Compound tablet of lamivudine, zidovudine and efavirenz and preparation method thereof

A technology of zidovudine and lamivudine, which is applied in the field of compound tablets of lamivudine, zidovudine and efavirenz and its preparation, can solve the problem of reduced drug efficacy, no compound tablets, effective Composition loss and other issues to achieve the effect of reducing drug resistance, reducing mutual contact, and reducing degradation

Active Publication Date: 2022-04-26
ANHUI BIOCHEM BIO PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Such as CN103908456B tenofovir, lamivudine and efavirenz triple compound pellets and preparation method thereof, it is found that two different main ingredients will degrade when contacted, resulting in the loss of active ingredients and the reduction of drug efficacy
Similarly, this is also a problem that needs to be faced when mixing lamivudine, zidovudine and efavirenz into compound tablets. Currently, there are no compound tablets of the three on the market.

Method used

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  • Compound tablet of lamivudine, zidovudine and efavirenz and preparation method thereof
  • Compound tablet of lamivudine, zidovudine and efavirenz and preparation method thereof
  • Compound tablet of lamivudine, zidovudine and efavirenz and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0029] Experimental Example 1: Grind sodium chloride to below 70 μm, weigh 15g of lamivudine, 1.51g of ground sodium chloride, 0.3g of croscarmellose sodium and feed them into a fluidized bed granulator 10% starch slurry is sprayed in at a constant speed as a binder to fully mix the binder and the weighed material, and lamivudine pellets are prepared in a fluidized bed granulator. Then send it into the coating equipment, and control the temperature of the coating equipment at 45-50° C. to prepare the hydroxypropyl methylcellulose coating liquid, and prepare the lamivudine coated pellets by spraying the coating liquid.

experiment example 2

[0030]Experimental Example 2: Mix sodium chloride and water in a weight ratio of 1:5 and stir until dissolved, then put it into an atomizer, and obtain sodium chloride powder by spray drying. Spray drying is a prior art and will not be described in detail here. Weigh 15g of lamivudine, 1.51g of spray-dried sodium chloride powder, 0.3g of croscarmellose sodium and feed them into a fluidized bed granulator, using 10% starch slurry as a binder Spray at a uniform speed to fully mix the binder and the weighed material, and prepare lamivudine pellets in a fluidized bed granulator. Then send it into the coating equipment, and control the temperature of the coating equipment at 45-50° C. to prepare the hydroxypropyl methylcellulose coating liquid, and prepare the lamivudine coated pellets by spraying the coating liquid.

[0031] Five batches of samples were prepared according to the methods of Experimental Example 1 and Experimental Example 2, respectively, and the content of lamivud...

Embodiment 1

[0036] (1) Preparation of lamivudine coated pellets

[0037]

[0038] The lamivudine, sodium chloride and croscarmellose sodium of prescription quantity are weighed and fed into the fluidized bed granulator, and 10% starch slurry is sprayed in at a uniform speed as a binding agent to make the binding agent The agent and the weighed material are fully mixed, and the lamivudine pellets are prepared in a fluidized bed granulator. Then send it into the coating equipment, and control the temperature of the coating equipment at 45-50° C. to prepare the hydroxypropyl methylcellulose coating liquid, and prepare the lamivudine coated pellets by spraying the coating liquid.

[0039] (2) Preparation of zidovudine coated pellets

[0040]

[0041] Zidovudine, sodium chloride and croscarmellose sodium of prescription quantity are weighed and fed into the fluidized bed granulator, and 10% starch slurry is sprayed in at a uniform speed as a binding agent to make the binding agent The ...

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PUM

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Abstract

The invention provides a compound tablet of lamivudine, zidovudine and efavirenz. The compound tablet is prepared from lamivudine, zidovudine, efavirenz and pharmaceutically acceptable auxiliary materials. Patients take the compound tablets, so that drug resistance of viruses caused by single medication is reduced, and the situation that the patients miss to take a certain medicine is avoided. The preparation method of the compound tablet comprises the following steps: respectively preparing lamivudine coated pellets, zidovudine coated pellets and efavirenz pellets, mixing according to a ratio, and tabletting. The lamivudine, zidovudine and efavirenz compound tablet prepared by the method can avoid mutual contact of the three main drug components, reduce mutual influence and degradation of drugs, improve stability, improve the plasticity and tabletting formability of pellets and improve the dissolution rate.

Description

technical field [0001] The invention relates to the technical field of medicines, in particular to a compound tablet of lamivudine, zidovudine and efavirenz and a preparation method thereof. Background technique [0002] Acquired Immunodeficiency Syndrome (AIDS), or AIDS, is a fatal infectious disease caused by human immunodeficiency virus (HIV) infection. The disease severely damages the human immune system and can cause various symptoms such as bleeding, high fever, swollen lymph nodes, and weakness. The onset of the disease is generally related to factors such as blood infection, sexual contact, and drug use, and some infants and young children are generally infected by mother-to-child transmission. Effective long-term antiretroviral therapy (ART) for HIV-infected patients or AIDS patients by using anti-HIV drugs to inhibit virus replication or invasion can effectively prolong the life of patients and improve their quality of life. The combined use of antiviral drugs is...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/536A61K47/38A61K47/32A61P31/18A61K31/513
CPCA61K31/513A61K31/536A61K9/2081A61K9/5047A61K9/5026A61P31/18A61K2300/00Y02A50/30
Inventor 陈小峰王哲王志邦朱礼根黄德见郭立新刘安友何麓璐刘洋汪亮太
Owner ANHUI BIOCHEM BIO PHARMA
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