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Preparation method of BODIPY molecule and optical activity nano-silver-loaded COF material of BODIPY molecule

A molecular, CD-S-3 technology, applied in chemical instruments and methods, wave energy or particle radiation treatment materials, medical preparations of non-active ingredients, etc., can solve the problem of low photothermal conversion rate, poor photothermal stability, etc. problems, achieve great application prospects, improve antibacterial activity, and achieve high light-to-heat conversion efficiency

Pending Publication Date: 2022-06-24
GUANGDONG PHARMA UNIV +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Aiming at the problems existing in the prior art, the present invention provides a design and synthesis of a BODIPY molecule and a sulfur-containing nano-carbon dot (CDs), and self-assembles a COF material based on the two, and adopts an in-situ reduction method An optically active nano-silver-loaded COF material is obtained by loading silver on the COF material. The nano-silver-loaded COF material has the advantages of high photothermal conversion efficiency in the near-infrared region, good photothermal stability, and high antibacterial activity, which overcomes the traditional The materials used in photothermal therapy have problems such as low photothermal conversion rate of light in the near-infrared region and poor photothermal stability.

Method used

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  • Preparation method of BODIPY molecule and optical activity nano-silver-loaded COF material of BODIPY molecule
  • Preparation method of BODIPY molecule and optical activity nano-silver-loaded COF material of BODIPY molecule
  • Preparation method of BODIPY molecule and optical activity nano-silver-loaded COF material of BODIPY molecule

Examples

Experimental program
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Effect test

Embodiment 1

[0060] (1) p-Dimethylaminobenzaldehyde, 2,4-dimethylpyrrole, 2,3-dichloro-5,6-dicyano-p-benzoquinone, triethylamine, boron trifluoride ether, N-iodo The reaction of succinimide and 4-aminophenylboronic acid pinacol ester produces a new type of BODIPY molecule, namely BDP:

[0061] Ⅰ. Take 250mL of anhydrous dichloromethane, add 1.0g of p-dimethylaminobenzaldehyde, protect with argon, then add 2mL of 2,4-dimethylpyrrole and a drop of trifluoroacetic acid, and stir at room temperature under argon React for 24 hours, then add 2.4g of 2,3-dichloro-5,6-dicyano-p-benzoquinone to the reaction system, stir at room temperature for 4 hours, cool to 0°C, add 18mL of triethylamine and 18mL of boron trifluoride in sequence Ethyl ether was stirred at room temperature for 8 hours. The reaction solution was washed with water three times, dried over anhydrous magnesium sulfate, and the solvent was distilled off under reduced pressure. The orange solid, namely BODIPY-0, was obtained by column c...

Embodiment 2

[0071] With COF in embodiment 1 BDP / CD-S-3 -Ag preparation method, the only difference is that 200mM silver nitrate aqueous solution is replaced by 200mM silver ammonia solution to prepare COF BDP / CD-S-3 -Ag-2.

Embodiment 3

[0073] The same as the preparation method of COFBDP / CD-S-3-Ag in Example 1, the only difference is that the 200mM silver nitrate aqueous solution is replaced by 100mM silver ammonia solution and 400mM silver nitrate aqueous solution, respectively, to prepare COF BDP / CD-S-3 -Ag-3 and COF BDP / CD-S-3 -Ag-4.

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Abstract

The invention provides a BODIPY molecule and a preparation method of an optically active nano-silver-loaded COF material of the BODIPY molecule, and relates to the fields of nanometer material science and technology and antibacterial application of the nanometer material science and technology. The invention designs and synthesizes a novel BODIPY molecule and a novel sulfur-containing nano carbon dot (called CD-S for short), and on the basis of the BODIPY molecule and the novel sulfur-containing nano carbon dot (called CD-S for short), a novel optically active nano silver-loaded COF material is synthesized by combining a self-assembly technology and an in-situ reduction technology. The nano-silver-loaded COF material has the advantages of high photo-thermal conversion efficiency, good photo-thermal stability, efficient photodynamic synergistic antibacterial activity and the like, and has huge potential application value in the field of biomedicine.

Description

technical field [0001] The invention relates to nanomaterial science and technology and its antibacterial application field, in particular to a BODIPY molecule and a method for preparing an optically active loaded nano silver COF material. Background technique [0002] Photothermal therapy (Photothermal therapy, PTT) is a treatment method that uses photothermal reagents to convert light energy into heat energy, thereby increasing the local temperature, and relying on high temperature to achieve therapeutic purposes on the lesion. Since the time, position, wavelength and intensity of laser irradiation can be precisely controlled, PTT can exhibit great selectivity and minimal side effects. At the same time, PTT also has high efficiency in the field of antibacterial, broad-spectrum antibacterial and is not easy to produce drug resistance. specialty. Traditional materials used in photothermal therapy have disadvantages such as low photothermal conversion rate of light in the ne...

Claims

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Application Information

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IPC IPC(8): C07F5/02C08G83/00A61K33/38A61K41/00A61K47/69A61P31/04A61P31/10
CPCC07F5/022C08G83/001A61K41/0052A61K33/38A61K47/6949A61P31/04A61P31/10A61K2300/00
Inventor 刘意刘勇万雅婷舒洁张德元
Owner GUANGDONG PHARMA UNIV
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