Preparation method of composite drug-loaded fiber based on microfluidics spinning

A fiber and drug-carrying technology, applied in fiber processing, pharmaceutical formulations, fiber chemical characteristics, etc., can solve the problems of physical injury, destruction of drug molecule activity, destruction of drug activity, etc., to inhibit crystallization, improve drug loading, Improves the effect of sustained release

Pending Publication Date: 2022-04-15
SUZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are some limitations in these spinning methods. Dry spinning requires high temperature and requires carrier materials and drugs to be difficult to degrade, which may destroy the activity of drugs; the coagulation bath required by wet spinning is generally toxic liquid, which is harmful to It is harmful to the body and needs to be removed later, which may also destroy the activity of drug molecules; electrospinning generally requires high voltage to spin, and the solvents required to configure the spinning solution are sometimes toxic liquids, which are harmful to the body. harmful

Method used

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  • Preparation method of composite drug-loaded fiber based on microfluidics spinning
  • Preparation method of composite drug-loaded fiber based on microfluidics spinning
  • Preparation method of composite drug-loaded fiber based on microfluidics spinning

Examples

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preparation example Construction

[0038] like figure 1 As shown in FIG. 1 , a flow chart of preparation of a composite drug-loaded fiber based on microflow spinning provided by the present invention is shown. The preparation method based on microflow spinning composite drug-loaded fiber comprises the following steps:

[0039]A1. Take polyvinylpyrrolidone and sodium alginate, add water respectively, stir and heat to obtain polyvinylpyrrolidone solution and sodium alginate solution;

[0040] A2, mixing polyvinylpyrrolidone solution and sodium alginate solution, then adding acetaminophen to form a mixed spinning solution;

[0041] A3. Preparation of continuous composite drug-loaded fibers by means of microfluidic spinning. Embodiment one

Embodiment 1

[0042] Since the microfluidic spinning is carried out at normal temperature and pressure, the spinning liquid is not subjected to other external forces except the thrust of the syringe pump during the entire continuous spinning process, so in order to ensure the normal progress of the spinning process, the solution The concentration is very important for spinning. In order to ensure that the fiber only swells but does not dissolve during the drug release process, it is also important to find the appropriate concentration of sodium alginate and calcium chloride by using ion cross-linking to quickly solidify the fiber. Therefore, this example is to verify the effect of different spinning solution concentrations on the formation of PVP / SA / AAP composite drug-loaded fibers.

[0043] PVP solution and SA solution have a certain viscosity, and as the concentration increases, the solution viscosity will also increase. Since the flow channel of the spinning solution is relatively narro...

Embodiment 2

[0057] This example explores the effect of different AAP mass fractions on the morphology of composite fibers. SEM images of drug-loaded PVP / SA / AAP composite fibers with different AAP mass fractions. Fix the conductive adhesive on the electron microscope stage, then take several PVP / SA / AAP composite fibers prepared above and stick them on the conductive adhesive, spray gold for 90s, and use R-8100 cold-field scanning electron microscope to observe the surface morphology of the fibers. The test condition is a voltage of 3kV and a voltage of 10mA. The composite fiber was brittle broken with liquid nitrogen, and the cross-sectional morphology of the fiber was observed using the same test method and test conditions.

[0058] like Figure 4 shown, where Figure 4 a, 4b, 4c and 4d are shown as SEM images of PVP / SA / AAP composite fibers with AAP mass fractions of 0wt%, 10wt%, 20wt% and 30wt%, respectively.

[0059] from Figure 4 Among them, the surfaces of PVP / SA / AAP composite f...

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Abstract

The invention discloses a preparation method of a composite drug-loaded fiber based on microfluid spinning, which comprises the following steps: A1, taking polyvinylpyrrolidone and sodium alginate, respectively adding water, stirring and heating to obtain a polyvinylpyrrolidone solution and a sodium alginate solution; a2, mixing the polyvinylpyrrolidone solution and the sodium alginate solution, and then adding acetaminophen to form a mixed spinning solution; and A3, taking the mixed spinning solution as a core layer, taking a calcium chloride solution as a sheath flow laminar flow, and preparing the continuous composite drug-loaded fiber in a coaxial microfluid spinning mode. The microfluid spinning technology and the ionic cross-linking curing method are combined to prepare the composite drug-loaded fiber which is neatly arranged and uniform in diameter, the drug loading capacity of the composite drug-loaded fiber is improved, and the drug slow-release effect of the composite drug-loaded fiber is achieved.

Description

technical field [0001] The invention relates to a composite drug-loaded fiber, in particular to a preparation method of the composite drug-loaded fiber based on microflow spinning. Background technique [0002] In the slow and controlled drug release system, the carrier material is one of the important components. The carrier material will affect the release rate of the drug, and different carrier materials may have different drug release kinetics. Generally speaking, a suitable carrier material should have basic characteristics such as good biocompatibility, non-toxic and harmless to humans, easy drug release and stable drug efficacy. [0003] Commonly used carrier materials include biodegradable or non-biodegradable polymer materials, and natural polymer materials. Common carrier materials include polylactic acid, polylactic acid-glycolic acid copolymer, polyvinylpyrrolidone, chitosan, sodium alginate, etc. Among them, polyvinylpyrrolidone is a kind of artificially synt...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): D01F8/10D01F8/18D01F1/10A61K9/00A61K31/167A61K47/32A61K47/36D01D5/34
Inventor 陈宇岳方瑛林红张德锁
Owner SUZHOU UNIV
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