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Microcapsule, preparation method thereof and application of microcapsule in prevention and/or treatment of salivary gland injury caused by radiotherapy

A solution and vitamin technology, applied in the field of pharmaceutical preparations and medicine, can solve problems such as no effective treatment drugs

Active Publication Date: 2021-09-17
BEIJING STOMATOLOGY HOSPITAL CAPITAL MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, at present, there is no effective drug for the treatment of salivary gland damage caused by radiation therapy.

Method used

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  • Microcapsule, preparation method thereof and application of microcapsule in prevention and/or treatment of salivary gland injury caused by radiotherapy
  • Microcapsule, preparation method thereof and application of microcapsule in prevention and/or treatment of salivary gland injury caused by radiotherapy
  • Microcapsule, preparation method thereof and application of microcapsule in prevention and/or treatment of salivary gland injury caused by radiotherapy

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0059] Embodiment 1 A kind of microcapsule preparation of vitamin C and nitrate

[0060] 1.1 Reagents and instruments

[0061] Pectin, sodium carboxymethylcellulose (CMC-Na), Nantong Tailida New Material Co., Ltd.; chitosan (chitosan 3000, chitosan 75000), Anhui Yuanzheng Bioengineering Co., Ltd.; vitamin C, sodium nitrate , Merck Reagent Company (sigma-aldrich); sodium heptanesulfonate, vitamin standard, Shanghai Yuanye Company; EDTA, isopropanol, triethylamine, glacial acetic acid, ethanol, Beijing Reagent Company.

[0062] Electronic balance BSA124, Sartorius Instrument Co., Ltd.; rotary evaporator LABOROTA4003, German Heidolf Instrument Co., Ltd.; 101-0 electric heating constant temperature blast drying oven, Tianjin Tester Instrument Co., Ltd.; magnetic stirrer, ultrafine pulverizer, IKA Instrument Co., Ltd., Germany; ultrafine powder jet mill: model: R&D Jet Mills Lab; KQ-500DE CNC ultrasonic cleaner, Kunshan Ultrasonic Instrument Co., Ltd.; vacuum freeze dryer Alpha1-4...

Embodiment 2

[0131] The pharmacokinetic test of the microcapsule of embodiment 2 embodiment 1

[0132] This example studies the sustained-release kinetic properties of the microcapsules prepared in Example 1.

[0133] 1. In vitro test

[0134] Preparation of simulated gastric juice: Take 3.2 g of pepsin and 2 g of sodium chloride, add 7 mL of hydrochloric acid and water to dissolve to 1000 mL, and the pH value of the solution is 1.2.

[0135] Preparation of simulated intestinal juice: Take 6.8 g of potassium dihydrogen phosphate, add 250 mL of water to dissolve, add 77 mL of 0.2 mL / L sodium hydroxide solution and 500 mL of water, add 10 g of trypsin to dissolve, then use sodium hydroxide solution or Adjust the pH to 6.8 with 0.2mol / L hydrochloric acid solution, and then dilute to 1000 mL with water.

[0136] Method: Accurately weigh 50 mg of microcapsules, place them in a reagent bottle, then add 100 mL of simulated intestinal juice or simulated gastric juice, place the reagent bottle on...

Embodiment 3

[0143] Embodiment 3 In vitro cell experiment of the microcapsule of the present invention

[0144] In this example, by testing the proliferation of human submandibular gland epithelial cell line (HSG) (purchased from ATCC cell bank) loaded with different drugs after radiation, the effect of microcapsules of the present invention (microcapsules prepared according to the method described in Example 1) on Protection of human submandibular gland epithelial cells after radiation.

[0145] 2.1 Effects on cell proliferation:

[0146] 1) Cells were plated into RTCA (RTCA S16, Agilent) cell proliferation assay plate, 1×10 per well 4 cells, 4 hours after plating, when the cells were attached to the wall and in the logarithmic growth phase, 10 μL of different drugs (sodium nitrate 0.5 mM, microcapsules of Example 1 0.25 mM, V C 60.325 μM, and the control group was normal saline), the changes in cell proliferation were detected continuously, and the results are shown in Table 4.

[01...

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Abstract

The invention provides a microcapsule of vitamin C and nitrate. The microcapsule comprises a wall material and a core material encapsulated in the wall material, wherein the wall material comprises pectin and sodium carboxymethyl cellulose, and the core material comprises the vitamin C, the nitrate and chitosan; and the microcapsule comprises the following raw materials of, in parts by weight, 0.7-1.2 parts by weight of the pectin, 0.7-1.2 parts by weight of the sodium carboxymethyl cellulose, 1 part by weight of the chitosan, and 0.3-1.2 parts by weight of the vitamin C and the nitrate in total, wherein the molar ratio of the vitamin C to the nitrate ions is 1 to 1-1 to 5. The invention further provides application of the microcapsule in a medicine for preventing and / or treating salivary gland injury caused by radiotherapy, especially application in preparation of a medicine for preventing and / or treating salivary gland injury caused by nasopharyngeal carcinoma radiotherapy.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparation and medicine, and in particular relates to a microcapsule and its preparation method and application. Background technique [0002] Microencapsulation technology refers to the technology of embedding and sealing solid, liquid or gas in a tiny, airtight capsule to become a solid particle product. Generally, the encapsulated object is called the core material, and the encapsulated object is called the wall material. Through microencapsulation, it is possible to protect substances from the environment, mask unpleasant taste or odor, change the state of existence, mass or volume of substances, reduce toxicity, and control release. [0003] Combinations of vitamin C and nitrates have been shown to have antineoplastic activity. However, the nature of vitamin C is very unstable, and environmental factors such as temperature, pH value, oxygen, metal ions, ultraviolet rays and X-rays will affect...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/52A61K33/00A61K31/375A61K47/38A61P1/02
CPCA61K9/5042A61K33/00A61K31/375A61P1/02A61K2300/00
Inventor 王松灵王玉记李文斌冯晓宇潘雯吴志芳周建
Owner BEIJING STOMATOLOGY HOSPITAL CAPITAL MEDICAL UNIV
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