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Sulfonated polyetheretherketone-based bone repair composite material

A technology of sulfonated polyetheretherketone and composite materials, which is applied in the fields of organic chemistry, chemical instruments and methods, carrier binding/immobilization of peptides, etc. The effect of promoting bone marrow mesenchymal stem cell adhesion, good biocompatibility, and simple synthesis and preparation

Active Publication Date: 2021-12-10
GUANGDONG UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These two modification methods provide a certain promotion for the application of polyetheretherketone (PEEK) in the field of tissue engineering scaffolds, but the simple surface chemical modification and coating modification have a single physiological effect on the body and cannot achieve multiple Unified performance

Method used

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  • Sulfonated polyetheretherketone-based bone repair composite material
  • Sulfonated polyetheretherketone-based bone repair composite material
  • Sulfonated polyetheretherketone-based bone repair composite material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] (1) Polish one side of a cylindrical polyether ether ketone (PEEK) with a diameter of 10 mm and a thickness of 1 mm to a mirror smoothness, use acetone, absolute ethanol and deionized water to ultrasonically clean 3 times for 15 minutes each time, and then Dry for 24 hours to obtain spare polyetheretherketone (PEEK); in a ventilated table, polyetheretherketone (PEEK) is subjected to 18.4mol / L concentrated sulfuric acid rotary sulfonation treatment for 40s, and then washed with ultrapure water to remove residual concentrated sulfuric acid and water. Thermal treatment to remove sulfur (hydrothermal condition: 120°C, 4h), in N 2 Sulfonated polyether ether ketone (S-PEEK) was obtained after drying in the air stream for 24 hours.

[0050] (2) Weigh 33.62g EDTANa 2 (ethylenediaminetetraacetic acid disodium salt), dissolved in 2000ml ultrapure water, stirred to make 0.05M / L EDTANa 2 Solution, add NaOH solid particles while stirring, after the solution is clarified, stop addi...

Embodiment 2

[0073] Same as Example 1, the difference is that step (1) preparation process of sulfonated polyetheretherketone is omitted.

[0074] The results show that there is no 3D network structure on the surface of the material. Although the surface structure is polished by sandpaper, the surface is still relatively rough and has many scratches on the surface. It is generally believed that the 3D network structure is conducive to cell adhesion due to its increased surface roughness and enhanced hydrophilicity. Sulfonated polyetheretherketone material of nanoprotein.

Embodiment 3

[0076] The same as Example 1, the difference is that the hydrothermal treatment step in the preparation process of step (1) sulfonated polyetheretherketone is omitted.

[0077] The results showed that most of the bone marrow mesenchymal stem cells in SD rats died without the ability of attachment, proliferation and differentiation.

[0078] The purpose of the hydrothermal treatment step is twofold, first: remove residual concentrated sulfuric acid (because the existence of residual concentrated sulfuric acid is not conducive to cell attachment, proliferation, and differentiation); second: hydrothermal treatment can stabilize sulfonated polyether ether The 3D network structure on the surface of the ketone can reduce the adverse effects on cell attachment, proliferation and differentiation caused by the instability of the 3D network structure in later experiments.

[0079] If there is no hydrothermal treatment step, the residual sulfuric acid in the sulfonated PEEK material will...

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Abstract

The invention belongs to the medical field of biological tissue engineering, and particularly relates to a sulfonated polyetheretherketone-based bone repair composite material. The sulfonated polyetheretherketone-based bone repair composite material takes sulfonated polyetheretherketone as a carrier, and nano protein is loaded on the surface of the sulfonated polyetheretherketone-based bone repair composite material. The preparation method comprises the following steps: sulfonating polyether-ether-ketone with an acid solution, washing, carrying out water thermalization, and drying to obtain sulfonated polyether-ether-ketone; and dropwise adding the nano protein solution to the surface of the sulfonated polyether-ether-ketone, freeze-drying, freeze-drying, and disinfecting to obtain the sulfonated polyether-ether-ketone-based bone repair composite material. The product provided by the invention has good biocompatibility, can promote adhesion, proliferation and differentiation of SD rat bone marrow mesenchymal stem cells through test verification, also has excellent properties of oxidative stress resistance, antibacterial property and the like, and has the advantages of easily available raw materials, simple synthesis and preparation, simple and convenient process, high preparation efficiency and realization of large-scale production.

Description

technical field [0001] The invention belongs to the medical field of biological tissue engineering, and more specifically relates to a sulfonated polyetheretherketone-based bone repair composite material. Background technique [0002] Polyetheretherketone (PEEK) is a semi-crystalline polymer with a degree of crystallinity typically between 30%. Polyetheretherketone (PEEK) has excellent properties such as non-toxicity, high melting temperature (Tm=340°C), high glass transition temperature (Tg=143°C), chemical corrosion resistance, and wear resistance. Polyetheretherketone (PEEK) was first introduced into the medical field in the early 1990s. It has many excellent properties. The elastic modulus of polyetheretherketone (PEEK) is between 3-4GPa, which is close to the elastic modulus of cortical bone (~ 18GPa), it can have a good docking with human bone, so it can be used as a human hard tissue implant material. Polyetheretherketone (PEEK) is well-formed and can be processed b...

Claims

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Application Information

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IPC IPC(8): A61L27/18A61L27/34A61L27/54A61L27/56C07K17/08C07K1/34
CPCA61L27/18A61L27/34A61L27/54A61L27/56C07K17/08C07K1/34A61L2430/02A61L2300/252A61L2300/40C08L61/16C08L89/00
Inventor 李达闵永刚刘胜东刘屹东
Owner GUANGDONG UNIV OF TECH
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