Medical material surface chitosan/graphene oxide coating and preparation method thereof

A technology of chitosan and graphene, applied in the field of biomedicine, can solve problems such as implant failure and high infection rate, achieve the effects of avoiding local inflammation, strong controllability, and improving antibacterial performance

Pending Publication Date: 2022-04-12
SHANGHAI JIAO TONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, phosphate also provides a convenient place for bacteria to attach and multiply. Due to the high postoperative infection rate of artificial joint replacement and bone implant fixation, phosphate coating on the surface of magnesium alloy will inevitably lead to bacterial proliferation, and even lead to implant failure in severe cases.

Method used

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  • Medical material surface chitosan/graphene oxide coating and preparation method thereof
  • Medical material surface chitosan/graphene oxide coating and preparation method thereof
  • Medical material surface chitosan/graphene oxide coating and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] 1) Prepare a fluorine-substituted hydroxyapatite coating (FHA coating for short, the detailed preparation process can refer to "Electrodeposition of Ca-P coatings on biodegradable Mgalloy: In vitro biomineralization behavior") on the surface of the magnesium alloy substrate by electrodeposition method, and Place in a vacuum drying oven at 60°C for 12 hours;

[0050] 2) Prepare a 5 mg / mL graphene oxide aqueous solution, ultrasonically disperse for 2 hours, and prepare a graphene oxide dispersion;

[0051] 3) Put 0.2 g of chitosan into 10 mL of distilled water, add 0.1 mL of glacial acetic acid, stir with a magnetic stirrer for 24 hours until the chitosan is completely dissolved, and prepare an aqueous solution of chitosan;

[0052] 4) Get 2mL of the dispersed graphene oxide dispersion and slowly add it to the chitosan solution, using a magnetic stirrer and ultrasonic waves alternately until forming a uniformly dispersed chitosan / graphene oxide solution;

[0053] 5) Submer...

Embodiment 2

[0056] 1) Electrodeposition is used to prepare calcium zincite coating (SLZ coating for short, please refer to "Synthesis and degradation behavior of Zn modified coating on Mgalloy" for detailed preparation process) on the surface of magnesium alloy substrate, and put it in a vacuum drying oven for 60 ℃ drying for 12 hours;

[0057] 2) Prepare a 2 mg / mL graphene oxide aqueous solution, ultrasonically disperse for 2 hours, and prepare a graphene oxide dispersion;

[0058] 3) Put 0.2 g of chitosan into 10 mL of distilled water, add 0.1 mL of glacial acetic acid, stir with a magnetic stirrer for 24 hours until the chitosan is completely dissolved, and prepare an aqueous solution of chitosan;

[0059] 4) Get 2mL of the dispersed graphene oxide dispersion and slowly add it to the chitosan solution, using a magnetic stirrer and ultrasonic waves alternately until forming a uniformly dispersed chitosan / graphene oxide solution;

[0060] 5) Submerge the SLZ-coated magnesium alloy sampl...

Embodiment 3

[0063] 1) Prepare calcium hydrogen phosphate dihydrate coating (abbreviated as DCPD coating) on ​​the surface of the magnesium alloy substrate by electrodeposition method, and refer to "Enhanced corrosion resistance and antibacterial property of Zndoped DCPD coating on biodegradable Mg" for detailed preparation process, and put it into Dry in a vacuum oven at 60°C for 12 hours;

[0064] 2) Prepare a 1 mg / mL graphene oxide aqueous solution, ultrasonically disperse for 2 hours, and prepare a graphene oxide dispersion;

[0065] 3) Put 0.1g of chitosan into 10mL of distilled water, add 0.1mL of glacial acetic acid, stir with a magnetic stirrer for 24 hours until the chitosan is completely dissolved, and prepare an aqueous solution of chitosan;

[0066] 4) Take 1 mL of the dispersed graphene oxide solution and slowly add it to the chitosan solution, and use a magnetic stirrer and ultrasonic waves alternately until a uniformly dispersed chitosan / graphene oxide solution is formed;

...

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Abstract

The invention provides a chitosan/graphene oxide coating on the surface of a medical material and a preparation method thereof.The preparation method of the chitosan/graphene oxide coating on the surface of the medical material comprises the following steps that firstly, the medical material with the surface covered with a phosphate coating is prepared, and the medical material is a medical magnesium or magnesium alloy implant; (2) immersing the medical magnesium or magnesium alloy implant obtained in the step (1) into a chitosan/graphene oxide solution, then taking out the medical magnesium or magnesium alloy implant, immersing the medical magnesium or magnesium alloy implant into an alkaline solution, taking out the medical magnesium or magnesium alloy implant, and further washing and drying the medical magnesium or magnesium alloy implant to obtain a chitosan/graphene oxide coating; the coating has good biocompatibility, not only can further enhance the corrosion resistance of the magnesium alloy phosphate coating, but also has excellent antibacterial performance, and well solves the problem of bacterial infection caused by the phosphate coating, and meanwhile, by utilizing the synergistic effect of the phosphate and chitosan/graphene oxide composite coating, the corrosion resistance of the magnesium alloy phosphate coating is improved. And the osteogenesis of the magnesium alloy implant material is further promoted.

Description

technical field [0001] The invention relates to the technical field of biomedicine, and relates to a chitosan / graphene oxide coating on the surface of a medical material and a preparation method thereof, in particular to a chitosan / graphene oxide coating on a phosphate coating on the surface of a medical magnesium alloy. layers and methods of making them. Background technique [0002] After decades of research and development, degradable metal biomedical materials have gradually entered clinical and commercial applications. Among them, magnesium alloy has good biological safety, can be completely degraded in the body fluid environment and absorbed by human tissues, and is a potential application material for orthopedics, general surgery and cardiovascular stents. However, the degradation rate of magnesium alloys in vivo is too fast, which does not match with tissue healing, especially when used as orthopedic implant materials. Cause complications such as inflammation. The...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/34A61L27/04A61L27/30A61L27/32A61L27/54A61L27/58B05D7/14B05D7/24
Inventor 赵常利冯传良
Owner SHANGHAI JIAO TONG UNIV
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