Application of GMFB as insulin resistance biomarker

Abstract

The invention relates to the technical field of treatment of insulin resistance, and in particular relates to application of a cytokine GMFB, and application of the GMFB as a biomarker of insulin resistance. Experiments discover that GMFB as an inflammatory factor is high in expression in an insulin resistance state caused by high fat diet and is not expressed or extremely low in expression in a normal condition, which indicates that GMFB plays a role in adipose tissues in the insulin resistance state and can inhibit the functions of the adipose tissues. The plasma insulin concentration of a high-fat diet rat after GMFB gene knockout is obviously reduced compared with that of a wild type high-fat diet rat, which indicates that the GMFB gene knockout can improve insulin resistance caused by high-fat diet; GMFB gene knockout obviously improves the glucose tolerance of SD rats; the insulin tolerance is improved; the functions of fat cells are improved.

Description

technical field

[0001] The invention relates to the field of insulin resistance treatment, in particular to the use of a cytokine GMFB, and the application of GMFB as a biomarker of insulin resistance. Background technique

[0002] With the development of society, the improvement of living standards, and the change of lifestyle, dietary structure has changed significantly, and the number of obese people has also increased sharply. With the rising rate of obesity, type 2 diabetes is on the rise globally, and has become the third chronic non-communicable disease that threatens human health after cancer and cardiovascular disease. Type II diabetes has a high prevalence rate and long course of disease, and is often accompanied by serious complications, such as diabetic nephropathy, diabetic cardiovascular disease and retinopathy, which not only seriously affect the quality of life of patients, but also bring great harm to patients' families and society. Therefore, the preventio...

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