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Application of rose odorata var gigantea fruit extract in preparation of medicine, health care product or food for preventing and treating stomach diseases

A technology for the fruit and extract of the fruit of the fruit, applied in the preparation of drugs for the prevention and/or treatment of gastric diseases, the fruit extract of the fruit of the fruit, the health care product or the food field, which can solve the problem that the fruit extract of the fruit of the fruit has not been seen effectiveness research and other issues

Pending Publication Date: 2021-08-13
应远达(大连)技术咨询有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, there are few studies on this fruit, only clarified that it is rich in SOD and triterpenoids, and related reports on the development of fruit wine with the fruit of Gugongguo as raw materials (the quality standard of Changshu Tablets, National Drug Administration Bureau's 2002-2004 trial standard), but so far there has been no research on the efficacy of the fruit extract of G.

Method used

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  • Application of rose odorata var gigantea fruit extract in preparation of medicine, health care product or food for preventing and treating stomach diseases
  • Application of rose odorata var gigantea fruit extract in preparation of medicine, health care product or food for preventing and treating stomach diseases
  • Application of rose odorata var gigantea fruit extract in preparation of medicine, health care product or food for preventing and treating stomach diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Embodiment 1 tannin content determination

[0030]Instrument: Shimadzu 1601 spectrophotometer; HZQ-QX electric oscillator (Donglian Electronic Technology Development Co., Ltd.)

[0031] Standards and reagents: gallic acid reference substance (content 98%); casein (chemically pure); sodium carbonate; sodium tungstate; sodium molybdate; lithium sulfate (the above reagents are of analytical grade).

[0032] Preparation of phosphomolybdenum tungstic acid reagent: Take 100g of sodium tungstate, 25g of sodium molybdate, add 700mL of water to dissolve, add 100mL of hydrochloric acid, 50mL of phosphoric acid, heat to reflux for 10h, let cool, add 150g of lithium sulfate, 50mL of water and 0.2mL of bromine , boil to remove residual bromine (about 15min), cool, add water to dilute to 1000mL, filter, that is.

[0033] Drawing of standard curve of casein method:

[0034] Preparation of reference solution

[0035] Accurately weigh 0.050g of gallic acid standard substance, place i...

Embodiment 2

[0043] The determination of total triterpene content of embodiment 2

[0044] Test materials: Anhydrous ethanol, 95% ethanol, glacial acetic acid, perchloric acid, vanillin, concentrated sulfuric acid, etc. are all analytical reagents; ursolic acid standard reference substance (China Institute for the Control of Pharmaceutical and Biological Products); UV-1601 UV-visible Spectrophotometer (Shimadzu Corporation, Japan).

[0045] Test methods: (1) Determination of the optimal detection wavelength of the ursolic acid reference substance and drawing of the standard curve.

[0046] Accurately weigh 4.0 mg of ursolic acid reference substance that has been baked to constant weight, add absolute ethanol to dissolve it, and dilute to 50 mL, with a mass concentration of 0.08 mg / mL. Take a certain amount of ursolic acid reference solution in a 10mL test tube, add 0.2ml of newly prepared vanillin-5% glacial acetic acid and 0.8ml of perchloric acid, heat in a water bath at 60°C for 15min,...

Embodiment 3

[0050] The preparation of embodiment 3 Gugongguo fruit extract

[0051] Take 500g of Gugongguo fruit as raw material, add it into 50% ethanol aqueous solution with a mass ratio of 1:6, reflux extraction for 1 hour, extract 3 times, and pass through a 80-120 mesh sieve to obtain the extract; collect the extract, Concentrate under reduced pressure at a temperature of 60° C. and a vacuum of 0.06 to 0.08 MPa to obtain a concentrate with a sugar content of 10, which is then dried to obtain the fruit extract of Gugongguo with an extraction rate of 13.5%. Wherein the tannin content is 34%, and the total triterpene content is 10.4%.

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Abstract

The invention provides an application of a rose odorata var gigantea fruit extract in preparation of medicine, health care product or food for treating and / or preventing stomach diseases. Experiments prove that the rose odorata var gigantea fruit extract has the effects of treating atrophic gastritis and repairing gastric mucosal lesion, and the curative effect is exact. The invention discloses a new application of the medicinal material rose odorata var gigantea fruit.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicines, and in particular relates to the use of Ggongguo fruit extracts in the preparation of medicines, health care products or food for preventing and / or treating stomach diseases. Background technique [0002] Gastric diseases refer to organic or functional diseases that occur in the stomach. Clinically common chronic gastritis, peptic ulcer and gastric cancer. The etiology of stomach diseases is very complex, including physical and chemical stimulation, infection, toxin, heredity, mental factors, developmental disorders, and surgical effects. Gastritis refers to inflammation of the gastric mucosa caused by various reasons, and is one of the most common digestive system diseases. According to the priority of clinical onset, it can generally be divided into two types: acute and chronic gastritis; according to different etiologies, it can be divided into Helicobacter pylori-associated gast...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/73A61P1/04A61P35/00A23L33/105A61K131/00
CPCA61K36/73A61P1/04A61P35/00A23L33/105A23V2002/00A61K2236/33A61K2236/333A61K2236/39A61K2236/51A23V2200/32A23V2200/30A23V2200/308A23V2250/21
Inventor 刘岱琳张静泽全帅韩恰恰李新宇赵艳敏
Owner 应远达(大连)技术咨询有限公司
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