Multifunctional coating applicable to urinary medical apparatus and preparation method and application thereof

Abstract

The invention provides a multifunctional coating suitable for urinary medical instruments. The multifunctional coating is prepared from a bio-based anionic polymer and organosilicon quaternary ammonium salt. The invention further provides a preparation method of the multifunctional coating. The invention further provides the compound suitable for the urinary medical apparatus and instruments. The multifunctional coating provided by the invention has relatively good antibacterial performance, protein adhesion performance, bactericidal performance and anti-crusting performance.

Description

technical field [0001] The invention relates to the technical field of medical devices, in particular to a multifunctional coating suitable for urinary medical devices, its preparation method and application. Background technique [0002] Bacterial infection and crust formation are common complications during the implantation / intervention of urological medical devices. UTIs are the most common nosocomial infection after respiratory and bloodstream infections. Catheter-related urinary tract infections have been reported in up to 98% of intensive care unit urinary tract infections. When urinary medical devices are implanted in the body as a foreign body, a layer of urine conditioning film will be rapidly formed on the surface, including lipids, proteins, inorganic salts, etc. stone. When bacteria exist, bacterial metabolites such as polysaccharides and mucins can form biofilms, which can coagulate and support uroliths, and can become the core of uroliths, especially urease-...

AI Technical Summary

Problems solved by technology

Bacterial infection and crust formation are complementary and mutually causal, and together cause serious consequences such as urinary tract blockage, tissue necrosis, and sepsis, which seriously threaten the lives of patients and bring huge challenges to the entire medical field

[0003] In order to solve the bacterial infection and incrustation complications caused by urinary medical devices, researchers have proposed many strategies, mainly including: (1) Anti-adhesion coatings for metabolic stones and infectious stones caused by non-urease-positive bacteria, including Hydrophilic surfaces based on hyaluronic acid, phosphorylcholine, chondroitin sulfate, etc. and superhydrophobic surfaces formed by designing micro-nano structures can inhibit the adhesion and formation of bacteria and metabolic crusts in a short period of time, but once bacteria exist Or if bacteria adhere, such surfaces will quickly fail (such as publication number CN110477982A); (2) For infectious stones, build a sterilizing surface to kill bacteria and inhibit the formation of stones, including silver, antibiotics and other drug-eluting release type sterilization The antimicrobial agent is immobilized on the surface or through strategies such as surface grafting to construct a contact-type bactericidal surface, but the release-type bactericidal surface faces limitations such as easy drug resistance and poor biocompatibility (such as the literature ACS Nano, 2009, 3, 279)

Constructing an anti-killing binding surface to achieve anti-bacteria, stone adhesion and bactericidal properties is also a common method, but this construction method is generally complicated, involving multi-step processing, and it is difficult to modify the catheter lumen, so the applicability is poor

In addition, there are few or no related reports to construct and explore the effect of functional surfaces on both metabolic stones and infectious stones.

Images