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Oral liposome composition for improving bone joint health and preparation method thereof

A liposome composition, bone and joint technology, applied in the direction of liposome delivery, drug combination, medical preparations containing active ingredients, etc., to achieve mild operating conditions, improve bone and joint health, improve poor water solubility and bioavailability Effect

Pending Publication Date: 2022-06-10
NINGBO YUFANGTANG BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, dietary supplements commonly used to improve bone and joint health include glucosamine, chondroitin sulfate, frankincense, turmeric, and fish oil, but these dietary supplements have certain limitations : There is controversy over the effect of glucosamine and chondroitin sulfate on improving OA; frankincense can cause intestinal discomfort; turmeric has low bioavailability; fish oil has intolerance and diarrhea problems, etc.
These technologies generally have defects such as difficulty in controlling particle size and distribution, low yield, unsatisfactory encapsulation efficiency and drug loading, large residual organic solvents, and process conditions affecting drug activity.

Method used

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  • Oral liposome composition for improving bone joint health and preparation method thereof
  • Oral liposome composition for improving bone joint health and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0059] Example 1:

[0060] The preparation process of Chinese medicine extract is as follows:

[0061] (a) Atmospheric pressure boiling water extraction: Eucommia leaves, cinnamon, Panax notoginseng leaves, Cyclocarya paliurus leaves, Bamboo leaves, Wintersweet willow leaves, and Pueraria radiata according to the mass ratio of 1~5:1~2:1~5:1~5 : 1~10: 1~5: 1~10, put into the extraction tank for extraction, add purified water, start stirring, heat up and keep the temperature at 98±2°C, extract twice, add 20 times of water for the first time, Extract for 2 hours, add water 10 times for the second time, extract for 1 hour, filter through a 200-mesh sieve, and combine the filtrates;

[0062] (b) Concentration under reduced pressure: Concentrate the extracted filtrate under reduced pressure, the concentration temperature is controlled at 65°C, the vacuum degree is controlled at -0.07~-0.09Mpa, and the relative density is controlled at 1.02~1.05 to obtain the extract;

[0063] (c) ...

Embodiment 2

[0064] Furthermore, due to the use of micro-boiling stirring extraction technology, low-temperature vacuum concentration technology, and spray drying technology, the Chinese medicine extract has fully extracted and retained the active ingredients of Chinese medicine, greatly reducing the dosage.

[0065] Embodiment 2: the preparation of wheat oligopeptide

[0066] The preparation process of wheat oligopeptide is as follows:

[0067] (a) pulping: add an appropriate amount of purified water to wheat protein (gluten powder), stir and beat for 30 minutes, set aside;

[0068] (b) Enzymolysis: heat the above-mentioned wheat protein slurry to 40°C, add compound enzymes such as trypsin and alkaline protease, adjust the pH to 8 and 10 respectively, and the hydrolysis time is 3 hours;

[0069] (c) Enzyme inactivation: after enzymatic hydrolysis, adjust the pH to neutral, heat to boiling, and keep warm for 20 minutes.

[0070] (d) Centrifugation: butterfly or tube centrifuge.

[0071]...

Embodiment 3

[0074] (h) Spray drying: the concentrated solution was sterilized by UHT and then spray-dried. The process parameters were air inlet temperature 165° C., outlet temperature 85° C., and feeding speed 2.0 L / min to obtain wheat oligopeptide powder.

[0075] Embodiment 3: Preparation of cartilage collagen peptide

[0076] (a) Blending: add appropriate amount of purified water to the rabbit cartilage, pulverize, stir for 10-50 minutes, and set aside;

[0077] (b) Enzymatic hydrolysis: heat the above protein slurry to 48-52°C, add trypsin and papain in sequence, adjust the pH to 7.5-8.0 and 5.5-6.5 respectively, and the hydrolysis time is 1-3 hours;

[0078] (c) Enzyme inactivation: after enzymolysis, adjust the pH to neutral, heat to boiling, and keep warm for 10-20 minutes.

[0079] (d) Centrifugation: butterfly or tube centrifuge.

[0080] (e) Membrane filtration: the centrifugate is subjected to membrane filtration, and the filtrate with a molecular weight less than 3000 is co...

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Abstract

The invention relates to an oral liposome composition for improving bone joint health and a preparation method thereof, and the oral liposome composition comprises the following components in parts by mass: 1-10 parts of non-denatured II type collagen, 10-50 parts of cartilage collagen peptide, 1-10 parts of wheat oligopeptide, 5-20 parts of traditional Chinese medicine extract, 1-10 parts of olive fruit extract, 5-10 parts of oyster oligopeptide, 1-10 parts of sodium hyaluronate and 1-10 parts of phytosterol. And 1-10 parts of soybean lecithin. The components are reasonably matched, the palatability is good, preservatives, artificial pigments and synthetic flavors and fragrances are not added, medicine and food homology is achieved, the good effect of improving bone joint health is achieved, the main functional components of medicine and food materials are reserved to the maximum extent through the preparation method, and the health-care food is suitable for being popularized and applied. The bioavailability of the medicine is greatly improved while the dosage is obviously reduced, the patient compliance is good, and the purpose of rapidly improving the osteoarthritis symptom is achieved.

Description

technical field [0001] The invention relates to the field of biotechnology, in particular to an oral liposome composition for improving bone and joint health and a preparation method thereof. Background technique [0002] Osteoarthritis (OA) is a chronic joint disease characterized by degeneration and destruction of articular cartilage and bone metaplasia, also known as osteoarthritis and degenerative osteoarthritis. Osteoarthritis affects most of the joints in the body, such as cervical and lumbar spine, knee joints, hip joints, and interphalangeal joints. Osteoarthritis is a progressive and aggravating disease. The current treatment of osteoarthritis aims to delay the progression of the disease, relieve pain and improve joint function. [0004] At present, dietary supplements commonly used to improve bone and joint health include glucosamine, chondroitin sulfate, frankincense, turmeric, and fish oil, etc., but these dietary supplements have certain limitations: there is...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/39A61K9/127A23L33/105A23L33/11A23L33/12A23L33/125A23L33/18A61P19/02A61K31/728
CPCA61K9/0053A61K9/1277A61K38/39A61K38/012A61K36/32A61K36/46A61K36/54A61K36/258A61K36/52A61K36/899A61K36/185A61K36/488A61K38/011A61K31/728A61K9/0095A61P19/02A23L33/18A23L33/105A23L33/125A23L33/11A23L33/12A23V2002/00A61K2300/00A23V2200/30A23V2250/5422A23V2250/18A23V2250/21A23V2250/51A23V2250/2131A23V2250/21368A23V2250/55
Inventor 王彩霞于善凯袁媛郁新弟晏永球涂宏建张雅玲吴小艳贾福怀
Owner NINGBO YUFANGTANG BIOTECH
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