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Preparation method and application of antibacterial polymer nanoparticles based on PISA

A nanoparticle and macromolecule technology is applied in the field of preparation of antibacterial macromolecular nanoparticles to achieve the effects of simple and rapid preparation process, overcoming compatibility and inhibiting bacterial growth.

Active Publication Date: 2021-09-28
HUBEI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, how to more easily and effectively prepare quaternary ammonium salt polymers with different forms and different wettability, and further functionalize and modify them to improve the durability of antibacterial effect is still a problem.

Method used

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  • Preparation method and application of antibacterial polymer nanoparticles based on PISA
  • Preparation method and application of antibacterial polymer nanoparticles based on PISA
  • Preparation method and application of antibacterial polymer nanoparticles based on PISA

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] 1. Preparation of block copolymer pDMAEMAsalt-b-p (St-co-TFEMA)

[0033] The synthetic scheme of described pDMAEMAsalt-b-p (St-co-TFEMA) is:

[0034]

[0035] The schematic diagram of the synthesis scheme is as figure 1 Shown, preparation method is specifically as follows:

[0036] (1) Preparation of macromolecular RAFT chain transfer agent pDMAEMA-CTA

[0037] A certain amount of monomer dimethylaminoethyl methacrylate (DMAEMA), chain transfer agent 2-cyano-2-propylbenzodisulfide (CPDB) and initiator Azobisisobutyronitrile (AIBN) and solvent 1,4-dioxane, fully stirred and mixed evenly, then sealed. Place in an ice-water bath, pass high-purity nitrogen gas to remove oxygen for 40 minutes, and transfer the reaction system as a whole to a 65°C oil bath for reaction. After the desired effect is achieved, open the mouth and expose to the air to terminate the reaction.

[0038] The reactant was purified by dissolving in acetone / precipitating in n-hexane three times, a...

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PUM

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Abstract

The invention discloses a preparation method of antibacterial polymer nanoparticles based on PISA, wherein the method comprises the steps: taking DMAEMA as a monomer, reacting under the action of a chain transfer agent CPDB and an azo initiator, and then adding 1-bromobutane to continuously react to prepare a solvent-philic macromolecular RAFT chain transfer agent pDMAEMA salt-CTA; and mixing St and TFEMA, adding the mixture into a pDMAEMA salt-CTA aqueous solution, adding an azo initiator, sealing to remove oxygen, reacting at the temperature of 60-70 DEG C, and cooling to obtain the polymer nanoparticles pDMAEMA salt-b-p (St-co-TFEMA). The RAFT-PISA technology is adopted, the block polymer nanoparticles pDMAEMA salt-b-p (St-co-TFEMA) are prepared in a soap-free emulsion polymerization system through a one-step method with high solid content, the high specific surface area of the block polymer nanoparticles can be used as an effective carrier of a quaternary amine chain segment, negatively charged bacteria are adsorbed through electrostatic interaction, and cell walls are collapsed so as to inhibit growth of bacteria; and meanwhile, due to introduction of a hydrophobic chain segment, the cytotoxicity can be reduced while the antibacterial performance is maintained. The invention provides a high polymer material and a preparation method thereof, wherein the high polymer material is simple to operate and low in cost and has double functions of adhesion resistance and sterilization.

Description

technical field [0001] The invention belongs to the technical field of antibacterial polymer materials, and in particular relates to a preparation method and application of antibacterial polymer nanoparticles based on PISA. Background technique [0002] Pathogenic bacteria are a major threat to public health. Bacteria attached to the surface of materials will form biofilms that are difficult to remove, and the abuse of antibiotics will lead to enhanced drug resistance of single-cell pathogens. Traditional organic polymer bactericidal materials are widely used due to their high-efficiency bactericidal properties and low biological toxicity, but a single bactericide will damage the surface due to the continuous consumption of bactericidal particles and bacterial biofilm residues due to its bactericidal mechanism. And it has poor stability and durability, and a single anti-adhesion surface is often inferior to contact sterilization materials in antibacterial performance. Highl...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F293/00A01N33/12A01N37/36A01P1/00
CPCC08F293/005A01N33/12A01N37/36C08F2438/03Y02A50/30
Inventor 杨婷婷张壹霖杨思行高庆
Owner HUBEI UNIV