Application of acylated phloroglucinol derivative in preparation of antibacterial agent

Abstract

The invention discloses a novel application of an acylated phloroglucinol derivative in prevention and treatment of fruit postharvest rot-causing fungi, agricultural plant pathogenic fungi, agricultural bacteria and food-borne pathogenic bacteria, and belongs to the field of bactericides. The twenty acylated phloroglucinol derivatives provided by the invention have the advantages that the twenty acylated phloroglucinol derivatives are used for treating postharvest rot-causing fungi such as botrytis cinerea, penicillium expansum ACCC30898, rhizopus stolonifer CICC 40327, monilinia coerulea ACCC 36263, aspergillus flavus ACCC32601 and the like; various plant pathogenic fungi such as rhizoctonia solani, sclerotinia sclerotiorum, fusarium graminearum, magnaporthe oryzae and phytophthora capsici; agricultural bacteria such as Xanthomonas oryzae pv. Oryzae ACCC 116602, Xanthomonas citri pv. Citri and the like; the compound has obvious bacteriostatic or bactericidal activity on food-borne bacteria such as bacillus cereus BNCC 103930, listeria monocytogenes ATCC 19115, salmonella enteritidis ATCC 14028, escherichia coli O157: H7 ATCC 35150 and the like, and can be developed as a broad-spectrum bactericidal lead compound applied to the agriculture or food industry.

Description

technical field [0001] The invention relates to the antibacterial activity of phloroglucinol derivatives and belongs to the field of fungicides. Background technique [0002] Plants of the genus Hypericum belonging to the family Guttiferae have a history of more than 2,400 years of folk medicine. The ingredients such as naphthalenedanthrone, flavonoids and phloroglucinol contained in it show certain antibacterial, antioxidative, antimalarial, anti-inflammatory and anticancer activities, which has attracted extensive attention of researchers. For example, for the separation of phloroglucinol components and polycyclic polyisopentenyl phloroglucinol, polycyclic polyisopentenyl acylated phloroglucinol, and methyl phloroglucinol with phloroglucinol as the starting point Synthesis of derivatives such as glucinol, etc., activity evaluation found that these derivatives are effective against Cryptococcus, Candida albicans, Methicillin-resistant Staphylococcus aureus, Trichomonas rub...

AI Technical Summary

Problems solved by technology

Decayed grains, fruits and vegetables infected by pathogenic microorganisms have poor sensory quality and reduced nutritional value

In addition, even the parts that appear to be uninfected by the naked eye may seep into some mycotoxins, which may seriously endanger human health after ingestion

[0004] In food processing industries such as meat products and dairy products, Bacillus cereus, Listeria monocytogenes, Escherichia coli O157:H7, Salmonella enteritidis, etc. pose a serious threat to human food safety, and the toxins produced by them can cause food poisoning , seriously endangering human health

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