Preparation method and application of titanium tricarbon di-bismuth sulfide nanocomposite

A nano-composite material, bismuth sulfide technology, applied in the field of tumor near-infrared phototherapy, can solve the problems of low sensitivity and specificity, lack of targeting, etc., to prolong separation time, increase ROS generation, and good biocompatibility. and targeted effects

Active Publication Date: 2022-07-29
HARBIN MEDICAL UNIVERSITY
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] The purpose of the present invention is to solve the problem of lack of targeting and low sensitivity and specificity in tumor surgical resection, radiotherapy and chemotherapy methods, and at the same time to explore a kind of nanomaterials that take into account both diagnosis and treatment, high efficiency and safety, for tumor patients Formulate a more individualized and precise diagnosis and treatment plan, and provide the preparation method and application of titanium three carbon two-bismuth sulfide nanocomposites

Method used

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  • Preparation method and application of titanium tricarbon di-bismuth sulfide nanocomposite
  • Preparation method and application of titanium tricarbon di-bismuth sulfide nanocomposite
  • Preparation method and application of titanium tricarbon di-bismuth sulfide nanocomposite

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specific Embodiment approach 1

[0018] Embodiment 1: The preparation method of the titanium tricarbon di-bismuth sulfide nanocomposite material of the present embodiment is carried out according to the following steps:

[0019] First, the titanium trialuminum carbon 2 is etched, and then peeled off after the etching treatment; then the oil-soluble titanium tricarbon bismuth sulfide nanocomposite is prepared by the hydrothermal synthesis reaction using the peeled titanium trialuminum carbon 2 as the substrate. Then, the oil-soluble titanium tricarbon-bismuth sulfide nanocomposite was converted into a water-soluble titanium tricarbon-bismuth sulfide nanocomposite, and finally the water-soluble titanium tricarbon-bismuth sulfide nanocomposite was sequentially subjected to mPEG-2K -NH 2 After coating and TPP modification, titanium tricarbon di-bismuth sulfide nanocomposite was obtained.

specific Embodiment approach 2

[0020] Embodiment 2: The difference between this embodiment and Embodiment 1 is that the specific steps of etching titanium trialuminum carbon two are as follows: adding titanium trialuminum carbon two powder to the HCl-LiF mixed solution, at 35 ~ Magnetic stirring for 48-72 hours at a temperature of 38°C, and then repeated centrifugation and washing with deionized water and anhydrous ethanol until the pH was 6-7, to obtain the etched titanium trialuminum carbon 2, and the quality of the titanium trialuminum carbon two powder was the same as that of the powder. The volume ratio of the HCl-LiF mixed solution is 1 g:5 mL, the concentration of HCl in the HCl-LiF mixed solution is 9 mol / L, and the concentration of LiF is 100 g / L.

[0021] Other steps are the same as in the first embodiment.

specific Embodiment approach 3

[0022] Embodiment 3: The difference between this embodiment and Embodiment 1 or 2 is: the specific steps of peeling off the etched titanium trialuminum carbon 2 are as follows: put the etched titanium trialuminum carbon 2 into the tetrapropylene In the base ammonium hydroxide solution, magnetic stirring at room temperature (23 ~ 25 ℃) for 48 ~ 72h, to obtain the peeled titanium trialuminum carbon two, the quality of the etched titanium tri aluminum carbon two and tetrapropyl ammonium hydroxide The volume ratio of the solution was 1 g:5 mL.

[0023] Other steps are the same as in the first or second embodiment.

[0024] In the second to third embodiments, Ti3Al2C2 is etched and peeled off to obtain Ti3C2 nanosheets, which enhances its electrical conductivity and prolongs the electron-hole effect of the nanocomposite material under near-infrared light irradiation. separation time.

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Abstract

The invention relates to a preparation method and application of a titanium tricarbon di-bismuth sulfide nanocomposite material, and relates to the technical field of tumor near-infrared light therapy. The purpose of the present invention is to solve the problems of lack of targeting, and low sensitivity and specificity in tumor resection, radiotherapy and chemotherapy. Method: firstly carry out etching treatment on titanium trialuminum carbon 2, and then carry out peeling treatment after the etching treatment; then take the peeled titanium trialuminum carbon 2 as a substrate, and prepare oil-soluble titanium tricarbon bismuth sulfide through hydrothermal synthesis reaction nano-composite material, and then the oil-soluble titanium tricarbon-bismuth sulfide nanocomposite material is converted into a water-soluble titanium tricarbon-bismuth sulfide nano-composite material, and finally the water-soluble titanium tricarbon-bismuth sulfide nanocomposite material is successively processed for methylation. Oxypolyethylene glycol amine coating and (3-propylcarboxy)triphenylphosphine bromide modification to obtain titanium tricarbon di-bismuth sulfide nanocomposite. The invention can obtain the preparation method and application of titanium tricarbon di-bismuth sulfide nanocomposite material.

Description

technical field [0001] The invention relates to the technical field of near-infrared light therapy for tumors, in particular to a preparation method and application of a nanocomposite material based on titanium tricarbon 2 for near-infrared light therapy of tumors. Background technique [0002] Cancer is a major disease that threatens public health with high morbidity and mortality. In recent years, there are about 19 million new cancer cases and nearly 10 million deaths worldwide each year. At the same time, the current tumor resection, radiotherapy and chemotherapy methods lack targeting, and the sensitivity and specificity are not high. Therefore, the search for a highly efficient and safe nanomaterial that takes into account both diagnosis and treatment, and the development of a more individualized and precise diagnosis and treatment plan for tumor patients is the current research hotspot of tumor treatment, and also has broad clinical application prospects. [0003] So...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C01G29/00C01B32/921A61K41/00A61K47/24A61P35/00A61K49/04A61K49/22B82Y5/00B82Y30/00B82Y40/00
CPCC01G29/00C01B32/921A61K41/0052A61K41/0057A61K47/24A61P35/00A61K49/04A61K49/22B82Y5/00B82Y30/00B82Y40/00C01P2004/80C01P2004/16C01P2004/20C01P2004/03C01P2004/04C01P2002/72C01P2006/60A61K2300/00
Inventor 温朝辉姜涵文孙京先孙冉刘倩韩旭郭阳卢晓晴孙然然
Owner HARBIN MEDICAL UNIVERSITY
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