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Traditional Chinese medicine composition for treating kidney-yang deficiency type constipation, preparation and application

A kidney-yang-deficiency type and composition technology, which is applied in the direction of drug combinations, medical preparations containing active ingredients, and pharmaceutical formulas, can solve the problems of poor patient compliance and unsatisfactory laxative effect, and achieve clear curative effect and effective drug delivery. Rapid and significant effect

Active Publication Date: 2022-04-12
云南省中医医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Western medicine commonly prescribes lactulose, polyethylene glycol electrolyte powder and other oral drugs to laxatives in clinical practice. The clinical effect is mediocre, or Kaisailusai is used to laxative the anus. The laxative effect is not satisfactory in patients with post-constipation, and the patient's compliance is poor

Method used

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  • Traditional Chinese medicine composition for treating kidney-yang deficiency type constipation, preparation and application

Examples

Experimental program
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Effect test

Embodiment 1

[0037] Prescription: Epimedium 30g, Cistanche 15g, Angelica 15g, Morinda officinalis 15g, Hempseed 10g, Baiziren 10g, Achyranthes bidentata 10g, Cimicifuga 10g, Rhubarb 5g, Magnolia officinalis 10g, Rehmannia glutinosa 10g. Put all the medicines in a pot, add water to cover the medicines by 2~3cm, soak for 30 minutes, first boil on high heat, then fry on low heat for 30 minutes, take about 150ml of juice; add appropriate amount of water again, boil on high heat, and fry on low heat for 10 minutes, Take about 150ml of the juice, and combine the broth to obtain a decoction.

Embodiment 2

[0039] Recipe: Epimedium 15g, Cistanche 30g, Angelica 30g, Morinda officinalis 30g, Hempseed 30g, Baiziren 30g, Achyranthes bidentata 30g, Cimicifuga 15g, Rhubarb 30g, Magnolia officinalis 15g, Rehmannia glutinosa 30g. Decoct each herbal flavor of the prescription with water at a weight ratio of 1:6, add water and decoct 1 to 3 times, each time for 30 minutes, and combine the decoction liquid; condense the obtained decoction liquid at 65°C, -0.02~-0.06MPa vacuum degree to thicken Paste, the relative density of the thick paste is 1.35g / ml at 60°C; the thick paste is dried at 65°C under a vacuum of -0.02~-0.06MPa to form a dry paste, the dry paste is crushed and passed through a 100-mesh sieve to obtain a mixed dry paste powder, Add 10g of sucrose and mix well, add an appropriate amount of 75% ethanol, wet granulate, and obtain granules after drying.

Embodiment 3

[0041] Prescription: Epimedium 20g, Cistanche 25g, Angelica 20g, Morinda officinalis 25g, Hempseed 15g, Baiziren 20g, Achyranthes bidentata 25g, Cimicifuga 10g, Rhubarb 15g, Magnolia officinalis 10g, Rehmannia glutinosa 20g. Weigh each medicinal herb in the formula according to the formula, add water to decoct 1 to 3 times according to the weight ratio of medicine to water 1:9, each time for 45 minutes, and combine the decoction; Concentrate into a thick paste under vacuum of -0.06MPa, and the relative density of the thick paste is 1.20g / ml at 50°C; dry the thick paste at 75°C under a vacuum of -0.02~-0.06MPa to form a dry paste, crush the dry paste and pass Sieve through a 100-mesh sieve to obtain the mixed dry paste powder, add 60 g of maltose, mix well, and pour pills with water to obtain pills.

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Abstract

The invention discloses a traditional Chinese medicine composition for treating kidney-yang deficiency type constipation, a preparation and application. The traditional Chinese medicine composition is prepared from, by weight, 15-30 g of herba epimedii, 15-30 g of herba cistanche, 15-30 g of radix angelicae sinensis, 15-30 g of radix morindae officinalis, 10-30 g of fructus cannabis, 10-30 g of semen boitae, 10-30 g of radix achyranthis bidentatae, 10-15 g of rhizoma cimicifugae, 5-30 g of radix et rhizoma rhei, 10-15 g of cortex magnoliae officinalis and 10-30 g of radix rehmanniae preparata. Based on the cause mechanism of constipation caused by kidney-yang deficiency after injury, the treatment principle of purgation and tonification combined application is determined, and the prescription has the effects of purgation without hurting body resistance and tonification without greasiness; the effects of relaxing bowel, tonifying kidney and strengthening bone are achieved; the traditional Chinese medicine composition is precise and appropriate in compatibility, and is definite in curative effect, good in patient compliance and capable of being stopped when constipation dialectically recognized as kidney-yang deficiency in traditional Chinese medicine is treated, and defecation is smooth; clinical experiments show that when the traditional Chinese medicine composition is used for treating the kidney-yang deficiency type constipation, a treatment group is obviously superior to a control group, and the traditional Chinese medicine composition has statistical significance (Plt; the total effective rate of the traditional Chinese medicine syndrome treatment effect reaches 90.9% in a treatment group, the total effective rate of the control group is only 57.57, and it is further proved that the traditional Chinese medicine composition has the remarkable traditional Chinese medicine syndrome treatment effect in the aspect of treating kidney-yang deficiency type constipation.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine compositions and preparations, and in particular relates to a traditional Chinese medicine composition, preparation and application for treating constipation of kidney-yang deficiency type. Background technique [0002] Abdominal distension and constipation after thoracolumbar fractures are the most common, accounting for 70-80% of the total incidence. Constipation increases the suffering of patients and reduces the recovery effect of fractures. After the thoracolumbar fracture, due to the formation of retroperitoneal hematoma, the autonomic nerve is stimulated or even compressed to make it dysfunctional, so that the voluntary control of the anal sphincter and the rectal defecation reflex disappear, and the intestinal peristalsis slows down or even paralyzed. If the feces stay in the intestine for too long, the water will be absorbed, resulting in dry stool and constipation. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/804A61P1/10A61P1/14A61P13/12A61P19/10
CPCY02A50/30
Inventor 易红赤张荆李川林德强董卓谦万青韦佳佳何攀涂文森
Owner 云南省中医医院
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