cation π synergistic high-adhesion composite hydrogel film.

[0029] The hydrogel material obtained in this embodiment and the glass press figure 2 For the lap joint shown, the adhesion force is 7.8N and the adhesion strength is 17.3kPa as measured by the adhesion shear strength test using an electron...

Embodiment 3

[0031] Step 1): Weigh DAC, VDT, MBAA, and KA and dissolve them in 10 mL of dimethyl sulfoxide, and stir in a water bath at 70°C for 30 min under light-shielding conditions to obtain a uniform mixed solution, so that in the obtained mixed solution, DAC The concentration is 291 mg / mL, the VDT is 156 mg / mL, the molar weight of MBAA accounts for 0.5% of the total molar amount of the monomers, and the molar weight of KA accounts for 0.25% of the total molar amounts of the monomers.

[0032] Step 2): inject the mixed solution obtained in step 1) into a glass mold under light-shielding conditions, and place it under an ultraviolet light for 12 hours to obtain a strong hydrogen bond and cation π synergistic high-adhesion composite hydrogel film.

[0033] The hydrogel material obtained in this embodiment and the glass press figure 2 For the lap joint shown, the adhesion force is 9.3N and the adhesion strength is 24.6kPa as measured by the adhesion shear strength test using an electron...

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Abstract

The invention discloses a preparation method of a high-adhesion composite hydrogel with synergism between strong hydrogen bonds and cation-pi interaction. The preparation method comprises the following steps: dissolving DAC, VDT, a chemical cross-linking agent and a photoinitiator by adopting a one-pot method to obtain a uniform mixed solution, and initiating polymerization under the condition of ultraviolet irradiation to obtain the P(DAC-co-VDT) composite hydrogel. According to a formed composite membrane, interaction between cations and triazine pi and strong hydrogen bond interaction between VDT and VDT can be respectively formed, and the two interactions cooperate with each other to obtain high bonding strength of the hydrogel membrane. While high bonding strength is obtained, a cationic copolymerization unit can form strong electrostatic interaction with most negatively charged surfaces such as glass, plastic and biological tissues, and meanwhile, a VDT part can also form strong hydrogen-bond interaction with hydroxyl groups between substrates, so high bonding strength can be obtained. The method is expected to become a general method for achieving high adhesion of composite hydrogel with synergism between strong hydrogen bonds and cation-pi interaction.

Description

technical field [0001] The invention relates to the technical field of polymer materials, in particular to a method for preparing a strong hydrogen bond and cation π synergistic high-adhesion composite hydrogel P (DAC-co-VDT). Background technique [0002] Hydrogel is a new type of polymer material, which is a three-dimensional network composed of hydrophilic polymers, with a wide range of properties including high water content, high deformability, structural similarity with biological tissues, and potential functionalization. , making it widely used in underwater soft robots, human implantable devices, wound dressings, tissue engineering, and drug delivery, which require hydrogels to be firmly adhered to substrate surfaces in both dry and wet environments superior. However, hydrogels generally have smooth surfaces and weak adhesion properties, which cannot meet the application requirements. In order to make the hydrogel firmly adhere to the surface of the material, Yuk e...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F220/34C08F226/06C08F222/38C08F2/48A61L31/10A61L31/14
CPCC08F220/34C08F2/48A61L31/10A61L31/145A61L2400/18A61L2420/02C08F226/06C08F222/385C08L33/14
Inventor 李学锋彭雪银龙世军陈梦繁王永林陈顺兰邱积武
Owner HUBEI UNIV OF TECH
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