Human milk oligosaccharides for use in enhancing executive function

A human milk oligosaccharide and executive function technology, applied in the field of HMO or compositions containing HMO, can solve the problems of lower patient compliance, limited, poor children's effect, etc.

Pending Publication Date: 2021-12-21
GLYCOM AS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, CBT is less effective in children
In addition, effective drugs are not always available for the diagnosed disease, or the drugs have serious side effects, which can reduce patient compliance
Furthermore, there are extremely limited avenues to prevent executive function problems or disorders in at-risk non-infant humans

Method used

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  • Human milk oligosaccharides for use in enhancing executive function
  • Human milk oligosaccharides for use in enhancing executive function
  • Human milk oligosaccharides for use in enhancing executive function

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0143] Methods - Behavioral Research

[0144] Fifty-three female piglets (Ellegaard Göttingen minipigs, Denmark) were subjected to the orifice plate test after weaning. At 1 week of age, formula-fed (N = 45) piglets were separated from sows and housed in mixed groups of 2 piglets in bedding enriched with crushed straw with squeeze balls and dog beds In the fence (2.5m×1m). In addition, 8 piglets were cross-reared and kept with 3 sows until 10 weeks of age (natural suckling piglets). After weaning from breast milk, at 10 weeks of age, naturally suckled piglets were housed under the same conditions as formula-fed piglets. Two metal chains were also added to the pen as additional enrichment material.

[0145] Treatment. The time of milk intervention is from 1 week to 10 weeks. At 1 week of age, formula-fed piglets were randomly assigned to 1 of 4 milk formulas enriched with different prebiotic mixtures (milk A: 3'-SL and 6'-SL, milk B : 2'-FL+DFL+LNT+LNnT, milk C: 2'-FL+DFL+...

Embodiment 2

[0155] Animals and Housing Conditions

[0156] Adult wild-type (WT) B6.129 and heterozygous (HZ) B6.129-St6gal1 tm2Jxm Breeding pairs (four males and four females and three males and four females, respectively) were purchased from a commercial breeder (The Jackson Laboratory). Upon arrival, same-sex mice were housed in 2–3 same-sex groups in type 1 polycarbonate cages (33.0 × 13.0 × 14.0 cm), equipped with sawdust pads, enrichment bags (Mucedola, Settimo Milanese, Italy), metal Top and optional water and food pellets (Mucedola, Settimo Milanese, Italy). Mice were maintained on a reversed 12-h light-dark cycle (lights on at 7:00 pm) in an air-conditioned room (temperature 21±1°C and relative humidity 60±10%). Two weeks after arrival, groups of three mice (one male, two females) were formed. Two weeks after mating, male mice were removed and females were housed individually in standard Type 1 cages. Females were checked daily for the time of delivery and the day they gave bi...

Embodiment 3

[0175] Example 3 - nutritional composition

[0176] The ready-to-eat nutritional composition was prepared from the following: water, maltodextrin, corn syrup, sugar, milk protein concentrate, vegetable oils (canola, high oleic sunflower, and corn), soy protein isolate, gum arabic, flavoring, 2 '-FL and DFL, potassium citrate, magnesium phosphate, cellulose gel and gum, calcium carbonate, sodium ascorbate, soy lecithin, choline bitartrate, calcium phosphate, alpha-tocopheryl acetate, ascorbic acid, carrageen Gum, Iron Pyrophosphate, Flavor, Sweetener (Stevia), Vitamin A Palmitate, Niacinamide, Vitamin D3, Calcium Pantothenate, Manganese Sulfate, Copper Sulfate, Pyridoxine Hydrochloride, Thiamine Hydrochloride, Beta Carotene , Riboflavin, Chromium Chloride, Folic Acid, Biotin, Potassium Iodide, Phytomenadione, Sodium Selenite, Sodium Molybdate, Vitamin B12.

[0177] The composition provides a nutritional supplement that is a good source of protein, low fat, vitamins, minerals...

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PUM

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Abstract

The invention discloses use of a human milk oligosaccharide (HMO), or a nutritional composition comprising a human milk oligosaccharide, to enhance executive function in a non-infant, to prevent and / or reduce the risk of sub-optimal executive function in a non-infant, to manage sub-optimal executive functioning in a non-infant, and / or to improve myelination to mature the pre-frontal cortex region of the brain in a non-infant, as well as synthetic compositions of HMOs and packs comprising at least 14 individual daily doses of an effective amount of at least one HMO for such a use.

Description

technical field [0001] The present invention relates to the use of human milk oligosaccharides (HMOs) or compositions comprising HMOs for enhancing non-infant executive functions. The present invention also relates to a HMO or a composition comprising a HMO for use in the prevention or management of suboptimal executive function in non-infants. Background technique [0002] Executive function is the ability to coordinate and integrate cognitive-perceptual processes related to time and space, determining the subject's ability to identify, evaluate and make choices among various alternative options and strategies. It controls goal-directed behavior and plays a fundamental role in regulating higher-order cognitive processes such as problem solving, reasoning, flexible thinking, and decision-making. It is central to cognitive development and learning (especially new skills) and is strongly linked to social and intellectual / academic success and / or achievement. [0003] In human...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/702A23L29/30A23L33/125A61P25/28
CPCA61K31/702A61P25/28A23L33/125A23L33/40A23V2002/00A61P25/00A23V2200/302A23V2200/322A23V2250/28
Inventor B·麦康奈尔L·K·比格斯奈斯J·豪泽尔N·施奈德
Owner GLYCOM AS
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