Chitosan microemulsion for curcumin transdermal delivery and preparation method thereof
A technology of chitosan and curcumin, applied in the field of biomedical materials, can solve problems affecting drug stability, low bioavailability, strong skin irritation, etc., to reduce skin irritation, high-efficiency skin permeability, and promote skin penetration sexual effect
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Embodiment 1
[0034] 1) Place 0.4ml of epichlorohydrin and 1ml of N,N-dimethyl n-dodecylamine in a water bath, heat up to 50°C, and stir for 2 hours to prepare epoxy long-chain alkyl quaternary ammonium salt;
[0035] 2) Add 5ml of isopropanol into 15ml of deionized water, and stir evenly to obtain an isopropanol solution. Get 1g carboxymethyl chitosan and add in isopropanol solution, stir at room temperature to obtain chitosan solution;
[0036] 3) Slowly add the epoxy long-chain alkyl quaternary ammonium salt prepared in step 1) dropwise into the chitosan solution in step 2), and stir while adding dropwise until the mixture is evenly stirred;
[0037] 4) Dissolve 1.45g of sodium hydroxide in 2ml of deionized water, stir evenly to obtain a sodium hydroxide solution, slowly add the sodium hydroxide solution dropwise to the mixture in step 3), stir while adding, dropwise add After completion, keep the mixture in a water bath at 50°C for 24 hours with stirring, and the product is dialyzed wi...
Embodiment 2
[0043] 1) Place 0.4ml of epichlorohydrin and 1ml of N,N-dimethyl n-octadecylamine in a water bath, heat up to 50°C, and stir for 2 hours to prepare epoxy long-chain alkyl quaternary ammonium salt;
[0044] 2) Take 5ml of isopropanol and add it to 15ml of deionized water, stir evenly to obtain an isopropanol solution, take 1g of carboxymethyl chitosan and add it to the isopropanol solution, stir at room temperature to obtain a chitosan solution;
[0045]3) Slowly add the epoxy long-chain alkyl quaternary ammonium salt prepared in step 1) dropwise into the chitosan solution in step 2), and stir while adding dropwise until the mixture is evenly stirred;
[0046] 4) Dissolve 1.45 g of sodium hydroxide in 2 ml of deionized water, stir evenly to obtain a sodium hydroxide solution, slowly add the sodium hydroxide solution dropwise to the mixture in step 3), and stir while adding dropwise. After the dropwise addition was completed, the mixture was kept stirring in a water bath at 50° ...
Embodiment 3
[0052] 1) Place 0.4ml of epichlorohydrin and 1ml of N,N-dimethyl n-octadecylamine in a water bath, heat up to 50°C, and stir for 2 hours to prepare epoxy long-chain alkyl quaternary ammonium salt;
[0053] 2) Take 5ml of isopropanol and add it to 15ml of deionized water, stir evenly to obtain an isopropanol solution, take 1g of carboxymethyl chitosan and add it to the isopropanol solution, stir at room temperature to obtain a chitosan solution;
[0054] 3) Slowly add the epoxy long-chain alkyl quaternary ammonium salt prepared in step 1) dropwise into the chitosan solution in step 2), and stir while adding dropwise until the mixture is evenly stirred;
[0055] 4) Dissolve 1.45 g of sodium hydroxide in 2 ml of deionized water and stir evenly to obtain a sodium hydroxide solution. The sodium hydroxide solution was slowly added dropwise to the mixture in step 3), stirring while adding dropwise. After the dropwise addition was completed, the mixture was kept stirring in a water b...
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