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Nickel-free Zr-based bulk amorphous alloy with excellent biocompatibility as well as preparation method and application of nickel-free Zr-based bulk amorphous alloy

A biocompatible, amorphous alloy technology, applied in the field of nickel-free Zr-based bulk amorphous alloy and its preparation, can solve problems such as damage to liver and lung function, decline in animal growth rate and reproductive ability, and carcinogenicity. The effect of low, low elastic modulus, high manufacturability

Pending Publication Date: 2022-02-15
INST OF METAL RESEARCH - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, it has been criticized that most of the currently studied Zr-based amorphous alloys contain elements such as Ni and Y that are considered to be cytotoxic, and long-term implantation may cause physiological effects on the human body: there is evidence that Ni can cause dermatitis, low oral Dose studies have shown that Ni can cause a reduction in growth rate and reproductive capacity in animals
Parenteral administration of Ni complexes through inhalation, intravenous and intramuscular can cause Ni to cause cancer; while most rare earth elements have intraosseous accumulation effects, animal experiments on Y elements have proved that long-term intake of Y elements will damage liver and lung function

Method used

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  • Nickel-free Zr-based bulk amorphous alloy with excellent biocompatibility as well as preparation method and application of nickel-free Zr-based bulk amorphous alloy
  • Nickel-free Zr-based bulk amorphous alloy with excellent biocompatibility as well as preparation method and application of nickel-free Zr-based bulk amorphous alloy
  • Nickel-free Zr-based bulk amorphous alloy with excellent biocompatibility as well as preparation method and application of nickel-free Zr-based bulk amorphous alloy

Examples

Experimental program
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Effect test

Embodiment 1

[0037] This embodiment is copper mold spray casting (Zr 53.6 Al 18.6 co 27.8 ) 0.99 Ag 1 (at.%) Amorphous alloy rod.

[0038] The preparation method of this embodiment is as follows: first, the industrial-grade raw materials Zr, Al, Co, and Ag are prepared according to atomic percentage, and smelted under the protection of argon to obtain a master alloy ingot. In order to ensure the quality, it is necessary to use pure Ti as an oxygen absorber to remove residual oxygen in the furnace, and the alloy ingots are smelted at least four times. Then the alloy ingot was mechanically crushed, and spray casting equipment was used to heat and melt the broken master alloy ingot, and sprayed with argon gas into a copper mold with a diameter of 4mm for cooling (4mm is the maximum forming ability of this component). The spray-casting temperature is 1000°C, and the vacuum before spray-casting is 10 -2 Pa.

[0039] Such as figure 1 As shown, the X-ray diffraction results show that the ...

Embodiment 2

[0042] This embodiment is copper mold spray casting (Zr 53.6 Al 18.6 co 27.8 ) 0.98 Ag 2 (at.%) alloy bar.

[0043] The ingredients and master alloy smelting method of this embodiment are the same as in Example 1. In the casting stage, use spray casting equipment to heat and melt the master alloy fragments, and spray them with argon into a 6mm copper mold for cooling (6mm is maximum forming capacity of the component). Among them, the spray casting heating temperature is 1000°C, and the vacuum degree before spray casting is 10 -2 Pa.

[0044] Such as figure 1 As shown, the X-ray diffraction results show that the 6mm rod provided by this comparative example is a pure amorphous structure. Such as Figure 2-3 As shown, the glass transition temperature T of the amorphous alloy g : 488.3, ​​supercooled liquid region △T: 62.7℃, initial melting temperature T m : 913.1℃, liquidus temperature T l : 973.0°C, T l -T m : 59.9°C.

[0045] Use the same process to spray-cast am...

Embodiment 3

[0046] Figure 7 is the OD value of the activity of MC3T3-E1 cells cultured on the amorphous alloy and TC4 in this embodiment. For MC3T3-E1 cells incubated for 24 hours, the OD value of the amorphous alloy was slightly higher than that of the TC4 alloy. After 48 hours, the difference in OD values ​​between the amorphous alloy and TC4 increases. After 72 hours, the OD value of the amorphous alloy was significantly higher than that of TC4. Therefore, compared with cells cultured on TC4, cells cultured on amorphous alloys have higher survival rate and proliferation ability, showing good biocompatibility. Embodiment 3: the present embodiment is copper mold injection casting (Zr 53.6 Al 18.6 co 27.8 )Ag 3 Alloy bars.

[0047] Example 3:

[0048] This embodiment is copper mold spray casting (Zr 53.6 Al 18.6 co 27.8 ) 0.97 Ag 3 (at.%) alloy bar.

[0049] The ingredients and master alloy smelting method of this embodiment are the same as in Example 1. In the casting stag...

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Abstract

The invention discloses a nickel-free Zr-based bulk amorphous alloy with excellent biocompatibility and a preparation method and application thereof, and belongs to the technical field of amorphous alloy materials. The alloy comprises the following chemical components in percentage by atom: 50.6 to 61 percent of Zr, 15.3 to 22.1 percent of Al, 23.5 to 32 percent of Co and 0.01 to 6 percent of Ag. The alloy does not contain cytotoxic elements such as Y, Ni and the like. After the alloy is prepared into a master alloy ingot through vacuum electric arc melting, the master alloy ingot is prepared into a rod-shaped sample through a vacuum suction casting mold, and the minimum amorphous forming size reaches phi 6 mm. The alloy is excellent in mechanical property and shows good corrosion resistance and biocompatibility, and the biocompatibility is better than that of TC4 titanium alloy. Industrial-grade sponge Zr is used as an alloy raw material, the manufacturing cost is low, the manufacturing capacity is excellent, and the alloy has wide application prospects in the biomedical field.

Description

technical field [0001] The invention relates to the technical field of amorphous alloy materials, in particular to a nickel-free Zr-based bulk amorphous alloy with excellent biocompatibility, a preparation method and application thereof. Background technique [0002] Amorphous alloys, also known as metallic glasses, have a special microstructure of long-range disorder and short-range order. In terms of performance, amorphous alloys have the characteristics of high strength, high elasticity, and high hardness. A major disadvantage of amorphous alloys, however, is their low formability. Its manufacturing process requires the molten alloy liquid to be cooled to room temperature at a very high speed, so as to retain the disordered state of the liquid. When the cooling rate is slightly low, it is possible to crystallize the alloy and cannot form pure amorphous. In addition, the atmosphere of the furnace chamber is also an important factor affecting the manufacture of amorphous...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C22C45/10B22F3/115
CPCC22C45/10B22F3/115B22F3/006
Inventor 付华萌邱张维佳张海峰李正坤朱正旺王爱民李宏张龙张宏伟
Owner INST OF METAL RESEARCH - CHINESE ACAD OF SCI
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