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Tubular PTFE covered stent and preparation method thereof

A stent-graft, PTFE technology, applied in stents, coatings, filament/wire forming, etc., can solve the problem of little research on vascular stent covering, and achieve good water permeability, good mechanical properties, and blood compatibility. good effect

Pending Publication Date: 2021-07-23
SUZHOU UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are few studies on the preparation of vascular stent grafts by electrospinning technology.

Method used

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  • Tubular PTFE covered stent and preparation method thereof
  • Tubular PTFE covered stent and preparation method thereof
  • Tubular PTFE covered stent and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] 1. Preparation of PTFE / PEO precursor membrane

[0038] Weigh an appropriate amount of PEO powder with an Adventurer electronic balance (Changzhou Ohaus Instrument Co., Ltd.) and add it to deionized water and stir it with a 84-1 magnetic stirrer (Shanghai Meiyingpu Instrument Manufacturing Co., Ltd.) until it is completely dissolved to obtain 4wt% PEO water solution. Weigh the PTFE dispersion emulsion, mix the PEO aqueous solution and the deionized water, stir continuously until uniform, and obtain the electrospinning solutions with different ratios of PTFE / PEO. The spinning solution was introduced into a 5mL syringe, and the mandrel (4 mm in diameter) wrapped with a stainless steel braided sleeve was used as a receiving device for electrospinning (JDS02 electrospinning machine, Changsha Nano Instrument Technology Co., Ltd.), and the setting Electrospinning parameters are: voltage 15kV, injection speed 8μL / min, receiving distance 20cm, receiver speed 400r / min, relative ...

Embodiment 2

[0045] The difference between Example 2 and Example 1 is that the TPU electrospinning method is used to prepare the stent graft, and the specific operations are as follows:

[0046] Weigh an appropriate amount of TPU powder and dissolve it in DMF and stir until it is completely dissolved to obtain a 30wt% TPU electrospinning solution. Set the electrospinning parameters: the voltage is 16-17kV, and the mandrel wrapped with a metal bracket is used as the receiving device. The receiving distance is 15cm, the flow rate is 13.33μL / min, after a certain period of electrospinning, a tubular TPU electrospun membrane is obtained; then the above-mentioned sintered tubular PTFE film is placed outside the TPU electrospun membrane, and then a heat-shrinkable tube is added to the outermost layer , adjust the temperature of the heat gun to increase the temperature of the heat-shrinkable tube to melt the TPU electrospun membrane, thereby bonding the PTFE membrane to the metal stent, and the shr...

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Abstract

The invention discloses a preparation method of a tubular polytetrafluoroethylene (PTFE) covered stent. The method comprises the following steps of S1, preparing a tubular PTFE / PEO (polyoxyethylene) fiber membrane through an electrostatic spinning method by taking a metal mandrel sleeved with a braided tube as a receiving device; S2, drying the tubular PTFE / PEO fiber membrane, and sintering the tubular PTFE / PEO fiber membrane at 360-400 DEG C for 5-15 minutes; and S3, providing a metal stent, coating the surface of the metal stent with a polyurethane (TPU) adhesive by brushing, then sleeving the metal stent with the tubular PTFE fiber membrane, putting the metal stent into water to remove N,N-dimethylformamide (DMF) and cure the TPU, taking out the metal stent, drying the metal stent, sleeving the tubular PTFE fiber membrane with a heat-shrinkable tube, and performing heating to shrink the tubular PTFE fiber membrane to be more tightly combined with the metal stent, thereby obtaining the tubular PTFE covered stent. The tubular PTFE covered stent has good mechanical properties, water permeability and blood compatibility, the hemolysis rate is lower than 5%, the cell adhesion and proliferation of human umbilical vein endothelial cells (HUVECs) can be supported, and the cytotoxicity is avoided.

Description

technical field [0001] The invention relates to the technical field of vascular stent grafts, in particular to a PTFE tubular stent graft and a preparation method thereof. Background technique [0002] Arterial expansion diseases such as pseudoaneurysm caused by trauma, infection, operation, immune disease, hypertension, atherosclerosis and other reasons seriously threaten human health. If not treated in time, the gradually thinning blood vessel wall or the tumor wall lacking muscular layer and elastic layer are easy to rupture, and the mortality rate is as high as 78%-95%. The traditional treatment of such diseases is open surgery, which has disadvantages such as high risk, large trauma, and complicated operation. With the advancement of material science, engineering technology, and surgical technology, a new type of endovascular isolation of stent grafts has been invented. This technique uses a covered stent to completely isolate the parent artery from the pseudoaneurysm...

Claims

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Application Information

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IPC IPC(8): D04H1/728D04H1/76D01D5/00D06C7/00
CPCD04H1/728D04H1/76D01D5/0084D01D5/003D06C7/00D10B2509/06D06C7/02D04H1/4318D01F6/12D01D5/0038D01D1/02
Inventor 赵荟菁骆宇孟凯张克勤龚霄雁薛志恒刘浩
Owner SUZHOU UNIV
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