Thermal response magnetic hydrogel as well as preparation method and application thereof

A heat-responsive, magnetic water technology, applied in the field of magnetic materials, can solve the problems of embolization therapy for liver cancer, single function of hydrogel materials, and insufficient adhesion performance, and achieve high clinical and market application potential. Excellent performance and stable structure

Active Publication Date: 2022-05-27
HEFEI UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007]The purpose of the present invention is to solve the problem that the existing hydrogel materials cannot take into account both interventional embolization therapy and postoperative liver cancer due to single function, weak mechanical properties and insufficient adhesion performance The problem of anti-relapse treatment, providing a thermally responsive magnetic hydrogel, its preparation method and its application

Method used

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  • Thermal response magnetic hydrogel as well as preparation method and application thereof
  • Thermal response magnetic hydrogel as well as preparation method and application thereof
  • Thermal response magnetic hydrogel as well as preparation method and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0037] The present embodiment carries out the preparation of thermally responsive magnetic hydrogel according to the following steps:

[0038] Step 1: Dissolve 1.5g polyethylene glycol (Mw=4000) and 1g triethylamine in 20mL dichloromethane, pass argon protection, and transfer 1.5g 4-cyano-4-(phenylcarbonylthio) Thio)valeric acid-succinimide ester was dissolved in 10 mL of dichloromethane, added dropwise to the above solution through a dropping funnel, the solution was stirred at room temperature for 24 hours, the resulting product was settled in diethyl ether three times, after vacuum drying Obtain macromolecular chain transfer agent;

[0039] Step 2: Dissolve 0.1 g of the macromolecular chain transfer agent obtained in Step 1 in 5 mL of 1,4-dioxane, put it into a polymerization bottle, and then add 5 g of N-isopropylacrylamide and 2 g of acrylic acid -N-succinimidyl ester, 0.1 g azobisisobutyronitrile, fully dissolved, protected by argon, reacted at 78°C for 24 hours after t...

Embodiment 2

[0055] In this example, a thermally responsive magnetic hydrogel that can be used for multimodal treatment of liver cancer is prepared according to the following steps:

[0056]Step 1: Dissolve 10 g of polyethylene glycol (Mw=4000) and 5 g of triethylamine in 100 mL of dichloromethane, and protect with argon. 40 g of 4-cyano-4-(phenylcarbonylthiothio)valeric acid-succinimide ester was dissolved in 10 mL of dichloromethane, added dropwise to the above solution through a dropping funnel, and the solution was stirred at room temperature In 12 hours, the obtained product was precipitated three times in diethyl ether, and the macromolecular chain transfer agent was obtained after vacuum drying;

[0057] Step 2: Dissolve 0.2g of the macromolecular chain transfer agent obtained in Step 1 in 5mL of 1,4-dioxane, put it into a polymerization bottle, and then add 10g of N-propylacrylamide and 50g of acrylic acid -N-succinimidyl ester, 0.1 benzoyl peroxide, etc., fully dissolved, protect...

Embodiment 3

[0064] In this example, the thermally responsive magnetic hydrogel was prepared as follows:

[0065] Step 1: Dissolve 1.5 g of polyethylene glycol (Mw=4000) and 1 g of triethylamine in 20 mL of dichloromethane, and protect with argon. 1.5 g of 4-cyano-4-(phenylcarbonylthiothio)valeric acid-succinimide ester was dissolved in 10 mL of dichloromethane, added dropwise to the above solution through a dropping funnel, and the solution was allowed to cool at room temperature After stirring for 24 hours, the resulting product was precipitated three times in diethyl ether, and the macromolecular chain transfer agent was obtained after vacuum drying;

[0066] Step 2: Dissolve 0.1 g of the macromolecular chain transfer agent obtained in Step 1 in 5 mL of 1,4-dioxane, put it into a polymerization bottle, and then add 5 g of N-isopropylacrylamide, 2 g of acrylic acid- N-succinimide ester and 0.1 g azobisisobutyronitrile were fully dissolved, protected by argon, and reacted at 40°C for 48 ...

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Abstract

The invention relates to the technical field of magnetic materials, in particular to thermal response magnetic hydrogel as well as a preparation method and application thereof.The thermal response magnetic hydrogel is prepared by adopting a thermo-sensitive polymer and an iron-loaded nanosheet as preparation materials, dissolving the thermo-sensitive polymer in an iron-loaded nanosheet solution, and then adding a crosslinking agent, the novel thermal response magnetic hydrogel which is excellent in magnetocaloric performance and stable in mechanical property and has tissue adhesion can be prepared. The magnetic thermal response hydrogel overcomes the defects that an existing hydrogel embolization agent is single in function, insufficient in mechanical property and prone to fragmentation in blood vessels, intravascular in-situ gelling can be achieved by means of the body temperature, stable intravascular embolization performance is shown, and magnetic thermal response magnetic hydrogel mediated liver cancer interventional embolization combined magnetic thermal therapy is achieved; meanwhile, the magnetic thermal response hydrogel has soft tissue adhesion performance, can be used for liver cancer postoperative local magnetic thermal anti-recurrence treatment, is simple in preparation method, mild in preparation condition and high in biological safety, and can be used as a clinical medical hydrogel material.

Description

technical field [0001] The invention relates to the technical field of magnetic materials, in particular to a thermally responsive magnetic hydrogel, a preparation method and an application thereof. Background technique [0002] Primary liver cancer (HCC) is one of the most common malignant tumors of the digestive system in the world. Surgical resection is the first-line treatment for early-stage liver cancer. The treatment plan for surgical resection of liver cancer faces two important problems: [0003] (1) The onset of primary liver cancer is insidious, with no specific symptoms in the early stage, and most patients are already in the middle and late stages of the disease when they are diagnosed. Transarterial chemoembolization (TACE) is the first-line treatment for advanced liver cancer. TACE with lipiodol mixed chemotherapeutic drug doxorubicin (Iodide@DOX) and doxorubicin-eluting microspheres (DEBDOX) as embolic agents can effectively treat HCC. Iodide@DOX is a liqui...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L24/02A61L24/06A61L24/00A61L24/04A61K41/00A61K9/06A61P35/00C08J3/075C08L53/00C08L25/18C08K3/04
CPCA61L24/02A61L24/06A61L24/001A61L24/0031A61L24/046A61K41/0052A61K9/06A61P35/00C08J3/075A61L2300/416C08J2353/00C08J2425/18C08K3/042C08L71/02C08L25/18C08L53/00
Inventor 陆杨何涛闫旭孙天赐宋永红曹葆强徐运军胡金龙彭伟骆广义李敏陈胜方蔚伟董良宣守虎
Owner HEFEI UNIV OF TECH
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