Novel tangerine pith extract and preparation method and medical use thereof in improving intestinal flora

The technology of extract and citrus is applied in the field of novel citrus tangerine complex extract and its preparation method and the medical application field of improving the effect of intestinal flora, and can solve the problems of reduced pectin activity and the like

Inactive Publication Date: 2021-07-23
哈尔滨百世普康生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It adopts the method of cutting the straight chain of pectin to reduce the molecular weight, which will reduce the activity of pectin

Method used

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  • Novel tangerine pith extract and preparation method and medical use thereof in improving intestinal flora
  • Novel tangerine pith extract and preparation method and medical use thereof in improving intestinal flora
  • Novel tangerine pith extract and preparation method and medical use thereof in improving intestinal flora

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] like Figure 8 A method for preparing the citrus complex extract shown, the method comprises the following steps:

[0046] 1) Handling of raw materials

[0047] After the citrus is crushed, washed and dried, it enters the acid extraction tank and is heated to 40-50°C. The pH is adjusted to 3.5-4.5 with acid (HC1), and the temperature is kept for 4 hours.

[0048] 2) filter

[0049] The liquid after leaching is filtered to remove the residue, the filtrate is taken into the extraction tank, and the filter residue is subjected to secondary leaching.

[0050] 3) Extraction

[0051] The extracted liquid enters the extraction tank, and the extract is added to carry out the extraction of polymer pectin, and the extracted extract enters the pressing device to obtain polymer pectin.

[0052] 4) Recover the extract

[0053] The extract is recovered through an extraction recovery device, and the remaining part of the extract is the raw material liquid of small molecule pectin...

Embodiment 2

[0061] 1.1 Materials

[0062] Obtained in Example 1, the finished product is a brown suspension. After determination, every 100ml contains 32000mg of small molecule pectin, 3400mg of citrus flavonoids (VP), and the total solid content is 4500mg.

[0063] 1.2 Animals and Grouping

[0064] 150 clean-grade (II-level) Kunming male mice weighing 22-25 g were provided by the Experimental Animal Center of the Academy of Military Medical Sciences. Set up three doses of 0.2, 0.4, 0.8ml / (25g bw) (equivalent to 5, 10, 20 times the recommended dose of the human body) experimental groups, and set up a constipation model control group and a negative control group at the same time, with 15 rats in each group animal.

[0065] 1.3 Method

[0066] According to the "Technical Specifications for Inspection and Evaluation of Health Food" (2003 Edition), "test method for laxative function", the specific method is as follows:

[0067] 1.3.1 Small intestine motility test

[0068] Each experimen...

Embodiment 3

[0094] Example 3 Effect of small molecule pectin from citrus tangerine on intestinal mucosal barrier function

[0095] grouping of experimental mice

[0096] AC group is a blank control group, a healthy group;

[0097] AA group is the model control group, the group of patients with dysbacteriosis;

[0098] The TC group is a negative control, and the healthy group eats normally;

[0099] The TA group was a group with dysbacteriosis but was given a normal diet;

[0100] The TP group is a treatment group given to the small molecule pectin (produced by Hangzhou Luotong Biotechnology Co., Ltd.) of the citrus extract of the present invention;

[0101] 1. Indicators of short-chain fatty acids

[0102] Short-chain fatty acids (SCFA) are of great significance to human health. They can affect the transport of colonic epithelial cells, promote the metabolism, growth, and differentiation of colonic cells and small intestinal cells, and provide energy for intestinal mucosal epithelial ...

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Abstract

The invention relates to the field of medicines, food and health-care products, in particular to a novel tangerine pith extract and a preparation method and medical use thereof in improving intestinal flora. The novel tangerine pith extract comprises micromolecular pectin and citrus flavonoids which are prepared by physically separating extract liquid obtained after high-molecular pectin is extracted from tangerine pith, and every 100 ml of the extract contains Js2000 mg of micromolecular pectin and Js400 mg of citrus flavonoids. The invention also discloses use of tangerine pith micromolecular pectin in preparing medicines, food or health-care products for moistening intestine and relaxing bowel, regulating intestinal flora or improving a barrier function of intestinal mucosa.

Description

technical field [0001] The invention relates to the fields of medicine, food and health care products, in particular to a novel citrus extract, a preparation method thereof and a medical application for improving intestinal flora. Background technique [0002] Citrus pectin is a polysaccharide derived from plant cell walls. It can generally be used as a food additive. It has good gelling, stabilizing, emulsifying, thickening, and suspending functions. Similarly, natural citrus pectin has a large molecular weight (5-300,000 Da ), cannot be absorbed by the intestine after eating and cannot make it fully function in the body. In view of this, modifying the size and structure of its molecules has the prospect of enhancing biological functions. [0003] Several main methods of pectin modification, including chemical (pH) modification, enzyme modification, thermal modification, irradiation modification, graft modification, cross-linking modification and substitution modification;...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/732A61K36/752A61P1/10A61P1/00A23L33/105A23L33/125
CPCA23V2002/00A61K31/732A61K36/752A61K2236/33A61K2236/53A23L33/105A23L33/125A61P1/00A61P1/10A61K2300/00A23V2200/3204A23V2200/30A23V2200/308A23V2250/21162A23V2250/21A23V2250/5072
Inventor 李悦付娜
Owner 哈尔滨百世普康生物科技有限公司
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