Porous composite bone cement and preparation method thereof

A bone cement and dehydrating agent technology, applied in surgical adhesives, prostheses, surgery, etc., can solve problems such as low interface bonding force, inability of bone cells to grow in, affect the mechanical properties and biocompatibility of bone cement, and achieve Good biocompatibility, good biocompatibility and effect of biodegradability, non-immunogenic biocompatibility

Active Publication Date: 2021-11-02
山东明德生物医学工程有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to provide a porous composite bone cement and its preparation method, which overcomes the above-mentioned deficiencies in the prior art, can be used in orthopedics, osteoporotic fracture fixation, bone defect filling, etc., and solves the problem of traditional bone cement and autologous bone cement. Low interfacial bonding between bones, inability of bone cells to grow in, and the residual reactants of porogen after the current porous bone cement is cured affect the mechanical properties and biocompatibility of bone cement

Method used

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  • Porous composite bone cement and preparation method thereof
  • Porous composite bone cement and preparation method thereof
  • Porous composite bone cement and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0024] A porous composite bone cement, mainly composed of 20g powder and 10mL liquid, the powder mainly consists of the following raw materials: PMMA 11.98g, degradable biomaterial 2g, barium sulfate 6g, benzoyl peroxide 0.02g , the above raw materials were mixed uniformly to obtain bone cement powder; the liquid mainly consisted of the following raw materials: methyl methacrylate 9.45ml, N,N-dimethyl-p-toluidine 0.5mL, hydroquinone 0.05mL, the above raw materials Mix to obtain a bone cement liquid.

[0025] The degradable biomaterial is a copolymer with three branched chain structures mainly obtained by polymerization of polyethylene glycol and citric acid through esterification reaction. The specific preparation method is: EDCI, DMAP, citric acid, polyethylene glycol (Molecular weight is 200) mixed according to the molar ratio of 2:0.5:1:3, dissolved in n-butanol solvent, reacted at 40°C for 6h, separated after the reaction, and dried in vacuum.

[0026] The preparation met...

Embodiment 2

[0028] A porous composite bone cement, mainly composed of 20g powder and 10mL liquid. The powder is mainly composed of the following raw materials: PMMA 10.98g, degradable biomaterial 3g, barium sulfate 6g, benzoyl peroxide 0.02g , the above raw materials were mixed uniformly to obtain bone cement powder; the liquid mainly consisted of the following raw materials: methyl methacrylate 9.3ml, N,N-dimethyl-p-toluidine 0.5mL, hydroquinone 0.2mL, the above raw materials Mix to obtain a bone cement liquid.

[0029] The degradable biomaterial is a copolymer with three branched chain structures mainly obtained by polymerization of polyethylene glycol and citric acid through esterification reaction. The specific preparation method is: N, N-dicyclohexylcarbodiimide , tetrabutyl titanate, citric acid, and polyethylene glycol (molecular weight: 400) were mixed according to the molar ratio of 2:0.5:1:3, and dissolved in n-butanol solvent, and reacted at 40°C for 5h, and carried out after t...

Embodiment 3

[0032] A porous composite bone cement, mainly composed of 20g powder and 10mL liquid. The powder is mainly composed of the following raw materials: PMMA9.98g, degradable biomaterial 4g, barium sulfate 6g, benzoyl peroxide 0.02g , the above raw materials were mixed uniformly to obtain bone cement powder; the liquid mainly consisted of the following raw materials: methyl methacrylate 9.945ml, N,N-dimethyl-p-toluidine 0.05mL, hydroquinone 0.005mL, the above raw materials Mix to obtain a bone cement liquid.

[0033] The degradable biomaterial is a copolymer with three branched chain structures mainly obtained by polymerization of polyethylene glycol and citric acid through esterification reaction. The specific preparation method is: EDCI, tetraisopropyl titanate, citric acid and polyethylene glycol (molecular weight: 600) were mixed according to the molar ratio of 2:0.5:1:3, dissolved in n-butanol solvent, reacted at 40°C for 8 hours, separated after the reaction, and dried in vac...

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Abstract

The invention relates to the technical field of biomedical materials, in particular to porous composite bone cement and a preparation method thereof. The porous composite bone cement is mainly composed of a powder part and a liquid part, the ratio of the powder part to the liquid part is 2: 1 g/mL. The powder part is mainly composed of the following raw materials in percentage by mass: 29.5-84% of a methacrylic acid polymer, 10-40% of a degradable biological material, 5-30% of barium sulfate and 0.01-0.5% of benzoyl peroxide; the liquid is mainly prepared from the following raw materials in percentage by mass: 93-99.45% of methyl methacrylate, 0.5-5% of N, N-dimethyl p-toluidine and 0.05-2% of hydroquinone. The problems that the interface bonding force between traditional bone cement and autologous bone is low, bone cells cannot grow into the bone cement, and the mechanical property and biocompatibility of the bone cement are affected by reactants left in a pore-foaming agent after the existing porous bone cement is cured are solved.

Description

technical field [0001] The invention relates to the technical field of biomedical materials, in particular to a porous composite bone cement and a preparation method thereof. Background technique [0002] Bone cement is the common name for bone cement, a medical material used in orthopedic surgery. PMMA bone cement is an injectable filling and bonding material that was first used in prosthetic replacement surgery. At present, it has been widely used in orthopedic clinics, especially in spinal repair and shaping. [0003] PMMA bone cement has many advantages as a filling material in orthopedic surgery: good injectability; good viscosity, good adhesion to bone and implant equipment; excellent mechanical strength; fast curing time Wait. Simultaneously, PMMA bone cement is used as the injection material for human body, and its deficiency is also obvious. PMMA bone cement is a synthetic polymer. This material has poor compatibility with bone and cannot form a good combination...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L24/04A61L24/06A61L24/00A61L27/56A61L27/50A61L27/18A61L27/16C08G65/332
CPCA61L24/046A61L24/06A61L24/0036A61L24/001A61L27/56A61L27/50A61L27/18A61L27/16C08G65/3322A61L2430/02C08L71/02C08L33/12
Inventor 李朝阳李梦霞崔永顺吕维加
Owner 山东明德生物医学工程有限公司
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